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CXCR4
chemokine (C-X-C motif) receptor 4
Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.
| Gene Name: | chemokine (C-X-C motif) receptor 4 |
| Family/Subfamily: | GPCR , Chemokine |
| Synonyms: | CXCR4, CD184, CD184 antigen, Cmkar4, Cxc chemokine receptor 4, CXCR-4, CXC-R4, D2S201E, FB22, Fusin, HM89, LCR1, NPY3R, NPYRL, NPYY3R, Npyy3, HSY3RR, SDF-1 receptor, WHIM, C-x-c chemokine receptor 4, LESTR, Neuropeptide Y receptor Y3, NPYR |
| Target Sequences: | NM_003467 NP_003458.1 P61073 |
Publications (6)
1
Inhibition of G alpha i2 activation by G alpha i3 in CXCR3-mediated signaling. Thompson BD, Jin Y, Wu KH, Colvin RA, Luster AD, Birnbaumer L, Wu MX. The Journal of biological chemistry. 2007 282:9547-55.
[PubMed:17289675]
[PMC:PMC2366813]
Related Antibodies: LS-B1986.
2
VEGFR1/ CXCR4 positive progenitor cells modulate local inflammation and augment tissue perfusion by a SDF-1 dependent mechanism. Andrew Wragg, Jason A Mellad, Leilani E Beltran, Mikhail Konoplyannikov, Hong San, Sherry Boozer, Robert J. Deans, Anthony Mathur, Robert J Lederman, Jason C Kovacic, and Manfred Boehm. Journal of molecular medicine (Berlin, Germany). 2008 86:1221-32. (WB, Flo; Mouse, Rat)
[Full Text Article]
[PubMed:18690419]
[PMC:PMC2575081]
3
Complement receptor 2/CD21- human naive B cells contain mostly autoreactive unresponsive clones. Isnardi I, Ng YS, Menard L, Meyers G, Saadoun D, Srdanovic I, Samuels J, Berman J, Buckner JH, Cunningham-Rundles C, Meffre E. Blood. 2010 115:5026-36.
[PubMed:20231422]
[PMC:PMC3373152]
Related Antibodies: LS-B1986.
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(104)
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(6)
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(12)
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CXCR4
(128)
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Human
(103)
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(46)
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(32)
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(1)
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aa17-42
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(1)
Publications
No
(124)
Yes
(4)
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(1)
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(1)
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(9)
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(1)
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(8)
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293T Cells
(1)
E. coli
(4)
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(2)
Wheat Germ Extract
(2)
Purification
Purified
(4)
Supernatant
(1)
Neuroscience
CXCR4 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Chicken, Rabbit, Mouse, Rat, Hamster, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
CXCR4 Mouse anti-Human Monoclonal (12G5) Antibody
Human, Baboon, Chimpanzee, African green monkey, Cynomolgus monkey, Rhesus monkey, Sooty Mangabey
Flo, IF, IHC, IHC-Fr, IHC-P
Unconjugated
50 µg/$460
Neuroscience
Fast Shipping
CXCR4 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
Fast Shipping
CXCR4 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
CXCR4 Rabbit anti-Human Polyclonal (aa300-349) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$440
CXCR4 Goat anti-Mouse Polyclonal (aa14-40) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$515
CXCR4 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$545
CXCR4 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Rabbit, Mouse, Dog, Sheep, Bovine, Rat, Pig, Human, Monkey
IHC, IHC-P, WB
Unconjugated
50 µl/$460
CXCR4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
CXCR4 Rabbit anti-Human Polyclonal (aa328-338) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
WB
Unconjugated
0.1 mg/$386
CXCR4 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
CXCR4 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, Flo, ICC, IF, IHC, IP, WB
Unconjugated
0.1 mg/$460
CXCR4 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$832
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Sandwich
96-Well Strip Plate
Human
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
HEK 293 Cells
6His, N-terminus
42 kDa
200 µl/$283
CXCR4 Rat anti-Mouse Monoclonal (PE) (247506) Antibody
Mouse
Flo
PE Conjugated
100 Tests/$746
Fast Shipping
CXCR4 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Mouse, Dog, Sheep, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
CXCR4 Goat anti-Zebrafish Polyclonal (aa184-193) Antibody
Zebrafish
Peptide-ELISA
Unconjugated
100 µg/$401
CXCR4 Rabbit anti-Human Monoclonal Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
CXCR4 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$294; 100 µg/$360
CXCR4 Rabbit anti-Human Polyclonal (aa18-33) Antibody
Dog, Sheep, Bovine, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$723
CXCR4 Rabbit anti-Human Polyclonal Antibody
Rat, Human
Flo, IHC, IHC-P, WB
Unconjugated
50 µl/$460
CXCR4 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$424
CXCR4 Rabbit anti-Human Polyclonal (pSer339) Antibody
Mouse, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
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