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GRIN1 / NMDAR1
glutamate receptor, ionotropic, N-methyl D-aspartate 1
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's disease, epilepsy and ischemic neuronal cell death. Increased membrane surface expression of the NR1 subunit of the receptor has been associated with synaptic plasticity.
| Gene Name: | glutamate receptor, ionotropic, N-methyl D-aspartate 1 |
| Family/Subfamily: | Ion Channel , Glutamate receptor - ionotropic (NMDA receptor) |
| Synonyms: | GRIN1, GluN1, NMDAR1, NR1, MRD8, NMD-R1, NMDA receptor A1, NMDA1, NR1a, GluR zeta 1, N-methyl-D aspartate receptor |
| Target Sequences: | NM_007327 NP_015566.1 Q05586 |
Publications (2)
1
REST-Governed Gene Expression Profiling in a Neuronal Cell Model Reveals Novel Direct and Indirect Processes of Repression and Up-Regulation. Garcia-Manteiga JM, Bonfiglio S, Folladori L, Malosio ML, Lazarevic D, Stupka E, Cittaro D, Meldolesi J. Frontiers in cellular neuroscience. 2015 9:438. (WB; Human)
[Full Text Article]
[PubMed:26617488]
[PMC:PMC4639699]
Related Antibodies: LS-B7013.
2
Direct binding of Toll-like receptor 4 to ionotropic glutamate receptor N-methyl-D-aspartate subunit 1 induced by lipopolysaccharide in microglial cells N9 and EOC 20. Cui J, Yu S, Li Y, Li P, Liu F. International journal of molecular medicine. 2018 March;41:1323-1330. (Human)
[Full Text Article]
[PubMed:29286078]
[PMC:PMC5819937]
Related Antibodies: LS-B13901.
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Antibodies
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GRIN1 / NMDAR1
(138)
Reactivity
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830-910 aa
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840-920 aa
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aa1-564
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(136)
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(6)
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Human
(7)
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(2)
CHO Cells
(1)
E. coli
(1)
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(4)
Wheat Germ Extract
(1)
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Purified
(1)
Neuroscience
GRIN1 / NMDAR1 Rabbit anti-Human Polyclonal (aa864-913) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$440
GRIN1 / NMDAR1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
GRIN1 / NMDAR1 Mouse anti-Rat Monoclonal (aa42-361) (S308-48) Antibody
Mouse, Rat, Human
ICC, IHC, WB
Unconjugated
100 µg/$665
GRIN1 / NMDAR1 Mouse anti-Rat Monoclonal (S308-48) Antibody
Mouse, Rat, Human
ICC, IHC, WB
Unconjugated
100 µg/$442
GRIN1 / NMDAR1 Mouse anti-Rat Monoclonal (aa42-361) (APC) (S308-48) Antibody
Mouse, Rat, Human
ICC, IHC, WB
APC Conjugated
100 µg/$478
GRIN1 / NMDAR1 Mouse anti-Rat Monoclonal (aa42-361) (RPE) (S308-48) Antibody
Mouse, Rat, Human
ICC, IHC, WB
RPE Conjugated
100 µg/$477
GRIN1 / NMDAR1 Rabbit anti-Human Polyclonal (aa856-905) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
GRIN1 / NMDAR1 Mouse anti-Human Monoclonal (aa660-811) (54.1) Antibody
Xenopus, Rat, Human, Monkey
ELISA, ICC, IHC, RIA
Unconjugated
100 µg/$884
GRIN1 / NMDAR1 Mouse anti-Human Monoclonal (Intracellular) (54.1) Antibody
Mouse, Rat, Human, Monkey
ELISA, IHC, IHC-Fr, WB
Unconjugated
100 µg/$786
GRIN1 / NMDAR1 Mouse anti-Human Monoclonal (Biotin) Antibody
Mouse, Rat, Human, Monkey
ELISA, IHC, WB
Biotin Conjugated
100 µl/$1,017
GRIN1 / NMDAR1 Rabbit anti-Human Polyclonal (aa36-53) Antibody
Mouse, Dog, Guinea pig, Bovine, Rat, Hamster, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$575
GRIN1 / NMDAR1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
100 µg/$564
GRIN1 / NMDAR1 Rabbit anti-Rat Monoclonal (aa930-959) Antibody
Mouse, Rat, Hamster, Human, Monkey
IHC, WB
Unconjugated
50 µl/$947
GRIN1 / NMDAR1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Dog, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$299
GRIN1 / NMDAR1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$380
GRIN1 / NMDAR1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
HEK 293 Cells
Myc-DDK (Flag)
97.3 kDa
20 µg/$1,107
Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$730
GRIN1 / NMDAR1 Rabbit anti-Human Polyclonal (pSer896) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
GRIN1 / NMDAR1 Rabbit anti-Human Polyclonal (pSer897) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
GRIN1 / NMDAR1 Rabbit anti-Human Polyclonal (aa862-911) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
GRIN1 / NMDAR1 Mouse anti-Rat Monoclonal (aa834-938) Antibody
Rat
ICC, IP, WB
Unconjugated
200 µg/$907
GRIN1 / NMDAR1 Mouse anti-Rat Monoclonal (PE) Antibody
Rat
ICC, IP, WB
PE Conjugated
100 µl/$1,119
GRIN1 / NMDAR1 Rabbit anti-Rat Polyclonal (N1 Variant) Antibody
Xenopus, Chicken, Mouse, Dog, Rat, Human
IHC, WB
Unconjugated
25 µg/$469
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product results
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