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FZD4 / Frizzled 4
frizzled class receptor 4
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
| Gene Name: | frizzled class receptor 4 |
| Family/Subfamily: | GPCR , Frizzled |
| Synonyms: | FZD4, CD344, CD344 antigen, EVR1, Frizzled family receptor 4, Frizzled-4, Fz-4, Fz4, HFz4, Exudative vitreoretinopathy 1, FEVR, FZD4S, FzE4, Frizzled 4, Frizzled homolog 4, WNT receptor frizzled-4 |
| Target Sequences: | NM_012193 NP_036325.2 Q9ULV1 |
Publications (2)
1
Mutual Zonated Interactions of Wnt and Hh Signaling Are Orchestrating the Metabolism of the Adult Liver in Mice and Human. Erik Kolbe, Susanne Aleithe, Christiane Rennert, Luise Spormann, Fritzi Ott, David Meierhofer, Robert Gajowski, Claus Stöpel, Stefan Hoehme, Michael Kücken, Lutz Brusch, Michael Seifert, Witigo von Schoenfels, Clemens Schafmayer, Mario Brosch, Ute Hofmann, Georg Damm, Daniel Seehofer, Jochen Hampe, Rolf Gebhardt, Madlen Matz-Soja. Cell reports. 2019 December;29:4553-4567.e7. [Full Text Article]
[PubMed:31875560]
Related Antibodies: LS-B5723.
2
Tumor suppressor microRNA-493 decreases cell motility and migration ability in human bladder cancer cells by downregulating RhoC and FZD4. Ueno K, Hirata H, Majid S, Yamamura S, Shahryari V, Tabatabai ZL, Hinoda Y, Dahiya R. Molecular cancer therapeutics. 2012 Jan;11:244-53. [Full Text Article]
[PubMed:22057916]
[PMC:PMC3940358]
Related Antibodies: LS-C6904.
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FZD4 / Frizzled 4 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
FZD4 / Frizzled 4 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
FZD4 / Frizzled 4 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
FZD4 / Frizzled 4 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
Cancer
Fast Shipping
FZD4 / Frizzled 4 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Dog, Bovine, Rat, Hamster, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
Cancer
Fast Shipping
FZD4 / Frizzled 4 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Chicken, Bovine, Rat, Hamster, Pig, Horse, Bat, Rabbit, Mouse, Dog, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
FZD4 / Frizzled 4 Rat anti-Mouse Monoclonal (Extracellular Domain) Antibody
Mouse, Human
Flo, ICC, WB
Unconjugated
50 µg/$649; 100 µg/$973
FZD4 / Frizzled 4 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
WB
Unconjugated
30 µl/$255; 50 µl/$271; 100 µl/$299; 200 µl/$351
FZD4 / Frizzled 4 Rat anti-Mouse Monoclonal (Biotin) Antibody
Mouse, Human
Flo, IHC, WB
Biotin Conjugated
100 µg/$832
FZD4 / Frizzled 4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC-P, WB
Unconjugated
100 µg/$575
FZD4 / Frizzled 4 Mouse anti-Human Monoclonal (3G7) Antibody
Human
ELISA, WB
Unconjugated
50 µg/$423
FZD4 / Frizzled 4 Goat anti-Human Polyclonal (aa39-51) Antibody
Xenopus, Bat, Horse, Rabbit, Dog, Bovine, Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µg/$503
FZD4 / Frizzled 4 Rabbit anti-Human Polyclonal (aa280-329) Antibody
Human
WB
Unconjugated
100 µl/$424
FZD4 / Frizzled 4 Goat anti-Mouse Polyclonal Antibody
Mouse
ELISA, ICC, IHC, WB
Unconjugated
100 µg/$930
FZD4 / Frizzled 4 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC-P, WB
Unconjugated
50 µg/$460
FZD4 / Frizzled 4 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC
Unconjugated
50 µg/$294; 100 µg/$360
FZD4 / Frizzled 4 Mouse anti-Human Monoclonal (2F3A7) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µg/$459
FZD4 / Frizzled 4 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
FZD4 / Frizzled 4 Rabbit anti-Human Polyclonal (100-180 aa, Internal) Antibody
Mouse, Rat, Human
ELISA, IF
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
FZD4 / Frizzled 4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF
Unconjugated
100 µg/$357
FZD4 / Frizzled 4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF
Unconjugated
100 µg/$357
FZD4 / Frizzled 4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
FZD4 / Frizzled 4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
FZD4 / Frizzled 4 Rabbit anti-Human Polyclonal (aa131-180) Antibody
Mouse, Rat, Human
IF, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
FZD4 / Frizzled 4 Rabbit anti-Human Polyclonal (aa131-180) Antibody
Mouse, Rat, Human
IF, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
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