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ERBB3 / HER3
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
ERBB3 / HER3 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
| Gene Name: | v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 |
| Family/Subfamily: | Protein Kinase , EGF Receptor |
| Synonyms: | ERBB3, C-erbB-3, C-erbB3, ErbB-3, HER3, p85-sErbB3, p45-sErbB3, MDA-BF-1, ErbB3-S, LCCS2, p180-ErbB3 |
| Target Sequences: | NM_001982 NP_001973.2 P21860 |
Publications (2)
1
High incidence of ErbB3, ErbB4, and MET expression in ovarian cancer. Davies S, Holmes A, Lomo L, Steinkamp MP, Kang H, Muller CY, Wilson BS. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. 2014 33:402-10. (IHC; Human)
[Full Text Article]
[PubMed:24901400]
[PMC:PMC4153698]
Related Antibodies: LS-B2126.
2
Uncoupling of EGFR-RAS signaling and nuclear localization of YBX1 in colorectal cancer. Roßner F, Gieseler C, Morkel M, Royer HD, Rivera M, Bläker H, Dietel M, Schäfer R, Sers C. Oncogenesis. 2016 5:e187. (IHC, WB; Human)
[Full Text Article]
[PubMed:26779809]
[PMC:PMC4728680]
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(12)
Cancer
ERBB3 / HER3 Goat anti-Human Polyclonal (aa1300-C-term) Antibody
Rat, Hamster, Pig, Horse, Bat, Human, Monkey
IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
100 µg/$485
ERBB3 / HER3 Mouse anti-Human Monoclonal (2E9) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
ERBB3 / HER3 Mouse anti-Human Monoclonal (3F10F6) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
ERBB3 / HER3 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
ERBB3 / HER3 Rabbit anti-Human Polyclonal (aa24-55) Antibody
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
ERBB3 / HER3 Rabbit anti-Human Polyclonal (pTyr1222) Antibody
Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
Cell-Based Phosphorylation
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
ERBB3 / HER3 Rabbit anti-Human Monoclonal (pTyr1222) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$702
ERBB3 / HER3 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Zebrafish, Rat, Mouse, Bovine, Human, Monkey
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$315
ERBB3 / HER3 Mouse anti-Human Monoclonal (3F12) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$460
Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
ERBB3 / HER3 Rabbit anti-Human Polyclonal (1-80 aa, N-terminal) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
ERBB3 / HER3 Rabbit anti-Human Polyclonal (pTyr1289) Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
ERBB3 / HER3 Mouse anti-Human Monoclonal (2C7) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$460
ERBB3 / HER3 Mouse anti-Rat Monoclonal (Azide-free) Antibody
Mouse, Bovine, Rat, Human
IP, WB
Unconjugated, Azide-free
500 µl/$892
ERBB3 / HER3 Rabbit anti-Mouse Monoclonal (Preservative Free) (128) Antibody
Mouse
ELISA
Unconjugated, Preservative Free
20 µl/$271; 100 µl/$412
ERBB3 / HER3 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$321
ERBB3 / HER3 Rabbit anti-Human Monoclonal (Preservative Free) (015) Antibody
Human
ELISA
Unconjugated, Preservative Free
20 µl/$271; 100 µl/$412
ERBB3 / HER3 Rabbit anti-Human Polyclonal (p1289) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
ERBB3 / HER3 Rabbit anti-Mouse Polyclonal (aa707-964) (Biotin) Antibody
Mouse
WB
Biotin Conjugated
100 µl/$321; 200 µl/$369; 500 µl/$527; 1 ml/$611; 2 ml/$842; 5 ml/$1,387
ERBB3 / HER3 Rabbit anti-Human Polyclonal (aa1191-1240) Antibody
Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
ERBB3 / HER3 Rabbit anti-Human Polyclonal (aa1256-1305) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
ERBB3 / HER3 Rabbit anti-Human Polyclonal (1160-1240 aa) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
ERBB3 / HER3 Rabbit anti-Human Polyclonal (1230-1310 aa) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
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