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DIABLO / SMAC
diablo, IAP-binding mitochondrial protein
Second mitochondria-derived activator of caspase (SMAC) has been implicated in the activation of apoptosis in response to cell stress. SMAC promotes CASP9 activation by binding to IAPs and removing their inhibitory activity. The inhibitor of apoptosis proteins (IAPs) regulate programmed cell death by inhibiting members of the caspase family of enzymes. Smac/DIABLO is a mitochondrial protein that is released along with cytochrome c during apoptosis and activates cytochrome c/Apaf-1/caspase-9 pathway. Smac is an antagonist of the X-linked inhibitor of apoptosis (XIAP) - the most potent caspase inhibitor of all known inhibitor of apoptosis-family members. Smac promotes apoptosis by eliminating the inhibitory effect of inhibitor-of-apoptosis (IAPs) through physical interactions.
| Gene Name: | diablo, IAP-binding mitochondrial protein |
| Family/Subfamily: | Apoptosis , Not assigned-Apoptosis |
| Synonyms: | DIABLO, DFNA64, DIABLO-S, Diablo homolog, mitochondrial, SMAC3, Mitochondrial Smac protein, SMAC |
| Target Sequences: | NM_019887 NP_063940.1 Q9NR28 |
Publications (4)
1
Fundamental role of the Rip2/caspase-1 pathway in hypoxia and ischemia-induced neuronal cell death. Zhang WH, Wang X, Narayanan M, Zhang Y, Huo C, Reed JC, Friedlander RM. Proceedings of the National Academy of Sciences of the United States of America. 2003 100:16012-7. (ICC, WB; Mouse)
[PubMed:14663141]
[PMC:PMC307684]
2
Identification of tumorsphere- and tumor-initiating cells in HER2/Neu-induced mammary tumors. Liu JC, Deng T, Lehal RS, Kim J, Zacksenhaus E. Cancer research. 2007 67:8671-81.
[PubMed:17875707]
3
Inhibitors of cytochrome c release with therapeutic potential for Huntington's disease. Wang X, Zhu S, Pei Z, Drozda M, Stavrovskaya IG, Del Signore SJ, Cormier K, Shimony EM, Wang H, Ferrante RJ, Kristal BS, Friedlander RM. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008 28:9473-85.
[PubMed:18799679]
[PMC:PMC2632939]
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Antibodies
(52)
Type
Primary
(52)
Target
DIABLO / SMAC
(52)
Reactivity
Human
(52)
Mouse
(20)
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(15)
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(3)
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(3)
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(3)
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(3)
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(1)
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(3)
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(1)
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(3)
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(22)
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(1)
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(10)
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(42)
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(20)
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(3)
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(10)
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(13)
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(1)
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rabbit
(44)
mouse
(8)
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(4)
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(32)
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(1)
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(1)
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(1)
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(2)
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monoclonal mc
(9)
polyclonal pc
(43)
Clone
001
(1)
78-1-118
(1)
79-1-83
(1)
AT19F2
(1)
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(3)
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(2)
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(2)
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(4)
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(45)
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(6)
aa1-55
(2)
aa199-212
(2)
aa225-239
(1)
aa56-239
(1)
Publications
No
(52)
DIABLO / SMAC Mouse anti-Human Monoclonal (79-1-83) Antibody
Human, Monkey
IHC, IHC-P, WB
Unconjugated
50 µg/$460
DIABLO / SMAC Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, IP, WB
Unconjugated
0.05 mg/$460
DIABLO / SMAC Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, IP, WB
Unconjugated
0.1 mg/$460
DIABLO / SMAC Mouse anti-Human Monoclonal (aa1-55) (78-1-118) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
0.2 ml/$460
DIABLO / SMAC Mouse anti-Human Monoclonal Antibody
Human
ELISA, ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$702
DIABLO / SMAC Rabbit anti-Human Polyclonal Antibody
Human
ELISA, ICC, IF, WB
Unconjugated
100 µl/$412
DIABLO / SMAC Rabbit anti-Human Monoclonal (Preservative Free) (001) Antibody
Human
IP
Unconjugated, Preservative Free
100 µl/$412
DIABLO / SMAC Rabbit anti-Human Polyclonal (aa56-239) Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
DIABLO / SMAC Rabbit anti-Human Polyclonal (aa199-212) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µg/$460
DIABLO / SMAC Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$575
DIABLO / SMAC Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
DIABLO / SMAC Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$331
DIABLO / SMAC Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$546
DIABLO / SMAC Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
DIABLO / SMAC Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
DIABLO / SMAC Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Gerbil, Human
IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50 µl/$386
DIABLO / SMAC Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
DIABLO / SMAC Mouse anti-Human Monoclonal Antibody
Human
ICC, IF
Unconjugated
100 µl/$412
DIABLO / SMAC Rabbit anti-Human Polyclonal Antibody
Human
IHC, IP, WB
Unconjugated
50 µl/$393
DIABLO / SMAC Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Gerbil, Human
IHC, IP, WB
Unconjugated
50 µl/$393
DIABLO / SMAC Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Gerbil, Human
IHC, IP, WB
Unconjugated
50 µl/$393
DIABLO / SMAC Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IP, WB
Unconjugated
100 µl/$567
DIABLO / SMAC Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
100 µg/$522
DIABLO / SMAC Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
50 µl/$356; 100 µl/$461
DIABLO / SMAC Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IP, WB
Unconjugated
100 µl/$412
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product results
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