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FZD2 / Frizzled 2
frizzled class receptor 2
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
| Gene Name: | frizzled class receptor 2 |
| Family/Subfamily: | GPCR , Frizzled |
| Synonyms: | FZD2, Dfrizzled2, Fz2, Frizzled family receptor 2, Frizzled-2, HFz2, Frizzled homolog 2, Fz-2, FzE2, Mfz10, Rfz2, Frizzled 2 |
| Target Sequences: | NM_001466 NP_001457.1 Q14332 |
Publications (1)
1
A mutation in FRIZZLED2 impairs Wnt signaling and causes autosomal dominant omodysplasia. Saal HM, Prows CA, Guerreiro I, Donlin M, Knudson L, Sund KL, Chang CF, Brugmann SA, Stottmann RW. Human molecular genetics. 2015 24:3399-409. (WB; Human)
[Full Text Article]
[PubMed:25759469]
[PMC:PMC4834928]
Related Antibodies: LS-C166295.
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FZD2 / Frizzled 2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
Cancer
Fast Shipping
FZD2 / Frizzled 2 Rabbit anti-Human Polyclonal (Extracellular Domain) Antibody
Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human
IHC, IHC-P
Unconjugated
50 µg/$440
FZD2 / Frizzled 2 Goat anti-Human Polyclonal (aa267-279) Antibody
Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
FZD2 / Frizzled 2 Rabbit anti-Human Polyclonal (aa534-563) Antibody
Human
WB
Unconjugated
400 µl/$393
FZD2 / Frizzled 2 Rat anti-Mouse Monoclonal (Extracellular Domain) Antibody
Mouse
ELISA, WB
Unconjugated
500 µg/$1,093
FZD2 / Frizzled 2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
IP, WB
Unconjugated
100 µg/$737
FZD2 / Frizzled 2 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
IP, WB
HRP Conjugated
100 µl/$982
FZD2 / Frizzled 2 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
IP, WB
Biotin Conjugated
100 µl/$982
FZD2 / Frizzled 2 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
IP, WB
FITC Conjugated
100 µl/$982
FZD2 / Frizzled 2 Rabbit anti-Human Polyclonal (PE) Antibody
Human
IP, WB
PE Conjugated
100 µl/$982
FZD2 / Frizzled 2 Rabbit anti-Human Polyclonal (180-260 aa, Internal) Antibody
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
FZD2 / Frizzled 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100 µg/$357
FZD2 / Frizzled 2 Rabbit anti-Human Polyclonal (aa201-250) Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
FZD2 / Frizzled 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
FZD2 / Frizzled 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
50 µg/$305; 100 µg/$357
FZD2 / Frizzled 2 Rabbit anti-Human Polyclonal (Glu240) Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
50 µl/$321; 100 µl/$403
FZD2 / Frizzled 2 Mouse anti-Human Monoclonal (2C8) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
FZD2 / Frizzled 2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$341
FZD2 / Frizzled 2 Rabbit anti-Human Polyclonal (aa534-563) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
FZD2 / Frizzled 2 Rabbit anti-Human Polyclonal (aa534-563) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
FZD2 / Frizzled 2 Rabbit anti-Human Polyclonal (aa534-563) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
FZD2 / Frizzled 2 Rabbit anti-Human Polyclonal (aa534-563) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
FZD2 / Frizzled 2 Rabbit anti-Human Polyclonal (aa534-563) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
FZD2 / Frizzled 2 Rabbit anti-Human Polyclonal (aa534-563) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
FZD2 / Frizzled 2 Rabbit anti-Human Polyclonal (aa191-240) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
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