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Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel.
Gene Name: | discs, large homolog 1 (Drosophila) |
Family/Subfamily: | MAGUK |
Synonyms: | DLG1, DJ1061C18.1.1, Disks large homolog 1, DLGH1, Hdlg, Presynaptic protein SAP97, SAP-97, SAP97, Synapse-associated protein 97 |
Target Sequences: | NM_004087 NP_004078.2 Q12959 |
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