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FST / Follistatin

follistatin

Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin.

Gene Name: follistatin
Synonyms: FST, Activin-binding protein, Follistatin isoform FST317, Follistatin, Fs
Target Sequences: NM_006350 NP_006341.1 P19883

Publications (4)

1
Follistatin is a novel therapeutic target and biomarker in FLT3/ITD acute myeloid leukemia. Bai-Liang He , Ning Yang , Cheuk Him Man, Nelson Ka-Lam Ng, Chae-Yin Cher, Ho-Ching Leung, Leo Lai-Hok Kan, Bowie Yik-Ling Cheng, Stephen Sze-Yuen Lam, Michelle Lu-Lu Wang, Chun-Xiao Zhang, Hin Kwok, Grace Cheng, Rakesh Sharma, Alvin Chun-Hang Ma, Chi Wai Eric So, Yok-Lam Kwong, Anskar Yu-Hung Leung. EMBO molecular medicine. 2020 Apr;12:e10895. [Full Text Article] [PubMed:32134197] [PMC:PMC7136967]
2
Follistatin-induced muscle hypertrophy in aged mice improves neuromuscular junction innervation and function. Chitra C Iyer, Deepti Chugh, Prameela J Bobbili, Anton J Blatnik Iii, Alexander E Crum, Allen F Yi, Brian K Kaspar, Kathrin C Meyer, Arthur H M Burghes, W David Arnold. Neurobiology of aging. 2021 August;104:32-41. [Full Text Article] [PubMed:33964607] [PMC:PMC8225567]
3
Detection of black market follistatin 344. Christian Reichel, Günter Gmeiner, Mario Thevis. Drug testing and analysis. 2020 October;12:1522-1533. [Full Text Article] [PubMed:33460286]
4
Detection of black market follistatin 344. Christian Reichel, Günter Gmeiner, Mario Thevis. Drug testing and analysis. 2019 November;11:1675-1697. [Full Text Article] [PubMed:31758732]
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Products
Proteins (23)
Over-Expression Lysate (4)
Recombinant (19)
FST / Follistatin (23)
Bind (1)
ELISA (1)
Func (1)
SDS-PAGE (5)
No (20)
Yes (3)
Fc (2)
GST (1)
His (3)
His,C-terminus (5)
His-T7 (1)
Human IgG Fc, C-terminus (2)
Myc-DDK (Flag) (6)
Human (17)
Mouse (4)
293T Cells (2)
CHO Cells (2)
E. coli (4)
HEK 293 Cells (11)
Human Cells (1)
Mammalian Cells (1)
Sf9 Cells (1)
Wheat Germ Extract (1)
Purified (9)
Low endotoxin level (14)
Biologically active (6)
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
31.5 kDa
5 µg/$268; 20 µg/$349
Select
HEK 293 Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
61.7 kDa
50 µg/$503
FST / Follistatin Protein
Select
Sf9 Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
50 µg/$361; 250 µg/$739; 10 µg/$261
FST / Follistatin Protein
Select
E. coli
His
20 µg/$361; 100 µg/$739; 4 µg/$261
FST / Follistatin Protein - 12.5% SDS-PAGE of human FST stained with Coomassie Blue
Select
Wheat Germ Extract
GST
63.58 kDa
10 µg/$479; 25 µg/$670
FST / Follistatin Protein
Select
HEK 293 Cells
His,C-terminus
SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant mouse FST comprises 326 amino acids and has a predicted molecular mass of 36.1 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmFST is approximately 70-80 kDa due to glycosylation.
50 µg/$379; 500 µg/$1,538
FST / Follistatin Protein - Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation. The ED50 for this effect is typically 40-200 ng/mL in the presence of 10 ng/mL rhActivin A.
Select
CHO Cells
Human IgG Fc, C-terminus
SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant mouse FST comprises 528 amino acids and has a predicted molecular mass of 58.4 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of the protein is approximately 66 kDa due to glycosylation.
50 µg/$441
FST / Follistatin Protein
Select
HEK 293 Cells
His,C-terminus
SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human FST consists 311 amino acids and predicts a molecular mass of 34.4 kDa.
100 µg/$480; 1 mg/$2,333
FST / Follistatin Protein - Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation. The ED50 for this effect is typically 0.5-3 µg/mL in the presence of 10 ng/ml Recombinant Human ctivin A.
Select
HEK 293 Cells
Human IgG Fc, C-terminus
Bind ELISA Func SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The secreted recombinant human FST/Fc is a disulfide-linked homodimer. The reduced monomer consists of 556 amino acids and has a predicted molecular mass of 61.7 kDa. As a result of glycosylation, rh FST/Fc monomer migrates as an approximately 70 kDa band in SDS-PAGE under reducing conditions.
50 µg/$403; 500 µg/$1,538
FST / Follistatin Protein
Select
HEK 293 Cells
His,C-terminus
SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The secreted recombinant human FST (FS288) consists of 299 amino acids and has a predicted molecular mass of 33 kDa. As a result of glycosylation, rhFST (FS288) migrates as an approximately 45 kDa band in SDS-PAGE under reducing conditions.
50 µg/$379; 500 µg/$1,538
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
36.1 kDa
50 µg/$721
FST / Follistatin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
34.8 kDa
20 µg/$150
Select
293T Cells
Myc-DDK (Flag)
38.01 kDa
20 µg/$150
FST / Follistatin Protein - Purified recombinant protein FST was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
31.5 kDa
20 µg/$1,107
FST / Follistatin Protein - Purified recombinant protein FST was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
34.7 kDa
20 µg/$1,107
FST / Follistatin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
38.01 kDa
100 µg/$494
FST / Follistatin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
34.8 kDa
100 µg/$494
Select
Mammalian Cells
None
Less than 1.0 EU/µg protein (determined by LAL method).
32.4 kDa
10 µg/$277; 50 µg/$389
Select
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
34.4 kDa
100 µg/$982
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
~31 kDa
10 µg/$432; 1 mg/$8,695
Select
CHO Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
58.4 kDa
50 µg/$721
Select
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
33 kDa
50 µg/$648; 500 µg/$2,960
FST / Follistatin Protein - Recombinant Follistatin By SDS-PAGE
Select
E. coli
His-T7
31.4 kDa
10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164
Viewing 1-23 of 23 product results


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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).