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F8 / FVIII / Factor VIII
coagulation factor VIII, procoagulant component
F8 / FVIII / Factor VIII is coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.
| Gene Name: | coagulation factor VIII, procoagulant component |
| Synonyms: | F8, AHF, Antihemophilic factor, Coagulation factor VIIIc, Coagulation factor VIII, DXS1253E, Factor VIII F8B, FVIII, HEMA, F8B, Factor VIII, Procoagulant component, F8C |
| Target Sequences: | NM_000132 NP_000123.1 P00451 |
Publications (2)
1
Von Willebrand and Factor VIII Portosystemic Circulation Gradient in Cirrhosis: Implications for Portal Vein Thrombosis. Von Willebrand and Factor VIII Portosystemic Circulation Gradient in Cirrhosis: Implications for Portal Vein Thrombosis. Clinical and translational gastroenterology. 2020 February;11:e00123. [Full Text Article]
[PubMed:32032127]
[PMC:PMC7145026]
2
IL-15 blockade and rapamycin rescue multifactorial loss of factor VIII from AAV-transduced hepatocytes in hemophilia A mice. John S S Butterfield, Kentaro Yamada, Thais B Bertolini, Farooq Syed, Sandeep R P Kumar, Xin Li, Sreevani Arisa, Annie R Piñeros, Alejandro Tapia, Christopher A Rogers, Ning Li, Jyoti Rana, Moanaro Biswas, Cox Terhorst, Randal J Kaufman, Ype P de Jong, Roland W Herzog. Molecular therapy : the journal of the American Society of Gene Therapy. 2022 December;30:3552-3569. [Full Text Article]
[PubMed:35821634]
[PMC:PMC9734025]
Related Antibodies: LS-B2979.
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(107)
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F8 / FVIII / Factor VIII
(107)
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(90)
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(68)
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(34)
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(22)
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(14)
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(5)
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(38)
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(69)
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(1)
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(1)
402
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(11)
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(13)
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(9)
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(45)
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(8)
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(8)
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(8)
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(4)
2130-2210 aa, C-terminal
(1)
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(1)
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(1)
aa1264-1278
(1)
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(1)
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Publications
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(106)
Yes
(1)
F8 / FVIII / Factor VIII Sheep anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
0.5 mg/$440
Cancer
F8 / FVIII / Factor VIII Mouse anti-Human Monoclonal (F8 2.2.9) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$495
F8 / FVIII / Factor VIII Rabbit anti-Pig Polyclonal (aa1669-1824) Antibody
Pig
IHC, IHC-P, WB
Unconjugated
100 µl/$460
F8 / FVIII / Factor VIII Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
0.1 mg/$432
F8 / FVIII / Factor VIII Rabbit anti-Human Polyclonal (aa1790-1839) Antibody
Human
WB
Unconjugated
100 µl/$424
F8 / FVIII / Factor VIII Sheep anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IE
HRP Conjugated
200 µg/$657
F8 / FVIII / Factor VIII Rabbit anti-Human Polyclonal (Ser2194) Antibody
Mouse, Human
WB
Unconjugated
50 µl/$321; 100 µl/$403
F8 / FVIII / Factor VIII Rabbit anti-Pig Polyclonal (aa1669-1824) (Biotin) Antibody
Pig
WB
Biotin Conjugated
100 µl/$334; 200 µl/$387; 500 µl/$563; 1 ml/$678; 2 ml/$915; 5 ml/$1,541
F8 / FVIII / Factor VIII Rabbit anti-Human Polyclonal (aa2187-2209) Antibody
Mouse, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
F8 / FVIII / Factor VIII Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Dog, Human
WB
Unconjugated
100 µl/$299
F8 / FVIII / Factor VIII Rabbit anti-Human Polyclonal (PE) Antibody
Human
WB
PE Conjugated
100 µl/$937
F8 / FVIII / Factor VIII Rabbit anti-Human Monoclonal Antibody
Human
ELISA
Unconjugated
100 µl/$412
F8 / FVIII / Factor VIII Rabbit anti-Mouse Polyclonal (aa1854-1989) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
F8 / FVIII / Factor VIII Rabbit anti-Mouse Polyclonal (aa1854-1989) (Biotin) Antibody
Mouse, Human
WB
Biotin Conjugated
100 µl/$316; 200 µl/$361; 500 µl/$511; 1 ml/$587; 2 ml/$809; 5 ml/$1,317
F8 / FVIII / Factor VIII Mouse anti-Human Monoclonal (F8C 27.4 (2A5)) Antibody
Human
ELISA
Unconjugated
0.2 mg/$486
F8 / FVIII / Factor VIII Rabbit anti-Human Polyclonal (2130-2210 aa, C-terminal) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
F8 / FVIII / Factor VIII Rat anti-Mouse Monoclonal (9035) Antibody
Mouse
ELISA, IHC-P, WB
Unconjugated
100 µg/$567
F8 / FVIII / Factor VIII Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
500 µg/$860
F8 / FVIII / Factor VIII Mouse anti-Human Monoclonal (5E9B2) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$435
F8 / FVIII / Factor VIII Rabbit anti-Human Polyclonal (aa2253-2346) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543; 2 ml/$715; 5 ml/$1,182
F8 / FVIII / Factor VIII Rabbit anti-Human Polyclonal (aa2253-2346) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$313; 200 µl/$357; 500 µl/$503; 1 ml/$576; 2 ml/$788; 5 ml/$1,279
F8 / FVIII / Factor VIII Mouse anti-Human Monoclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
100 µl/$951
F8 / FVIII / Factor VIII Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
F8 / FVIII / Factor VIII Rabbit anti-Human Polyclonal (aa1887-2044) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$331; 200 µl/$383; 500 µl/$556; 1 ml/$665; 2 ml/$901; 5 ml/$1,511
F8 / FVIII / Factor VIII Rabbit anti-Human Polyclonal (aa1887-2044) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$313; 200 µl/$357; 500 µl/$503; 1 ml/$576; 2 ml/$788; 5 ml/$1,279
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