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6737 Mowry Ave
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United States

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GPR49 / LGR5

leucine-rich repeat containing G protein-coupled receptor 5

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.

Gene Name: leucine-rich repeat containing G protein-coupled receptor 5
Family/Subfamily: GPCR , Orphan-A
Synonyms: LGR5, FEX, G-protein coupled receptor 49, G protein-coupled receptor 49, GPR67, GRP49, GPR49, HG38, G-protein coupled receptor 67
Target Sequences: NM_003667 NP_003658.1 O75473

Publications (12)

1
Expression of the adult intestinal stem cell marker Lgr5 in the metastatic cascade of colorectal cancer. Kleist B, Xu L, Li G, Kersten C. International journal of clinical and experimental pathology. 2011 4:327-35. (IHC-P; Human) [Full Text Article] [PubMed:21577318] [PMC:PMC3093057] Related Antibodies: LS-A1236.
2
EP receptor expression in human intestinal epithelium and localization relative to the stem cell zone of the crypts. Olsen Hult LT, Kleiveland CR, Fosnes K, Jacobsen M, Lea T. PloS one. 2011 6:e26816. (ICC, IHC-P; Human) [Full Text Article] [PubMed:22046368] [PMC:PMC3201980] Related Antibodies: LS-A1236, LS-A1232.
3
Prognostic impact of mRNA levels of LGR5 transcript variants in OSCC patients. Rot S, Kaune T, Taubert H, Greither T, Kotrba J, Güttler A, Wichmann H, Bilkenroth U, Wienke A, Al-Nawas B, Bache M, Vordermark D, Wickenhauser C, Bethmann D, Eckert AW, Kappler M. BMC cancer. 2019 February;19:155. [Full Text Article] [PubMed:30770730] [PMC:PMC6377725]
4
CD133 expression predicts post-operative recurrence in patients with colon cancer with peritoneal metastasis. Nagata H, Ishihara S, Kishikawa J, Sonoda H, Murono K, Emoto S, Kaneko M, Sasaki K, Otani K, Nishikawa T, Tanaka T, Kiyomatsu T, Hata K, Kawai K, Nozawa H. International journal of oncology. 2018 March;52:721-732. [Full Text Article] [PubMed:29328371] [PMC:PMC5807045]
5
LGR5 expression in oral epithelial dysplasia and oral squamous cell carcinoma. Andrew J Dalley, Ahmad A Abdul Majeed, Luke P Pitty, Aidan G Major, Camile S Farah. Oral surgery, oral medicine, oral pathology, oral radiology. 2015 April;119:436-40.e1. [Full Text Article] [PubMed:25592865]
6
Lgr5 over-expression is positively related to the tumor progression and HER2 expression in stage pTNM IV colorectal cancer. Feng-Juan Gao, Jie-Yu Chen, Hong-Yan Wu, Jiong Shi, Ming Chen, Xiang-Shan Fan, Qin Huang. International journal of clinical and experimental pathology. 2014 May;7:1572-9. [Full Text Article] [PubMed:24817953] [PMC:PMC4014237]
7
Cell hierarchy and lineage commitment in the bovine mammary gland. Gat Rauner, Itamar Barash. PloS one. 2012 January;7:e30113. [Full Text Article] [PubMed:22253899] [PMC:PMC3258259]
8
LGR5 expression predicts peritoneal recurrence after curative resection of primary colon cancer. Hiroshi Nagata, Soichiro Ishihara, Hiroyuki Abe, Tetsuo Ushiku, Junko Kishikawa, Toshiaki Tanaka, Keisuke Hata, Kazushige Kawai, Masashi Fukayama, Hiroaki Nozawa. British journal of cancer. 2019 May;120:996-1002. [Full Text Article] [PubMed:31000786] [PMC:PMC6734652] Related Antibodies: LS-A1232.
9
Mesenchymal stem cells alleviate TNBS-induced colitis by modulating inflammatory and autoimmune responses. Chen QQ, Yan L, Wang CZ, Wang WH, Shi H, Su BB, Zeng QH, Du HT, Wan J. World journal of gastroenterology : WJG. 2013 Aug;19:4702-17. [Full Text Article] [PubMed:23922467] [PMC:PMC3732842] Related Antibodies: LS-A1236.
