GRN / Granulin

granulin

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

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Products

Proteins (17)

Type

Over-Expression Lysate (2)

Recombinant (15)

Target

GRN / Granulin (17)

Publications

No (17)

Tag

DDK (Flag) (2)

GST (1)

GST, N-terminus (2)

His (2)

His-S (3)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (11)

Mouse (3)

Rat (2)

Source

293T Cells (1)

E. coli (4)

HEK 293 Cells (7)

Human Cells (2)

Wheat Germ Extract (3)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (7)

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Human GRN / Granulin Protein (Recombinant His-S) (aa21-120) - LS-G14970

Source:

E. coli

Tag:

His-S

Molecular Weight:

16.1 kDa

Price:

10 µg/$259; 50 µg/$331; 100 µg/$482; 200 µg/$602; 1 mg/$1,553; 500 µg/$1,156; 5 mg/$2,481; 2 mg/$1,723

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Human GRN / Granulin Protein (Recombinant DDK (Flag)) (aa1-593) - LS-G3773

Source:

HEK 293 Cells

Tag:

DDK (Flag)

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

~70kDa (SDS-PAGE)

Price:

50 µg/$456; 10 µg/$330

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Human GRN / Granulin Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65777

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

61.7 kDa

Price:

20 µg/$1,107

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Human GRN / Granulin Protein (Recombinant GST, N-terminus) (aa494-593) - LS-G58751

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human GRN / Granulin Protein (Recombinant GST, N-terminus) (aa494-593) - LS-G58752

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human GRN / Granulin Protein (Recombinant His) (Met1-Leu593) - LS-G98595

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

63.2 kDa

Price:

100 µg/$713; 1 mg/$4,085

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Human GRN / Granulin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76263

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

63.54 kDa

Price:

20 µg/$150

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GRN / Granulin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118199

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

63.54 kDa

Price:

100 µg/$494

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Rat GRN / Granulin Protein (Recombinant DDK (Flag)) (aa1-602) - LS-G3864

Source:

HEK 293 Cells

Tag:

DDK (Flag)

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

~65kDa (SDS-PAGE)

Price:

50 µg/$456; 10 µg/$330

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Human GRN / Granulin Protein (Recombinant) (aa1-593) - LS-G3859

Source:

HEK 293 Cells

Tag:

None

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

~72kDa (glycosylated protein by SDS-PAGE)

Price:

50 µg/$526; 10 µg/$344

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Mouse GRN / Granulin Protein (Recombinant) (aa1-589) - LS-G3860

Source:

HEK 293 Cells

Tag:

None

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

~65kDa (SDS-PAGE)

Price:

50 µg/$526; 10 µg/$344

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Human GRN / Granulin Protein (Recombinant GST) (Full Length) - LS-G28716

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

89.9 kDa

Price:

2 µg/$439

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Human GRN / Granulin Protein (Recombinant His-S) (aa361-585) - LS-G14972

Source:

E. coli

Tag:

His-S

Molecular Weight:

30.2 kDa

Price:

10 µg/$255; 50 µg/$323; 100 µg/$450; 200 µg/$562; 1 mg/$1,480; 500 µg/$1,096; 5 mg/$2,395; 2 mg/$1,646

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Mouse GRN / Granulin Protein (Recombinant His-T7) (aa31-269) - LS-G14975

Source:

E. coli

Tag:

His-T7

Molecular Weight:

29.2 kDa

Price:

10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998

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Human GRN / Granulin Protein (Recombinant His-S) (aa234-419) - LS-G14983

Source:

E. coli

Tag:

His-S

Molecular Weight:

25.7 kDa

Price:

10 µg/$243; 50 µg/$291; 100 µg/$339; 200 µg/$402; 1 mg/$1,156; 500 µg/$802; 5 mg/$1,982; 2 mg/$1,298

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Mouse GRN / Granulin Protein (Recombinant His) (Met1-Leu589) - LS-G98789

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

63 kDa

Price:

100 µg/$556

Select

Rat GRN / Granulin Protein (Recombinant) (aa1-602) - LS-G3866

Source:

HEK 293 Cells

Tag:

None

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

~65kDa (SDS-PAGE)

Price:

50 µg/$533; 10 µg/$347

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