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FTL / Ferritin Light Chain is the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes.
Gene Name: | ferritin, light polypeptide |
Synonyms: | FTL, Ferritin L subunit, Ferritin L-chain, Ferritin, light polypeptide, Ferritin light chain, NBIA3 |
Target Sequences: | NM_000146 NP_000137.2 P02792 |
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