10
LGR5 is a marker of poor prognosis in glioblastoma and is required for survival of brain cancer stem-like cells. Nakata S, Campos B, Bageritz J, Bermejo JL, Becker N, Engel F, Acker T, Momma S, Herold-Mende C, Lichter P, Radlwimmer B, Goidts V. Brain pathology (Zurich, Switzerland). 2013 Jan;23:60-72. [Full Text Article] [PubMed:22805276] Related Antibodies: LS-A1235, LS-A1232.
11
Immunostaining of Lgr5, an Intestinal Stem Cell Marker, in Normal and Premalignant Human Gastrointestinal Tissue. Becker L, Huang Q, Mashimo H. TheScientificWorldJournal. 2008 November;8:1168-1176. (IHC-P; Human) [Full Text Article] [PubMed:19030762] [PMC:PMC5848685] Related Antibodies: LS-A1235, LS-A1232.
12
Expression of LGR5, an intestinal stem cell marker, during each stage of colorectal tumorigenesis. Takeda K, Kinoshita I, Shimizu Y, Matsuno Y, Shichinohe T, Dosaka-Akita H. Anticancer research. 2011 Jan;31:263-70. [Full Text Article] [PubMed:21273608] Related Antibodies: LS-A1232.
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GPR49 / LGR5 Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
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PathPlus™ GPR49 / LGR5 Antibody (Cytoplasmic Domain) LS-A1236
Neuroscience
Fast Shipping
(5.0) Rating
(3) Publication(s)
GPR49 / LGR5 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Human
IF, IHC, IHC-P
Unconjugated
50 µg/$440
GPR49 / LGR5 Antibody - Anti-GPR49 / LGR5 antibody IHC of human human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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PathPlus™ GPR49 / LGR5 Antibody (Cytoplasmic Domain) LS-A1235
Neuroscience
Fast Shipping
(5.0) Rating
(2) Publication(s)
GPR49 / LGR5 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
IHC, IHC-P
Unconjugated
50 µg/$440
GPR49 / LGR5 Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
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PathPlus™ GPR49 / LGR5 Antibody (N-Terminus) LS-A1232
Neuroscience
Fast Shipping
(5.0) Rating
(5) Publication(s)
GPR49 / LGR5 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Bat, Human, Monkey
IHC-P
Unconjugated
50 µg/$440
GPR49 / LGR5 Antibody - Formalin-fixed and paraffin-embedded human brain tissue reacted with LGR5/GPR49 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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GPR49 / LGR5 Antibody (aa443-473) LS-C98620
GPR49 / LGR5 Rabbit anti-Human Polyclonal (aa443-473) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
GPR49 / LGR5 Antibody - GPR49 Antibody (LGR5) - IHC of human small intestine using GPR49. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GPR49 / LGR5 Antibody (aa650-700) LS-C143162
GPR49 / LGR5 Rabbit anti-Human Polyclonal (aa650-700) Antibody
Human
IHC, IHC-P, WB
Unconjugated
0.1 ml/$386
GPR49 / LGR5 Antibody - GPR49 Antibody (LGR5) - IHC of human small intestine using GPR49. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GPR49 / LGR5 Antibody (aa650-700, Biotin) LS-C143163
GPR49 / LGR5 Rabbit anti-Human Polyclonal (aa650-700) (Biotin) Antibody
Pig, Human
IHC, IHC-P, WB
Biotin Conjugated
0.1 ml/$416
GPR49 / LGR5 Antibody - GPR49 Antibody (LGR5) - IHC of human small intestine using GPR49. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GPR49 / LGR5 Antibody (aa650-700, DY488) LS-C143165
GPR49 / LGR5 Rabbit anti-Human Polyclonal (aa650-700) (DY488) Antibody
Human
IHC, IHC-P, WB
DY488 Conjugated
0.1 ml/$416
GPR49 / LGR5 Antibody - GPR49 Antibody (LGR5) - IHC of human small intestine using GPR49. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GPR49 / LGR5 Antibody (aa650-700, DY650) LS-C143164
GPR49 / LGR5 Rabbit anti-Human Polyclonal (aa650-700) (DY650) Antibody
Human
IHC, IHC-P, WB
DY650 Conjugated
0.1 ml/$416
GPR49 / LGR5 Antibody - Immunohistochemical staining of paraffin-embedded human small intestine using anti-LGR5 clone UMAB212 mouse monoclonal antibody used at 1ug/mL dilution and detection with Polink2 Broad HRP DAB.requires heat-induced epitope retrieval with TEE pH 9.0 at 95-100C 20 minutes. The image shows two arrows pointing to strong and weak staining of small intestine stem cells.
