GLP1R / GLP-1 Receptor

glucagon-like peptide 1 receptor

GLP1R, a Glucagon Receptor, has been suggested to affect the feelings of satiety or hunger, sensation of glucose levels, control of glucagon sensitivity of islets, and non insulin-dependent diabetes mellitus. Glucagon-like peptide 1 is an incretin hormone produced by enteroendocrine L-cells in the intestinal mucosa. The hormone is released in response to food intake and plays an important role in maintaining blood glucose homeostasis. Stimulation of the GLP-1R by endogenous hormone induces multiple complementary mechanisms, which together result in a lowering of circulating blood glucose levels. These mechanisms include receptor-mediated enhancement of glucose-induced insulin secretion from pancreatic -cells, inhibition of gastric emptying with a delay in the gastrointestinal resorption of nutrients, inhibition of glucagon secretion, and inhibition of food intake. Desensitization of GLP1R on pancreatic beta-cells is one of the causes of non insulin-dependent diabetes mellitus (NIDDM). GLP1R knockout mice are viable, develop normally, but exhibit increased levels of blood glucose following oral glucose challenge in association with diminished levels of circulating insulin. Recently it has been shown that overexpression of glucagon-like peptide-1 receptor improves learning in rats (During et al. 2003).

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Products

Proteins (14)

Type

Over-Expression Lysate (2)

Recombinant (12)

Target

GLP1R / GLP-1 Receptor (14)

Publications

No (14)

Tag

10His, N-terminus (3)

6His, N-terminus (4)

6His-SUMO, N-terminus (1)

Fc, C-terminus (2)

His (2)

Myc-DDK (Flag) (2)

Species

Human (8)

Mouse (2)

Rat (3)

Source

293T Cells (1)

Baculovirus (2)

E. coli (5)

HEK 293 Cells (1)

Mammalian Cells (3)

Yeast (2)

Purification

Purified (8)

Low Endotoxin Level

Low endotoxin level (2)

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Human GLP1R / GLP-1 Receptor Protein (Recombinant His) (aa24-145) - LS-G22934

Source:

Yeast

Tag:

His

Molecular Weight:

16.3 kD

Price:

1 mg/$1,607; 100 µg/$469; 20 µg/$349

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Human GLP1R / GLP-1 Receptor Protein (Recombinant His) (aa24-145) - LS-G20773

Source:

E. coli

Tag:

His

Molecular Weight:

18.4 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Mouse GLP1R / GLP-1 Receptor Protein (Recombinant 6His, N-terminus) (aa25-145) - LS-G25307

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

21.5 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Human GLP1R / GLP-1 Receptor Protein (Recombinant 10His, N-terminus) (Full Length) - LS-G136907

Source:

E. coli

Tag:

10His, N-terminus

Molecular Weight:

53.6 kDa

Price:

100 µg/$1,293; 20 µg/$854

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Human GLP1R / GLP-1 Receptor Protein (Recombinant Fc, C-terminus) - LS-G137866

Source:

Mammalian Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 0.1 ng/mL (Less than 1 EU/µg) (determined by LAL method).

Price:

10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157

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GLP1R / GLP-1 Receptor Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99636

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.8 kDa

Price:

100 µg/$494

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Human GLP1R / GLP-1 Receptor Protein (Recombinant Fc, C-terminus) (Arg24-Tyr145) - LS-G139818

Source:

Mammalian Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

41.2 kDa

Price:

10 µg/$288; 50 µg/$436

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Rat GLP1R / GLP-1 Receptor Protein (Recombinant 6His, N-terminus) (aa22-135) - LS-G57176

Source:

Yeast

Tag:

6His, N-terminus

Price:

100 µg/$679; 20 µg/$429; 1 mg/$1,973

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Rat GLP1R / GLP-1 Receptor Protein (Recombinant 6His, N-terminus) (aa22-135) - LS-G56288

Source:

E. coli

Tag:

6His, N-terminus

Price:

1 mg/$1,679; 100 µg/$598; 20 µg/$405

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Mouse GLP1R / GLP-1 Receptor Protein (Recombinant 6His-SUMO, N-terminus) (aa22-145) - LS-G56289

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human GLP1R / GLP-1 Receptor Protein (Recombinant 10His, N-terminus) (aa24-145) - LS-G55955

Source:

Baculovirus

Tag:

10His, N-terminus

Price:

100 µg/$1,067; 20 µg/$447; 1 mg/$1,988

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Rat GLP1R / GLP-1 Receptor Protein (Recombinant 10His, N-terminus) (aa22-135) - LS-G55956

Source:

Baculovirus

Tag:

10His, N-terminus

Price:

100 µg/$1,067; 20 µg/$447; 1 mg/$1,988

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Human GLP1R / GLP-1 Receptor Protein (Recombinant 6His, N-terminus) (aa24-145) - LS-G57038

Source:

Mammalian Cells

Tag:

6His, N-terminus

Price:

100 µg/$1,116; 20 µg/$461

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Human GLP1R / GLP-1 Receptor Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G82039

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.8 kDa

Price:

20 µg/$150

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