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FZD5 / Frizzled 5
frizzled class receptor 5
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta-catenin pathway.
| Gene Name: | frizzled class receptor 5 |
| Family/Subfamily: | GPCR , Frizzled |
| Synonyms: | FZD5, C2orf31, DKFZP434E2135, Frizzled family receptor 5, Fz5, Fzd-5, FzE5, Frizzled 5, Frizzled-5, Wnt receptor, Fz-5, HFZ5 |
| Target Sequences: | NM_003468 NP_003459.2 Q13467 |
Publications (1)
1
RAL GTPases Drive Intestinal Stem Cell Function and Regeneration through Internalization of WNT Signalosomes. Johansson J, Naszai M, Hodder MC, Pickering KA, Miller BW, Ridgway RA, Yu Y, Peschard P, Brachmann S, Campbell AD, Cordero JB, Sansom OJ. Cell stem cell. 2019 April;24:592-607. [Full Text Article]
[PubMed:30853556]
[PMC:PMC6459002]
Related Antibodies: LS-A4273.
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Cancer
FZD5 / Frizzled 5 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Hamster, Human
IHC, IHC-P
Unconjugated
50 µg/$460
Fast Shipping
FZD5 / Frizzled 5 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Rabbit, Dog, Bovine, Pig, Human, Monkey
ELISA, IHC, IHC-P
Unconjugated
50 µg/$440
FZD5 / Frizzled 5 Mouse anti-Human Monoclonal (2D12) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µl/$459
FZD5 / Frizzled 5 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
FZD5 / Frizzled 5 Rabbit anti-Human Polyclonal (440-520 aa, C-terminal) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
Cancer
Fast Shipping
FZD5 / Frizzled 5 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
FZD5 / Frizzled 5 Rabbit anti-Human Polyclonal (aa461-510) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
FZD5 / Frizzled 5 Rabbit anti-Human Polyclonal (aa467-516) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
FZD5 / Frizzled 5 Rabbit anti-Human Polyclonal (aa467-516) (HRP) Antibody
Mouse, Bovine, Rat, Human
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
FZD5 / Frizzled 5 Rabbit anti-Human Polyclonal (aa467-516) (Biotin) Antibody
Mouse, Bovine, Rat, Human
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
FZD5 / Frizzled 5 Rabbit anti-Human Polyclonal (aa467-516) (FITC) Antibody
Mouse, Bovine, Rat, Human
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
FZD5 / Frizzled 5 Rabbit anti-Human Polyclonal (aa31-80) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
100 µl/$515
FZD5 / Frizzled 5 Goat anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$951
FZD5 / Frizzled 5 Rabbit anti-Human Polyclonal (aa564-585) Antibody
Human
WB
Unconjugated
200 µg/$786
FZD5 / Frizzled 5 Rabbit anti-Human Polyclonal (Tyr500) Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
50 µl/$321; 100 µl/$403
FZD5 / Frizzled 5 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC
Unconjugated
100 µg/$357
FZD5 / Frizzled 5 Mouse anti-Human Monoclonal (6A3) Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$423
FZD5 / Frizzled 5 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100 µg/$357
FZD5 / Frizzled 5 Mouse anti-Human Monoclonal (Amino Acid: 151-217) (2D12) Antibody
Human
Flo, WB
Unconjugated
100 µg/$503
FZD5 / Frizzled 5 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$299
FZD5 / Frizzled 5 Rabbit anti-Human Polyclonal (aa472-500) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
FZD5 / Frizzled 5 Rabbit anti-Human Polyclonal (aa472-500) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
FZD5 / Frizzled 5 Rabbit anti-Human Polyclonal (aa472-500) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
FZD5 / Frizzled 5 Rabbit anti-Human Polyclonal (aa472-500) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
FZD5 / Frizzled 5 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$351
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