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FLI1 is a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants.
Gene Name: | Fli-1 proto-oncogene, ETS transcription factor |
Synonyms: | FLI1, FLI-1, EWSR2, SIC-1, Proto-oncogene Fli-1, Transcription factor ERGB, Fli-1 oncogene |
Target Sequences: | NM_002017 NP_002008.2 Q01543 |
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