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GPR49 / LGR5 Antibody (aa22-543, clone UMAB212) LS-C796970
GPR49 / LGR5 Mouse anti-Human Monoclonal (aa22-543) (UMAB212) Antibody
Human
Flo, IF, IHC, PMA, WB
Unconjugated
100 µl/$493
GPR49 / LGR5 Antibody - Immunohistochemical staining of paraffin-embedded human small intestine using anti-LGR5 clone UMAB212 mouse monoclonal antibody used at 1ug/mL dilution and detection with Polink2 Broad HRP DAB.requires heat-induced epitope retrieval with TEE pH 9.0 at 95-100C 20 minutes. The image shows two arrows pointing to strong and weak staining of small intestine stem cells.
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GPR49 / LGR5 Antibody (aa22-543, clone UMAB212, Carrier-free) LS-C796973
GPR49 / LGR5 Mouse anti-Human Monoclonal (aa22-543) (Carrier-free) (UMAB212) Antibody
Human
Flo, IF, IHC, PMA, WB
Unconjugated, Carrier-free
100 µg/$539
GPR49 / LGR5 Antibody - IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-LGR5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).
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GPR49 / LGR5 Antibody (aa250-550, clone OTI2H7) LS-C337374
GPR49 / LGR5 Mouse anti-Human Monoclonal (aa250-550) (OTI2H7) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
GPR49 / LGR5 Antibody - IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-LGR5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).
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GPR49 / LGR5 Antibody (aa250-550, clone OTI2H7, Carrier-free) LS-C786044
GPR49 / LGR5 Mouse anti-Human Monoclonal (aa250-550) (Carrier-free) (OTI2H7) Antibody
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
GPR49 / LGR5 Antibody - Staining HeLa cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
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GPR49 / LGR5 Antibody LS-C804326
GPR49 / LGR5 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
GPR49 / LGR5 Antibody - Figure from citation: Immunohistochemical staining of Lgr5 in normal gastric tissues. The normal gastric tissue, 40×magnified. (A) and 400× magnified. (B). Yellowspots represent the Lgr5 positive cells that are localized only at base of the glands in normal gastric mucosa. The arrows in the pictures show the immunoreactive cells stained in yellow color.
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GPR49 / LGR5 Antibody (aa250-550, clone OTI2A2) LS-C793254
GPR49 / LGR5 Mouse anti-Human Monoclonal (aa250-550) (OTI2A2) Antibody
Mouse, Human
Flo, IF, IHC, IP, WB
Unconjugated
100 µl/$450
GPR49 / LGR5 Antibody - Figure from citation: Immunohistochemical staining of Lgr5 in normal gastric tissues. The normal gastric tissue, 40×magnified. (A) and 400× magnified. (B). Yellowspots represent the Lgr5 positive cells that are localized only at base of the glands in normal gastric mucosa. The arrows in the pictures show the immunoreactive cells stained in yellow color.
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GPR49 / LGR5 Antibody (aa250-550, clone OTI2A2, Carrier-free) LS-C797459
GPR49 / LGR5 Mouse anti-Human Monoclonal (aa250-550) (Carrier-free) (OTI2A2) Antibody
Mouse, Human
Flo, IF, IHC, IP, WB
Unconjugated, Carrier-free
100 µg/$511
GPR49 / LGR5 Antibody - Immunohistochemical staining of paraffin-embedded human colon cancer using mouse anti-LGR5 clone UMAB210 at 1:400 with GBI Polink2 Broad HRP DAB detection kit. (D22-110); pretreatment of tissue prior to stain with heat-induced epitope retrieval buffer from GBI Labs TEE pH 9.0. (B21-100) using pressure chamber for 3 minutes at 110C is required for optimal staining. Shown here strong cytoplamic tumor cells.
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GPR49 / LGR5 Antibody (aa22-543, clone UMAB210) LS-C796968
GPR49 / LGR5 Mouse anti-Human Monoclonal (aa22-543) (UMAB210) Antibody
Mouse, Human
Flo, IF, IHC, PMA, WB
Unconjugated
100 µl/$493
GPR49 / LGR5 Antibody - Immunohistochemical staining of paraffin-embedded human colon cancer using mouse anti-LGR5 clone UMAB210 at 1:400 with GBI Polink2 Broad HRP DAB detection kit. (D22-110); pretreatment of tissue prior to stain with heat-induced epitope retrieval buffer from GBI Labs TEE pH 9.0. (B21-100) using pressure chamber for 3 minutes at 110C is required for optimal staining. Shown here strong cytoplamic tumor cells.
