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6737 Mowry Ave
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DKK1
dickkopf WNT signaling pathway inhibitor 1
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
| Gene Name: | dickkopf WNT signaling pathway inhibitor 1 |
| Synonyms: | DKK1, Dickkopf-1 like, DKK-1, Dickkopf-1, Dickkopf-related protein 1, Dickkopf related protein-1, HDkk-1, Hdkk1, Dickkopf-like protein 1, SK |
| Target Sequences: | NM_012242 NP_036374.1 O94907 |
Publications (5)
1
Dickkopf-1 is oncogenic and involved in invasive growth in non small cell lung cancer. Li S, Qin X, Guo X, Cui A, He Y, Wei S, Wang X, Shan B. PloS one. 2014 8:e84944. (WB; Human)
[Full Text Article]
[PubMed:24391982]
[PMC:PMC3877398]
Related Antibodies: LS-C201644.
2
Molecular Characterization of Microtubule Affinity-Regulating Kinase4 from Sus scrofa and Promotion of Lipogenesis in Primary Porcine Placental Trophoblasts. Tian L, Wen A, Dong S, Yan P. International journal of molecular sciences. 2019 March;20:pii E1206. [Full Text Article]
[PubMed:30857324]
[PMC:PMC6429113]
Related Antibodies: LS-B194.
3
Development of a micro-tissue-mediated injectable bone tissue engineering strategy for large segmental bone defect treatment. Wu D, Wang Z, Wang J, Geng Y, Zhang Z, Li Y, Li Q, Zheng Z, Cao Y, Zhang ZY. Stem cell research & therapy. 2018 November;9:331. [Full Text Article]
[PubMed:30486863]
[PMC:PMC6263540]
Related Antibodies: LS-C47394.
☰ Filters
Products
Proteins
(21)
Type
Over-Expression Lysate
(2)
Recombinant
(19)
Target
DKK1
(21)
Publications
No
(21)
Tag
6His, C-terminus
(1)
6His, N-terminus
(2)
8His, N-terminus
(1)
AVI-6His, C-terminus
(1)
DDK,C-terminus
(1)
Fc, C-terminus
(1)
GST
(1)
GST, N-terminus
(1)
His
(3)
His, N-Terminal
(1)
His,C-terminus
(1)
His,N-terminus
(1)
His-GST
(1)
His-GST, N-terminus
(1)
Myc-DDK (Flag)
(2)
Species
Human
(17)
Mouse
(1)
Rat
(1)
Source
293T Cells
(1)
Baculovirus
(1)
CHO Cells
(1)
E. coli
(7)
HEK 293 Cells
(4)
Human
(2)
Human Cells
(1)
Mammalian Cells
(1)
Sf9 Cells
(1)
Wheat Germ Extract
(2)
Purification
Purified
(7)
Low Endotoxin Level
Low endotoxin level
(9)
Biologically Active
Biologically active
(3)
E. coli
6His, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
HEK 293 Cells
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
35-40 kDa
2 µg/$268; 10 µg/$349
Baculovirus
His
Less than 1.0 EU/µg protein (determined by LAL method).
10 µg/$311; 50 µg/$498
Human Cells
8His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
27kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,353
Wheat Germ Extract
GST
55 kDa
2 µg/$439
293T Cells
Myc-DDK (Flag)
28.67 kDa
20 µg/$150
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
HEK 293 Cells
Myc-DDK (Flag)
28.67 kDa
100 µg/$494
HEK 293 Cells
6His, C-terminus
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
38-40 kDa
10 µg/$257; 1 mg/$1,871; 50 µg/$355
Human
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
52.7 kDa
10 µg/$271; 50 µg/$391
Human
AVI-6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
28.4 kDa
20 µg/$416; 100 µg/$910
E. coli
His-GST, N-terminus
54.3kDa
10 µg/$281; 50 µg/$440; 200 µg/$877; 100 µg/$702; 1 mg/$1,983; 500 µg/$1,523; 5 mg/$3,067; 2 mg/$2,170
Mammalian Cells
His,N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
27 kDa
10 µg/$317; 50 µg/$524
Sf9 Cells
DDK,C-terminus
25.7 kDa
20 µg/$677
E. coli
6His, N-terminus
26 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
CHO Cells
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
19-20 kDa (SDS-PAGE)
50 µg/$478; 10 µg/$300; 1 mg/$2,976
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
25.8 kDa
20 µg/$392; 100 µg/$626
E. coli
His, N-Terminal
33kDa
10 µg/$337; 50 µg/$792; 200 µg/$1,419; 100 µg/$1,203; 1 mg/$2,715; 500 µg/$2,211; 5 mg/$5,545; 2 mg/$2,957
E. coli
His
27.2 kDa
10 µg/$268; 50 µg/$362; 100 µg/$577; 200 µg/$722; 1 mg/$1,755; 500 µg/$1,325; 5 mg/$2,708; 2 mg/$1,934
E. coli
His-GST
56.3 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
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product results
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