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Infectious Disease
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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
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Customer Service: (800) 227-6666 / (650) 697-3600
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FASLG / Fas Ligand
Fas ligand (TNF superfamily, member 6)
Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.
| Gene Name: | Fas ligand (TNF superfamily, member 6) |
| Family/Subfamily: | TNF , not assigned-TNF |
| Synonyms: | FASLG, ALPS1B, Apoptosis antigen ligand, APTL, CD95L, CD95 ligand, CD178 antigen, CD95-L, Fas antigen ligand, Fas ligand, FASL, TNFSF6, APT1LG1, CD178 |
| Target Sequences: | NM_000639 NP_000630.1 P48023 |
Publications (9)
1
Human circulating CD4+CD25highFoxp3+ regulatory T cells kill autologous CD8+ but not CD4+ responder cells by Fas-mediated apoptosis. Strauss L, Bergmann C, Whiteside TL. Journal of immunology (Baltimore, Md. : 1950). 2009 182:1469-80.
[PubMed:19155494]
Related Antibodies: LS-C40984.
2
Lipopolysaccharide can trigger a cathepsin B-dependent programmed death response in human endothelial cells. Li JH, D'Alessio A, Pober JS. The American journal of pathology. 2009 175:1124-35.
[PubMed:19661440]
[PMC:PMC2731131]
Related Antibodies: LS-C40984.
3
Intensive resistance exercise induces lymphocyte apoptosis via cortisol and glucocorticoid receptor-dependent pathways. Krger K, Agnischock S, Lechtermann A, Tiwari S, Mishra M, Pilat C, Wagner A, Tweddell C, Gramlich I, Mooren FC. Journal of applied physiology (Bethesda, Md. : 1985). 2011 110:1226-32.
[PubMed:21393471]
Related Antibodies: LS-C40984.
☰ Filters
Products
Proteins
(20)
Type
Over-Expression Lysate
(2)
Recombinant
(18)
Target
FASLG / Fas Ligand
(20)
Publications
No
(20)
Tag
6His, N-terminus
(1)
DDK (Flag)
(1)
DDK (Flag)-Human ACRP30headless aa 18-111
(1)
GST
(1)
GST, N-terminus
(1)
His
(5)
His, N-Terminal
(2)
His-GST
(2)
His-S
(1)
His-T7
(1)
Human IgG1 Fc
(1)
Myc-DDK (Flag)
(2)
Species
Human
(16)
Mouse
(1)
Rat
(1)
Rhesus monkey
(1)
Source
293T Cells
(1)
CHO Cells
(2)
E. coli
(8)
HEK 293 Cells
(4)
Human
(1)
Wheat Germ Extract
(2)
Yeast
(2)
Purification
Purified
(4)
Low Endotoxin Level
Low endotoxin level
(6)
Biologically Active
Biologically active
(2)
CHO Cells
His, N-Terminal
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
17.9 kDa
2 µg/$268; 10 µg/$349
HEK 293 Cells
DDK (Flag)
Less than 0.05 EU/µg protein (determined by LAL method).
~33kDa (SDS-PAGE)
10 µg/$323
E. coli
His, N-Terminal
21.7 kDa
10 µg/$289; 50 µg/$492; 100 µg/$785; 200 µg/$982; 1 mg/$2,119; 500 µg/$1,646; 5 mg/$3,431; 2 mg/$2,309
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
HEK 293 Cells
Myc-DDK (Flag)
31.3 kDa
100 µg/$494
293T Cells
Myc-DDK (Flag)
31.3 kDa
20 µg/$150
Human
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
17.7 kDa
10 µg/$377; 50 µg/$818
Yeast
His
19.3 kD
100 µg/$446; 20 µg/$336; 1 mg/$1,460
Yeast
His
22.4 kD
100 µg/$446; 20 µg/$336; 1 mg/$1,460
HEK 293 Cells
DDK (Flag)-Human ACRP30headless aa 18-111
Less than 0.02 EU/µg protein (determined by LAL method).
~40kDa (SDS-PAGE)
10 µg/$435
HEK 293 Cells
Human IgG1 Fc
Less than 0.01 EU/µg protein (determined by LAL method).
~50kDa (SDS-PAGE)
10 µg/$407
Wheat Germ Extract
GST
56.65 kDa
10 µg/$479; 25 µg/$670
E. coli
His
21.4 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
E. coli
His
24.5 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
CHO Cells
None
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 157 amino acid recombinant protein has a predicted molecular mass of approximately 18 kD. The DTT-reduced and non-reduced protein migrate at approximately 29 to 30 kD by SDS-PAGE. The N-terminal amino acid is Met.
10 µg/$344; 25 µg/$451; 100 µg/$993
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
E. coli
His-GST
52.4 kDa
10 µg/$279; 50 µg/$427; 100 µg/$682; 200 µg/$852; 1 mg/$1,950; 500 µg/$1,494; 5 mg/$2,983; 2 mg/$2,136
E. coli
His-S
14.3 kDa
10 µg/$279; 50 µg/$427; 100 µg/$682; 200 µg/$852; 1 mg/$1,950; 500 µg/$1,494; 5 mg/$2,983; 2 mg/$2,136
E. coli
His-GST
52.2 kDa
10 µg/$283; 50 µg/$457; 100 µg/$732; 200 µg/$912; 1 mg/$2,032; 500 µg/$1,567; 5 mg/$3,193; 2 mg/$2,219
E. coli
His-T7
49.3 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
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