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Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells.
Gene Name: | growth differentiation factor 9 |
Family/Subfamily: | TGF beta , not assigned-TGF beta |
Synonyms: | GDF9, GDF-9 |
Target Sequences: | NM_005260 NP_005251.1 O60383 |
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