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DNASE1 / DNase I

deoxyribonuclease I

DNASE1 / DNase I is a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Gene Name: deoxyribonuclease I
Synonyms: DNASE1, Deoxyribonuclease I, Deoxyribonuclease i precursor, DNase I, DNL1, DRNI, Deoxyribonuclease-1, DNase I, lysosomal
Target Sequences: NM_005223 NP_005214.2 P24855

Publications (5)

1
TNFα Amplifies DNaseI Expression in Renal Tubular Cells while IL-1β Promotes Nuclear DNaseI Translocation in an Endonuclease-Inactive Form. Thiyagarajan D, Rekvig OP, Seredkina N. PloS one. 2015 10:e0129485. (IHC, WB; Mouse, Human) [Full Text Article] [PubMed:26065428] [PMC:PMC4465975] Related Antibodies: LS-B4846.
2
IL-1ß Promotes a New Function of DNase I as a Transcription Factor for the Fas Receptor Gene. Thiyagarajan D, Pedersen HL, Seredkina N, Horvei KD, Arranz L, Sonneveld R, Nijenhuis T, van der Vlag J, Rekvig OP. Frontiers in cell and developmental biology. 2018 February;6:7. (Human) [Full Text Article] [PubMed:29468159] [PMC:PMC5807897] Related Antibodies: LS-B4846.
3
Lupus nephritis: low urinary DNase I levels reflect loss of renal DNase I and may be utilized as a biomarker of disease progression. Pedersen HL, Horvei KD, Thiyagarajan D, Norby GE, Seredkina N, Moroni G, Eilertsen GØ, Holdaas H, Strøm EH, Bakland G, Meroni PL, Rekvig OP. The journal of pathology Clinical research. 2018 July;4:193-203. [Full Text Article] [PubMed:29624903] [PMC:PMC6065113] Related Antibodies: LS-B4846.
4
Neutrophil extracellular trap formation in the Streptococcus suis-infected cerebrospinal fluid compartment. Nicole de Buhr, Friederike Reuner, Ariane Neumann, Carolin Stump-Guthier, Tobias Tenenbaum, Horst Schroten, Hiroshi Ishikawa, Kristin Müller, Andreas Beineke, Isabel Hennig-Pauka, Thomas Gutsmann, Peter Valentin-Weigand, Christoph G Baums, Maren von Köckritz-Blickwede. Cellular microbiology. 2017 February;19: [Full Text Article] [PubMed:27450700]
5
Neutrophil Extracellular Traps Profiles in Patients with Incident Systemic Lupus Erythematosus and Lupus Nephritis. Maurizio Bruschi, Alice Bonanni, Andrea Petretto, Augusto Vaglio, Federico Pratesi, Laura Santucci, Paola Migliorini, Roberta Bertelli, Maricla Galetti, Silvana Belletti, Lorenzo Cavagna, Gabriella Moroni, Franco Franceschini, Micaela Fredi, Giulia Pazzola, Landino Allegri, Renato Alberto Sinico, Giampaola Pesce, Marcello Bagnasco, Angelo Manfredi, Giuseppe A Ramirez, Paola Ramoino, Paolo Bianchini, Francesco Puppo, Francesca Pupo, Simone Negrini, Federico Mattana, Giacomo Emmi, Giacomo Garibott. The Journal of rheumatology. 2020 Mar;47:377-386. [Full Text Article] [PubMed:31092713] [PMC:PMC6917988]
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DNASE1 / DNase I (24)
Human (7)
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DNASE1 / DNase I ELISA Kit
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96-Well Strip Plate
Bovine
15.6 - 1000 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$816
DNASE1 / DNase I ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
DNASE1 / DNase I ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
DNASE1 / DNase I ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$587
DNASE1 / DNase I ELISA Kit
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Sandwich
96-Well Strip Plate
Bovine
12.5 - 800 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$1,041
DNASE1 / DNase I ELISA Kit
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Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Saliva, Seminal Plasma, Serum, Urine
1 Plate/$798
DNASE1 / DNase I ELISA Kit
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Sandwich
96-Well Microplate
Human
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
DNASE1 / DNase I ELISA Kit
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Sandwich
96-Well Microplate
Mouse
1.25 - 80 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
DNASE1 / DNase I ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
1.25 - 80 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
DNASE1 / DNase I ELISA Kit
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Sandwich
96-Well Strip Plate
Pig
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
DNASE1 / DNase I ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Rat
78.125 - 5000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
DNASE1 / DNase I ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
DNASE1 / DNase I ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Mouse
0.313 - 20 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
DNASE1 / DNase I ELISA Kit
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Sandwich
96-Well Strip Plate
Human
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$968
DNASE1 / DNase I ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
1.25 - 80 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$715
DNASE1 / DNase I ELISA Kit
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Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$669
DNASE1 / DNase I ELISA Kit
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Custom
96-Well Strip Plate
Chicken
Colorimetric - 450nm (TMB)
1 Plate/$783
DNASE1 / DNase I ELISA Kit
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Custom
96-Well Strip Plate
Dog
Colorimetric - 450nm (TMB)
1 Plate/$783
DNASE1 / DNase I ELISA Kit
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Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$669
DNASE1 / DNase I ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.391 - 25 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
DNASE1 / DNase I ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
DNASE1 / DNase I ELISA Kit
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Sandwich
96-Well Microplate
Rat
0.391 - 25 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
DNASE1 / DNase I ELISA Kit
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Competitive EIA
96-Well Strip Plate
Human
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
DNASE1 / DNase I ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
10 - 250 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).