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DKK1

dickkopf WNT signaling pathway inhibitor 1

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.

Gene Name: dickkopf WNT signaling pathway inhibitor 1
Synonyms: DKK1, Dickkopf-1 like, DKK-1, Dickkopf-1, Dickkopf-related protein 1, Dickkopf related protein-1, HDkk-1, Hdkk1, Dickkopf-like protein 1, SK
Target Sequences: NM_012242 NP_036374.1 O94907

Publications (5)

1
Dickkopf-1 is oncogenic and involved in invasive growth in non small cell lung cancer. Li S, Qin X, Guo X, Cui A, He Y, Wei S, Wang X, Shan B. PloS one. 2014 8:e84944. (WB; Human) [Full Text Article] [PubMed:24391982] [PMC:PMC3877398] Related Antibodies: LS-C201644.
2
Molecular Characterization of Microtubule Affinity-Regulating Kinase4 from Sus scrofa and Promotion of Lipogenesis in Primary Porcine Placental Trophoblasts. Tian L, Wen A, Dong S, Yan P. International journal of molecular sciences. 2019 March;20:pii E1206. [Full Text Article] [PubMed:30857324] [PMC:PMC6429113] Related Antibodies: LS-B194.
3
Development of a micro-tissue-mediated injectable bone tissue engineering strategy for large segmental bone defect treatment. Wu D, Wang Z, Wang J, Geng Y, Zhang Z, Li Y, Li Q, Zheng Z, Cao Y, Zhang ZY. Stem cell research & therapy. 2018 November;9:331. [Full Text Article] [PubMed:30486863] [PMC:PMC6263540] Related Antibodies: LS-C47394.
4
Differential expression of Dickkopf-1 among non-small cell lung cancer cells. Xiang XJ, Liu YW, Chen DD, Yu S. Molecular medicine reports. 2015 August;12:1935-1940. [Full Text Article] [PubMed:25901391]
5
Maternal obesity stimulates lipotoxicity and up-regulates inflammatory signaling pathways in the full-term swine placenta. Tian Liang, Xie Jinglong, Dong Shusheng, Wen Aiyou. Animal science journal = Nihon chikusan Gakkaiho. 2018 September;89:1310-1322. [Full Text Article] [PubMed:29947166] Related Antibodies: LS-B194.
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DKK1 (29)
Human (10)
Mouse (10)
Rat (6)
Chicken (1)
Monkey (1)
Porcine (1)
12 x 8-Well Microstrips (3)
96-Well Microplate (8)
96-Well Strip Plate (18)
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Cell Culture Supernatants (9)
Cell Lysates (3)
Plasma (26)
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Tissue Homogenates (6)
DKK1 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$563
DKK1 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
46.9 - 3000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$699
DKK1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$764
DKK1 ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
DKK1 ELISA Kit
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Sandwich
12 x 8-Well Microstrips
Human
63 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum
1 Plate/$534
DKK1 ELISA Kit
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Sandwich
96-Well Microplate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$699
DKK1 ELISA Kit
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Sandwich
96-Well Microplate
Human
122.9 - 12000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
DKK1 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
24.58 - 2400 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$760
DKK1 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$715
DKK1 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$610
DKK1 ELISA Kit
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Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$585
DKK1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$585
DKK1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
46.9 - 3000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$624
DKK1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
DKK1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
46.9 - 3000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum
1 Plate/$699
DKK1 ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
15.625 - 1000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
DKK1 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
DKK1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
DKK1 ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Mouse
15.625 - 1000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
DKK1 ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
3.125 - 200 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
DKK1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
DKK1 ELISA Kit
Select
Sandwich
96-Well Microplate
Rat
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
DKK1 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
DKK1 ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
DKK1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$624
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).