Human FTL / Ferritin Light Chain

Rabbit

Human (tested or 100% immunogen sequence identity)

IgG Recombinant Monoclonal

FTL/2338R

Unconjugated

Protein A/G purified

Unmodified. Also available Azide-free, Carrier-free.

Recombinant human FTL protein fragment (around aa 38-165). Antigen Molecular Weight: 19-25 kDa

aa 38-165

Mammalian ferritins consist of 24 subunits made up of 2 types of polypeptide chains, ferritin heavy chain and ferritin light chain. Ferritin heavy chains catalyze the first step in iron storage, the oxidation of Fe (II), whereas ferritin light chains promote the nucleation of ferrihydrite, enabling storage of Fe (III). Light chain ferritin is involved in cataracts by at least two mechanisms, hereditary hyperferritinemia cataract syndrome, in which light chain ferritin is overexpressed, and oxidative stress, an important factor in the development of ageing-related cataracts.

• IHC - Paraffin (1:100)
• Western blot (0.5 - 2 µg/ml)

Western Blotting (0.5-2 ug/ml) - Immunohistology (Formalin-fixed - 0.5-1.0 ug/ml for 30 min at RT - Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.) Optimal dilution for a specific application should be determined.

10 mM PBS, 0.05% BSA, 0.05% Sodium Azide

Store at 2°C to 8°C for up to 2 years.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P02792 NCBI: NM_000146 NP_000137.2