DNASE1 / DNase I

deoxyribonuclease I

DNASE1 / DNase I is a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

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Products

Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

DNASE1 / DNase I (7)

Publications

No (7)

Tag

GST, N-terminus (1)

GST, N-terminus + His, C-terminus (1)

His (1)

His, C-Terminal (1)

His, N-Terminal (1)

Myc-DDK (Flag) (2)

Species

Human (6)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (1)

Human Cells (1)

Wheat Germ Extract (1)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (1)

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Human DNASE1 / DNase I Protein (Recombinant His, C-Terminal) (Met1-Lys282) - LS-G97388

Source:

Human Cells

Tag:

His, C-Terminal

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

30.7 kDa

Price:

100 µg/$843

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Human DNASE1 / DNase I Protein (Recombinant His, N-Terminal) - LS-G132750

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

28kDa

Price:

10 µg/$291; 50 µg/$505; 200 µg/$1,008; 100 µg/$807; 1 mg/$2,153; 500 µg/$1,676; 5 mg/$3,529; 2 mg/$2,344

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Human DNASE1 / DNase I Protein (Recombinant His) (aa19-259) - LS-G13376

Source:

E. coli

Tag:

His

Molecular Weight:

28.6 kDa

Price:

10 µg/$255; 50 µg/$323; 100 µg/$450; 200 µg/$562; 1 mg/$1,480; 500 µg/$1,096; 5 mg/$2,395; 2 mg/$1,646

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Human DNASE1 / DNase I Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87879

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

31.43 kDa

Price:

20 µg/$150

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DNASE1 / DNase I Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100485

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

31.43 kDa

Price:

100 µg/$494

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Human DNASE1 / DNase I Protein (Recombinant GST, N-terminus + His, C-terminus) - LS-G144701

Source:

E. coli

Tag:

GST, N-terminus + His, C-terminus

Molecular Weight:

55.2 kDa

Price:

50 µg/$419

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Human DNASE1 / DNase I Protein (Recombinant GST, N-terminus) (Full Length) - LS-G28224

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Molecular Weight:

57.8 kDa

Price:

10 µg/$479; 25 µg/$670

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