FEN1

flap structure-specific endonuclease 1

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.

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Products

Antibodies (50)

Proteins (8)

ELISA Kits (6)

Type

Competitive EIA (1)

Custom (3)

Over-Expression Lysate (2)

Primary (50)

Recombinant (6)

Sandwich (2)

Target

FEN1 (64)

Reactivity

Human (52)

Mouse (29)

Rat (16)

Bat (3)

Bovine (7)

Chicken (4)

Chimpanzee (6)

Gibbon (6)

Guinea pig (3)

Hamster (1)

Horse (6)

Monkey (8)

Pig (6)

Rabbit (3)

Sheep (6)

Zebrafish (3)

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Application

IHC (17)

IHC-P (7)

WB (48)

ELISA (6)

ICC (3)

IF (10)

IP (12)

Peptide-ELISA (1)

Host

rabbit (34)

mouse (16)

Product Group

IHCPlus (3)

Isotype

IgG (26)

IgG1 (9)

IgG2a (2)

IgM,k (1)

Clonality

monoclonal mc (15)

polyclonal pc (35)

Clone

1E2 (1)

4E7 (1)

OTI1E1 (2)

OTI1F3 (2)

OTI2B2 (2)

OTI3A8 (2)

Format

96-Well Strip Plate (6)

APC Conjugated (1)

Biotin Conjugated (4)

Carrier-free (4)

FITC Conjugated (4)

HRP Conjugated (4)

PE Conjugated (2)

Preservative Free (2)

Unconjugated (35)

Epitope

aa117-380 (8)

N-Terminus (5)

aa301-350 (4)

aa1-380 (2)

aa250-300 (2)

60-140 aa, Internal (1)

Ala119 (1)

Internal (1)

aa243-272 (1)

aa75-125 (1)

aa86-135 (1)

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Publications

No (64)

Sample Type

Cell Lysates (1)

Plasma (3)

Serum (3)

Tissue Homogenates (1)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (7)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (2)

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FEN1 Antibody (aa301-350) LS-C80825

Antibody:

FEN1 Rabbit anti-Human Polyclonal (aa301-350) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$397

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IHC-plus™ FEN1 Antibody (aa1-380, clone 4E7) LS-B1694

(4.0) Rating

Antibody:

FEN1 Mouse anti-Human Monoclonal (aa1-380) (4E7) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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FEN1 Antibody (aa86-135) LS-C118882

Antibody:

FEN1 Rabbit anti-Human Polyclonal (aa86-135) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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IHC-plus™ FEN1 Antibody (aa117-380, clone OTI1E1) LS-B16831

(4.0) Rating

Antibody:

FEN1 Mouse anti-Human Monoclonal (aa117-380) (OTI1E1) Antibody

Reactivity:

Human

Applications:

IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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IHC-plus™ FEN1 Antibody (aa250-300) LS-B12760

(4.0) Rating

Antibody:

FEN1 Rabbit anti-Human Polyclonal (aa250-300) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µl/$460

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FEN1 Antibody LS-C331322

Antibody:

FEN1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, IP, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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FEN1 Antibody (Internal) LS-C352190

Antibody:

FEN1 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

ICC, IF, IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

100 µl/$299

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FEN1 Antibody LS-C822722

Antibody:

FEN1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

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FEN1 Antibody LS-C755052

Antibody:

FEN1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$331

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FEN1 Antibody (60-140 aa, Internal) LS-C383477

Antibody:

FEN1 Rabbit anti-Human Polyclonal (60-140 aa, Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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FEN1 Antibody (Ala119) LS-C176757

Antibody:

FEN1 Rabbit anti-Human Polyclonal (Ala119) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

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FEN1 Antibody (aa117-380, clone OTI1F3) LS-C336667

Antibody:

FEN1 Mouse anti-Human Monoclonal (aa117-380) (OTI1F3) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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FEN1 Antibody (aa117-380, clone OTI1F3, Carrier-free) LS-C789619

Antibody:

FEN1 Mouse anti-Human Monoclonal (aa117-380) (Carrier-free) (OTI1F3) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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FEN1 Antibody (aa243-272) LS-C97354

Antibody:

FEN1 Rabbit anti-Human Polyclonal (aa243-272) Antibody

Reactivity:

Human

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

400 µl/$393

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Human FEN1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75948

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.4 kDa

Price:

20 µg/$150

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FEN1 Antibody LS-C658775

Antibody:

FEN1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

100 µl/$386

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FEN1 Antibody LS-C766569

Antibody:

FEN1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, IP

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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FEN1 Antibody (aa117-380, clone OTI3A8) LS-C338598

Antibody:

FEN1 Mouse anti-Human Monoclonal (aa117-380) (OTI3A8) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

Select

FEN1 Antibody (aa117-380, clone OTI3A8, Carrier-free) LS-C789620

Antibody:

FEN1 Mouse anti-Human Monoclonal (aa117-380) (Carrier-free) (OTI3A8) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

FEN1 Antibody LS-C812966

Antibody:

FEN1 Mouse anti-Human Monoclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$332; 100 µg/$404; 200 µg/$505

Select

FEN1 Antibody LS-C393649

Antibody:

FEN1 Mouse anti-Human Monoclonal Antibody

Reactivity:

Mouse, Human

Applications:

ICC, WB

Format:

Unconjugated

Price:

100 µl/$391

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FEN1 Antibody LS-C192431

Antibody:

FEN1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

50 µl/$356; 100 µl/$461

Select

FEN1 Antibody (clone 1E2) LS-C197211

Antibody:

FEN1 Mouse anti-Human Monoclonal (1E2) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$423

Select

FEN1 Antibody LS-C812968

Antibody:

FEN1 Mouse anti-Human Monoclonal Antibody

Reactivity:

Mouse, Rat, Hamster, Human, Monkey

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$332; 100 µg/$406; 200 µg/$505

Select

FEN1 Antibody LS-C393650

Antibody:

FEN1 Mouse anti-Human Monoclonal Antibody

Reactivity:

Mouse, Human

Applications:

IP, WB

Format:

Unconjugated

Price:

100 µl/$391

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