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EPHA3 / EPH Receptor A3
EPH receptor A3
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.
| Gene Name: | EPH receptor A3 |
| Family/Subfamily: | Protein Kinase , Ephrin Receptor |
| Synonyms: | EPHA3, CEK4 kinase, EPH receptor A3, Ephrin type-A receptor 3, Eph-like tyrosine kinase 1, ETK1, HEK4, EPH-like kinase 4, HEK, Human embryo kinase 1, MEK4 kinase, Human embryo kinase, Tyrosine-protein kinase TYRO4, TYRO4, EK4, Eph kinase A3, ETK |
| Target Sequences: | NM_005233 NP_005224.2 P29320 |
Publications (1)
1
A molecular mechanism for the topographic alignment of convergent neural maps. Savier E, Eglen SJ, Bathélémy A, Perraut M, Pfrieger FW, Lemke G, Reber M. eLife. 2017 March;6:pii: e20470. (Mouse, Human)
[Full Text Article]
[PubMed:28322188]
[PMC:PMC5360444]
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EPHA3 / EPH Receptor A3 Rabbit anti-Human Polyclonal (aa115-144) Antibody
Human
IHC, IHC-P, WB
Unconjugated
200 µl/$460
EPHA3 / EPH Receptor A3 Rabbit anti-Human Polyclonal (aa896-928) Antibody
Hamster, Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
EPHA3 / EPH Receptor A3 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$450
EPHA3 / EPH Receptor A3 Mouse anti-Human Monoclonal (C-Terminus) Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$748
EPHA3 / EPH Receptor A3 Rabbit anti-Human Polyclonal (Internal) Antibody
Chicken, Mouse, Rat, Human, Monkey
ICC, IF, WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
EPHA3 / EPH Receptor A3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
EPHA3 / EPH Receptor A3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
EPHA3 / EPH Receptor A3 Rabbit anti-Human Polyclonal (aa896-928) Antibody
Hamster, Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
EPHA3 / EPH Receptor A3 Rabbit anti-Human Polyclonal (aa896-928) (Biotin) Antibody
Hamster, Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
EPHA3 / EPH Receptor A3 Rabbit anti-Human Polyclonal (aa896-928) (FITC) Antibody
Hamster, Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
EPHA3 / EPH Receptor A3 Rabbit anti-Human Polyclonal (aa896-928) (PE) Antibody
Hamster, Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
EPHA3 / EPH Receptor A3 Rabbit anti-Human Polyclonal (aa896-928) (APC) Antibody
Hamster, Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
EPHA3 / EPH Receptor A3 Rabbit anti-Human Polyclonal (aa896-928) (Azide-free) (HRP) Antibody
Hamster, Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
EPHA3 / EPH Receptor A3 Rabbit anti-Human Polyclonal (aa115-144) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
EPHA3 / EPH Receptor A3 Rabbit anti-Human Polyclonal (aa115-144) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
EPHA3 / EPH Receptor A3 Rabbit anti-Human Polyclonal (aa115-144) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
EPHA3 / EPH Receptor A3 Rabbit anti-Human Polyclonal (aa115-144) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
EPHA3 / EPH Receptor A3 Rabbit anti-Human Polyclonal (aa115-144) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
EPHA3 / EPH Receptor A3 Rabbit anti-Human Polyclonal (aa115-144) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
EPHA3 / EPH Receptor A3 Mouse anti-Human Monoclonal (3A12) Antibody
Human
ELISA, RNAi, WB
Unconjugated
100 µg/$423
EPHA3 / EPH Receptor A3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
EPHA3 / EPH Receptor A3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
EPHA3 / EPH Receptor A3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
EPHA3 / EPH Receptor A3 Mouse anti-Human Monoclonal (6C1B6) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$435
EPHA3 / EPH Receptor A3 Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
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