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CTNNB1 / Beta Catenin

catenin (cadherin-associated protein), beta 1, 88kDa

Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML.

Gene Name:	catenin (cadherin-associated protein), beta 1, 88kDa
Family/Subfamily:	Catenin , not assigned-Catenin
Synonyms:	CTNNB1, Beta-catenin, Catenin beta-1, CTNNB, Beta Catenin
Target Sequences:	NM_001904 NP_001895.1 P35222

Publications (7)

Wnt pathway-related gene expression during malignant progression in ulcerative colitis. van Dekken H, Wink JC, Vissers KJ, Franken PF, Ruud Schouten W, J Hop WC, Kuipers EJ, Fodde R, Janneke van der Woude C. Acta histochemica. 2007 109:266-72. (IHC) [PubMed:17445872]

Pro-metastatic intracellular signaling of the elaidic trans fatty acid. Fujii K, Luo Y, Fujiwara-Tani R, Kishi S, He S, Yang S, Sasaki T, Ohmori H, Kuniyasu H. International journal of oncology. 2017 50:85-92. (WB; Human) [Full Text Article] [PubMed:27959384]

Nitric Oxide Mediates Crosstalk between Interleukin 1ß and WNT Signaling in Primary Human Chondrocytes by Reducing DKK1 and FRZB Expression. Zhong L, Schivo S, Huang X, Leijten J, Karperien M, Post JN. International journal of molecular sciences. 2017 November;18:pii: E2491. (Human) [Full Text Article] [PubMed:29165387] [PMC:PMC5713457] Related Antibodies: LS-C203657.

Inhibition of Stress-Induced Viral Promoters by a Bovine Herpesvirus 1 Non-Coding RNA and the Cellular Transcription Factor, ß-Catenin. Jing Zhao, Nishani Wijesekera, Clinton Jones. International journal of molecular sciences. 2021 January;22: [Full Text Article] [PubMed:33430186] [PMC:PMC7825607] Related Antibodies: LS-C21245.

Bioengineered Tooth Buds Exhibit Features of Natural Tooth Buds. E E Smith, S Angstadt, N Monteiro, W Zhang, A Khademhosseini, P C Yelick. Journal of dairy science. 2018 September;97:1144-1151. [Full Text Article] [PubMed:29879370] [PMC:PMC6169029] Related Antibodies: LS-C172582.

An ARC-Regulated IL1ß/Cox-2/PGE2/ß-Catenin/ARC Circuit Controls Leukemia-Microenvironment Interactions and Confers Drug Resistance in AML. Bing Z Carter, Po Yee Mak, Xiangmeng Wang, Wenjing Tao, Vivian Ruvolo, Duncan Mak, Hong Mu, Jared K Burks, Michael Andreeff. Cancer research. 2019 Mar;79:1165-1177. [Full Text Article] [PubMed:30674535] [PMC:PMC6420856] Related Antibodies: LS-B4123.

Herpes simplex virus 1 regulates ß-catenin expression in TG neurons during the latency-reactivation cycle. Kelly S Harrison, Liqian Zhu, Prasanth Thunuguntla, Clinton Jones. PloS one. 2020 Mar;15:e0230870. [Full Text Article] [PubMed:32226020] [PMC:PMC7105109]

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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