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DLK1 / Pref-1
delta-like 1 homolog (Drosophila)
DLK1 / Pref-1 is a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes; it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity. The mode of inheritance for this polymorphism is polar overdominance; this non-Mendelian inheritance pattern was first described in sheep with the callipyge phenotype, which is characterized by muscle hypertrophy and decreased fat mass.
| Gene Name: | delta-like 1 homolog (Drosophila) |
| Synonyms: | DLK1, Delta-like protein dlk, DLK-1, Delta1, FA1, Dlk, Preadipocyte factor 1, Pref-1, Protein delta homolog 1, PG2, ZOG, Fetal antigen 1, PREF1, Secredeltin |
| Target Sequences: | NM_003836 NP_003827.3 P80370 |
Publications (2)
1
Glucocorticoid receptor-PPARα axis in fetal mouse liver prepares neonates for milk lipid catabolism. Rando G, Tan CK, Khaled N, Montagner A, Leuenberger N, Bertrand-Michel J, Paramalingam E, Guillou H, Wahli W. eLife. 2016 5: (Flo)
[Full Text Article]
[PubMed:27367842]
[PMC:PMC4963200]
Related Antibodies: LS-C179444.
2
Hypoxia-induced release, nuclear translocation, and signaling activity of a DLK1 intracellular fragment in glioma. Elisa Stellaria Grassi, Vasiliki Pantazopoulou, Alexander Pietras. Oncogene. 2020 May;39:4028-4044. [Full Text Article]
[PubMed:32205867]
[PMC:PMC7220882]
Related Antibodies: LS-C179442.
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(99)
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DLK1 / Pref-1 Mouse anti-Human Monoclonal (Extracellular Domain) (PF299-1) Antibody
Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
50 µg/$460
DLK1 / Pref-1 Mouse anti-Human Monoclonal (Extracellular Domain) (PF13-3) Antibody
Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
50 µg/$460
DLK1 / Pref-1 Rat anti-Mouse Monoclonal (24-11) Antibody
Mouse
Flo, IHC, IHC-Fr, IHC-P
Unconjugated
100 µg/$430
DLK1 / Pref-1 Rabbit anti-Human Polyclonal (Extracellular Domain) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
DLK1 / Pref-1 Mouse anti-Human Monoclonal (3A10) Antibody
Human
ELISA, Flo, IF, WB
Unconjugated
100 µl/$459
DLK1 / Pref-1 Rat anti-Mouse Monoclonal (FITC) (24-11) Antibody
Mouse
Flo
FITC Conjugated
100 µl/$430
DLK1 / Pref-1 Rat anti-Mouse Monoclonal (PE) (24-11) Antibody
Mouse
Flo
PE Conjugated
1 ml/$451
DLK1 / Pref-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
DLK1 / Pref-1 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
Sandwich
96-Well Microplate
Human
0.41 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$635
HEK 293 Cells
Human IgG1 Fc
Less than 0.01 EU/µg protein (determined by LAL method).
~65kDa (SDS-PAGE)
10 µg/$379
Sandwich
96-Well Strip Plate
Mouse
1.56 - 100 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Urine
1 Plate/$811
HEK 293 Cells
Human IgG1 Fc
Less than 0.1 EU/µg protein (determined by LAL method).
~75kDa (SDS-PAGE)
10 µg/$379
DLK1 / Pref-1 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
DLK1 / Pref-1 Rabbit anti-Human Polyclonal (aa177-326) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
DLK1 / Pref-1 Rat anti-Human Polyclonal (Extracellular Domain) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µg/$407
DLK1 / Pref-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$286; 100 µl/$321
DLK1 / Pref-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
DLK1 / Pref-1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$832
DLK1 / Pref-1 Rabbit anti-Human Polyclonal (aa251-300) Antibody
Human
WB
Unconjugated
100 µl/$424
E. coli
His-T7
27.9 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
DLK1 / Pref-1 Rat anti-Mouse Monoclonal (PF183E) Antibody
Mouse
ELISA, WB
Unconjugated
100 µg/$407
DLK1 / Pref-1 Rat anti-Mouse Monoclonal (Extracellular Domain) (PF105B) Antibody
Mouse
ELISA, WB
Unconjugated
50 µg/$340; 100 µg/$407
DLK1 / Pref-1 Mouse anti-Human Monoclonal (3A10) Antibody
Mouse, Human
Flo, ICC, IF, WB
Unconjugated
100 µl/$541
DLK1 / Pref-1 Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, IF, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
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