Select
GPR49 / LGR5 Antibody (aa22-543, clone UMAB210, Carrier-free) LS-C796971
GPR49 / LGR5 Mouse anti-Human Monoclonal (aa22-543) (Carrier-free) (UMAB210) Antibody
Mouse, Human
Flo, IF, IHC, PMA, WB
Unconjugated, Carrier-free
100 µg/$539
GPR49 / LGR5 Antibody - Immunohistochemical staining of paraffin-embedded human colon cancer using mouse anti-LGR5 clone UMAB211 at 1:400 with GBI Polink2 Broad HRP DAB detection kit. (D22-110); pretreatment of tissue prior to stain with heat-induced epitope retrieval buffer from GBI Labs TEE pH 9.0. (B21-100) using pressure chamber for 3 minutes at 110C is required for optimal staining. Shown here strong cytoplamic tumor cells.
Select
GPR49 / LGR5 Antibody (aa22-543, clone UMAB211) LS-C796972
GPR49 / LGR5 Mouse anti-Human Monoclonal (aa22-543) (UMAB211) Antibody
Human
Flo, IF, IHC, PMA, WB
Unconjugated
100 µl/$493
GPR49 / LGR5 Antibody - Immunohistochemical staining of paraffin-embedded human colon cancer using mouse anti-LGR5 clone UMAB211 at 1:400 with GBI Polink2 Broad HRP DAB detection kit. (D22-110); pretreatment of tissue prior to stain with heat-induced epitope retrieval buffer from GBI Labs TEE pH 9.0. (B21-100) using pressure chamber for 3 minutes at 110C is required for optimal staining. Shown here strong cytoplamic tumor cells.
Select
GPR49 / LGR5 Antibody (aa22-543, clone UMAB211, Carrier-free) LS-C796969
GPR49 / LGR5 Mouse anti-Human Monoclonal (aa22-543) (Carrier-free) (UMAB211) Antibody
Human
Flo, IF, IHC, PMA, WB
Unconjugated, Carrier-free
100 µg/$539
GPR49 / LGR5 Antibody - Anti-LGR5 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LGR5.
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GPR49 / LGR5 Antibody (aa250-550, clone OTI1C8) LS-C337372
GPR49 / LGR5 Mouse anti-Human Monoclonal (aa250-550) (OTI1C8) Antibody
Human
Flo, IF, WB
Unconjugated
100 µl/$434
GPR49 / LGR5 Antibody - Anti-LGR5 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LGR5.
Select
GPR49 / LGR5 Antibody (aa250-550, clone OTI1C8, Carrier-free) LS-C786042
GPR49 / LGR5 Mouse anti-Human Monoclonal (aa250-550) (Carrier-free) (OTI1C8) Antibody
Human
Flo, IF, WB
Unconjugated, Carrier-free
100 µg/$511
GPR49 / LGR5 Antibody - Anti-LGR5 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LGR5.
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GPR49 / LGR5 Antibody (aa250-550, clone OTI11B5) LS-C337373
GPR49 / LGR5 Mouse anti-Human Monoclonal (aa250-550) (OTI11B5) Antibody
Human
Flo, IF, WB
Unconjugated
100 µl/$434
GPR49 / LGR5 Antibody - Anti-LGR5 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LGR5.
Select
GPR49 / LGR5 Antibody (aa250-550, clone OTI11B5, Carrier-free) LS-C786043
GPR49 / LGR5 Mouse anti-Human Monoclonal (aa250-550) (Carrier-free) (OTI11B5) Antibody
Human
Flo, IF, WB
Unconjugated, Carrier-free
100 µg/$511
GPR49 / LGR5 Antibody - Anti-LGR5 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LGR5.
Select
GPR49 / LGR5 Antibody (aa250-550, clone OTI7H7) LS-C337377
GPR49 / LGR5 Mouse anti-Human Monoclonal (aa250-550) (OTI7H7) Antibody
Human
Flo, IF, WB
Unconjugated
100 µl/$434
GPR49 / LGR5 Antibody - Anti-LGR5 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LGR5.
Select
GPR49 / LGR5 Antibody (aa250-550, clone OTI7H7, Carrier-free) LS-C786047
GPR49 / LGR5 Mouse anti-Human Monoclonal (aa250-550) (Carrier-free) (OTI7H7) Antibody
Human
Flo, IF, WB
Unconjugated, Carrier-free
100 µg/$511
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