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FGF23

fibroblast growth factor 23

FGF23 is a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC).

Gene Name: fibroblast growth factor 23
Family/Subfamily: HBGF , not assigned-HBGF
Synonyms: FGF23, ADHR, Fibroblast growth factor 23, FGF-23, HYPF, Phosphatonin, PHPTC, HPDR2
Target Sequences: NM_020638 NP_065689.1 Q9GZV9

Publications (1)

1
MEKK2 mediates aberrant ERK activation in neurofibromatosis type I. Seoyeon Bok, Dong Yeon Shin, Alisha R Yallowitz, Mark Eiseman, Michelle Cung, Ren Xu, Na Li, Jun Sun, Alfred L Williams, John E Scott, Bing Su, Jae-Hyuck Shim, Matthew B Greenblatt. Nature communications. 2020 November;11:5704. [Full Text Article] [PubMed:33177525] [PMC:PMC7658220]

☰ Filters
Products
Proteins (18)
Over-Expression Lysate (2)
Recombinant (16)
FGF23 (18)
No (18)
GST (1)
His (5)
His, N-Terminal (1)
His,C-terminus (1)
His-T7 (1)
Human IgG1 Fc (1)
Myc-DDK (Flag) (3)
Human (12)
Mouse (3)
Rat (2)
293T Cells (1)
E. coli (11)
HEK 293 Cells (4)
Wheat Germ Extract (1)
Yeast (1)
Purified (7)
Low endotoxin level (5)
Biologically active (5)
Select
E. coli
His
29.6 kD
100 µg/$500; 1 mg/$1,679; 20 µg/$364
FGF23 Protein
Select
Yeast
His
27.5 kD
100 µg/$499; 20 µg/$364; 1 mg/$1,683
FGF23 Protein
Select
E. coli
None
Biologically active
25.3 kDa
5 µg/$282; 100 µg/$1,186; 500 µg/$2,269
FGF23 Protein - Active Fibroblast Growth Factor 23 (FGF23) by WB
Select
E. coli
His, N-Terminal
29kDa
10 µg/$285; 50 µg/$470; 200 µg/$937; 100 µg/$750; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252
FGF23 Protein - ERK and FRS2alpha phosphorylation induced by FGF-21 in Klotho expressing cells. Klotho expressing HEK 293EBNA cells were serum starved for 16 hours and then stimulated with hFGF-23-His, FGF-23-Fc and FGF-b (positive control) for 10 minutes, respectively. Antibodies against pFRS2alpha, pERK1/2 and total ERK1/2 were used for immunoblotting. Lane 1: Mock (non-treated) Lane 2: Mock + hFGF23-Fc 1 ug/ml Lane 3: Mock + hFGF23-His 1 ug/ml Lane 4: Klotho + hFGF23-Fc 1 ug/ml Lane 5: Klotho + hFGF23-Fc 4 ug/ml Lane 6: Klotho + mCD137-Fc 1 ug/ml Lane 7: Klotho (non-treated) Lane 8: Klotho + 100ng/ml FGF-b
Select
HEK 293 Cells
Human IgG1 Fc
Less than 0.1 EU/µg protein (determined by LAL method).
60kDa-40kDa
50 µg/$463; 10 µg/$330
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
22.5 kDa
5 µg/$268; 20 µg/$349
FGF23 Protein - 12.5% SDS-PAGE of human FGF23 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
54.4 kDa
10 µg/$479; 25 µg/$670
FGF23 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
25.3 kDa
20 µg/$150
FGF23 Protein - Purified recombinant protein FGF23 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
25.3 kDa
20 µg/$1,107
FGF23 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
25.3 kDa
100 µg/$494
Select
E. coli
None
Biologically active
Less than 1 EU/µg (determined by LAL method).
25.3 kDa
1 mg/$3,412; 20 µg/$364
Select
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~23 kDa
20 µg/$432; 1 mg/$6,427
Select
E. coli
None
Biologically active
25.5 kDa
20 µg/$349; 5 µg/$268
Select
HEK 293 Cells
His,C-terminus
Less than 0.01 EU/µg protein (determined by LAL method).
~30 kDa (SDS-PAGE)
10 µg/$344
FGF23 Protein - Recombinant Fibroblast Growth Factor 23 By SDS-PAGE
Select
E. coli
His
13.1 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
FGF23 Protein - Recombinant Fibroblast Growth Factor 23 By SDS-PAGE
Select
E. coli
His
10.5 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
Select
E. coli
His
11.1 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
FGF23 Protein - Recombinant Fibroblast Growth Factor 23 By SDS-PAGE
Select
E. coli
His-T7
29.1 kDa
10 µg/$281; 50 µg/$440; 100 µg/$702; 200 µg/$877; 1 mg/$1,983; 500 µg/$1,523; 5 mg/$3,067; 2 mg/$2,170
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).