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F2 / Prothrombin / Thrombin
coagulation factor II (thrombin)
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Finally, peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.
| Gene Name: | coagulation factor II (thrombin) |
| Family/Subfamily: | Protease , Serine S1 |
| Synonyms: | F2, Prothrombin B-chain, Coagulation factor II, FACTOR II, Prothrombin, PT, RPRGL2, Serine protease, THPH1, Thrombin |
| Target Sequences: | NM_000506 NP_000497.1 P00734 |
Publications (3)
1
Targeting the thrombin receptor modulates inflammation and astrogliosis to improve recovery after spinal cord injury. Radulovic M, Yoon H, Wu J, Mustafa K, Scarisbrick IA. Neurobiology of disease. 2016 93:226-42. (WB; Human)
[Full Text Article]
[PubMed:27145117]
Related Antibodies: LS-C118750.
2
Production and control of coagulation proteins for factor X activation in human endothelial cells and fibroblasts. Clay T Cohen, Nancy A Turner, Joel L Moake. Scientific reports. 2020 Feb;10:2005. [Full Text Article]
[PubMed:32029851]
[PMC:PMC7005260]
3
Maternal plasma proteomics in a rat model of pregnancy complications reveals immune and pro-coagulant gene pathway activation. Tino W Sanchez, Bo Li, Christine Molinaro, Carlos A Casiano, Denise L Bellinger, Eugenia Mata-Greenwood. American journal of reproductive immunology (New York, N.Y. : 1989). 2020 February;83:e13205. [Full Text Article]
[PubMed:31677200]
[PMC:PMC8553409]
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F2 / Prothrombin / Thrombin Rabbit anti-Human Polyclonal (aa391-440) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
F2 / Prothrombin / Thrombin Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
F2 / Prothrombin / Thrombin Sheep anti-Bovine Polyclonal Antibody
Bovine, Human
ELISA, IHC, IHC-P
Unconjugated
250 µg/$485
F2 / Prothrombin / Thrombin Mouse anti-Human Monoclonal (AHP-5013) Antibody
Human
ELISA, Inhb, WB
Unconjugated
100 µg/$515
F2 / Prothrombin / Thrombin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$440; 1 mg/$594; 10 mg/$3,400
F2 / Prothrombin / Thrombin Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
100 µg/$440; 1 mg/$594; 10 mg/$3,612
F2 / Prothrombin / Thrombin Sheep anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IE
HRP Conjugated
200 µg/$657
F2 / Prothrombin / Thrombin Sheep anti-Bovine Polyclonal (HRP) Antibody
Bovine
ELISA, IE
HRP Conjugated
200 µg/$665
F2 / Prothrombin / Thrombin Sheep anti-Human Polyclonal Antibody
Human
Unconjugated
10 mg/$515
F2 / Prothrombin / Thrombin Sheep anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
200 µg/$657
F2 / Prothrombin / Thrombin Sheep anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.5 mg/$485
F2 / Prothrombin / Thrombin Rabbit anti-Human Polyclonal (aa396-445) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
Sandwich
96-Well Strip Plate
Human
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$585
Sandwich
96-Well Strip Plate
Human
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Sandwich
96-Well Microplate
Human
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
E. coli
6His, N-terminus
67.6 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
Sandwich
96-Well Strip Plate
Bovine
7.8 - 500 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
F2 / Prothrombin / Thrombin Sheep anti-Bovine Polyclonal Antibody
Bovine
ELISA
Unconjugated
1 mg/$459
F2 / Prothrombin / Thrombin Rabbit anti-Human Polyclonal (Gly724) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
Sandwich
96-Well Strip Plate
Rat
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
E. coli
His-T7
20.9 kDa
50 µg/$442; 10 µg/$281; 200 µg/$882; 100 µg/$705; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
F2 / Prothrombin / Thrombin Rabbit anti-Rat Polyclonal (aa130-179) Antibody
Rat
WB
Unconjugated
100 µl/$424
F2 / Prothrombin / Thrombin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
E. coli
His
19.1 kDa
10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
F2 / Prothrombin / Thrombin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µl/$440; 1 ml/$594; 10 ml/$3,707
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