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CTTN / Cortactin
cortactin
CTTN / Cortactin is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.
| Gene Name: | cortactin |
| Synonyms: | CTTN, Cortactin, EMS1, Oncogene EMS1, Amplaxin, Src substrate cortactin |
| Target Sequences: | NM_005231 NP_005222.2 Q14247 |
Publications (2)
1
Overexpression and Tyr421-phosphorylation of cortactin is induced by three-dimensional spheroid culturing and contributes to migration and invasion of pancreatic ductal adenocarcinoma (PDAC) cells. Stock K, Borrink R, Mikesch JH, Hansmeier A, Rehkämper J, Trautmann M, Wardelmann E, Hartmann W, Sperveslage J, Steinestel K. Cancer cell international. 2019 March;19:77. [Full Text Article]
[PubMed:30976201]
[PMC:PMC6441202]
2
The Pathogenic Effect of Cortactin Tyrosine Phosphorylation in Cutaneous Squamous Cell Carcinoma. Zhu L#, Cho E#, Zhao G, Roh MR, Zheng Z. In Vivo. 2019 March-Apri;33:393-400. [Full Text Article]
[PubMed:30804117]
[PMC:PMC6506328]
Related Antibodies: LS-C353975, LS-C381441.
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CTTN / Cortactin Rabbit anti-Human Polyclonal (pTyr421) Antibody
Mouse, Human
IHC-P, WB
Unconjugated
30 µl/$263; 50 µl/$279; 100 µl/$315; 200 µl/$379
CTTN / Cortactin Rabbit anti-Human Polyclonal (pTyr466) Antibody
Mouse, Human
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
30 µl/$263; 50 µl/$279; 100 µl/$315; 200 µl/$379
CTTN / Cortactin Rabbit anti-Human Polyclonal (410-490 aa) Antibody
Mouse, Rat, Human, Monkey
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CTTN / Cortactin Rabbit anti-Human Polyclonal (aa388-437) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
CTTN / Cortactin Rabbit anti-Human Polyclonal (pTyr421) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$328; 100 µl/$419
CTTN / Cortactin Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
30 µl/$255; 50 µl/$271; 100 µl/$299; 200 µl/$351
CTTN / Cortactin Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CTTN / Cortactin Mouse anti-Human Monoclonal (4C6) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µl/$459
CTTN / Cortactin Rabbit anti-Human Polyclonal (aa450-500) Antibody
Human
IHC, IHC-P
Unconjugated
50 µl/$460
CTTN / Cortactin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, Flo, ICC, IHC-Fr, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
CTTN / Cortactin Rabbit anti-Human Polyclonal (aa450-500) Antibody
Human
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
CTTN / Cortactin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, IF, IHC, IP, WB
Unconjugated
100 µg/$331
CTTN / Cortactin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Flo, IF, IHC-P, WB
Unconjugated
100 µg/$575
CTTN / Cortactin Rabbit anti-Human Polyclonal (Acetyl-Lys235) Antibody
Chicken, Mouse, Rat, Human
WB
Unconjugated
30 µl/$276; 50 µl/$296; 100 µl/$341; 200 µl/$421
CTTN / Cortactin Rabbit anti-Human Polyclonal (pTyr466) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CTTN / Cortactin Rabbit anti-Human Polyclonal (410-490 aa) Antibody
Mouse, Rat, Human, Monkey
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CTTN / Cortactin Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, IHC-P, WB
Unconjugated
100 µl/$412
CTTN / Cortactin Rabbit anti-Human Polyclonal (aa110-159) (Biotin) Antibody
Chicken, Zebrafish, Pig, Horse, Bat, Rat, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey, Gibbon, Orangutan, Chimpanzee
WB
Biotin Conjugated
100 µl/$469
CTTN / Cortactin Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µl/$688
CTTN / Cortactin Rabbit anti-Mouse Polyclonal (pTyr466) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
CTTN / Cortactin Rabbit anti-Mouse Polyclonal (aa441-490) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
CTTN / Cortactin Mouse anti-Human Monoclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
CTTN / Cortactin Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
CTTN / Cortactin Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Human
IHC, IHC-P, IP, WB
Unconjugated
30 µl/$255; 50 µl/$271; 100 µl/$299; 200 µl/$351
CTTN / Cortactin Rabbit anti-Human Polyclonal (pTyr421) Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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