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CTLA4 / CD152

cytotoxic T-lymphocyte-associated protein 4

CTLA4 / CD152 is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.

Gene Name: cytotoxic T-lymphocyte-associated protein 4
Synonyms: CTLA4, CD152, CELIAC3, CD152 antigen, CTLA-4, Celiac disease 3, IDDM12, GRD4, GSE, CD152 isoform
Target Sequences: NM_005214 NP_005205.2 P16410

Publications (6)

1
Phenotyping of Leukocytes and Leukocyte-Derived Extracellular Vesicles. Pugholm LH, Bæk R, Søndergaard EK, Revenfeld AL, Jørgensen MM, Varming K. Journal of immunology research. 2016 2016:6391264. (Flo; Human) [Full Text Article] [PubMed:27195303] [PMC:PMC4852366] Related Antibodies: LS-C134750.
2
Progression of benign prostatic hyperplasia is associated with pro-inflammatory mediators and chronic activation of prostate-infiltrating lymphocytes. Norström MM, Rådestad E, Sundberg B, Mattsson J, Henningsohn L, Levitsky V, Uhlin M. Oncotarget. 2016 7:23581-93. (Flo, ELISA; Human) [Full Text Article] [PubMed:26993768] [PMC:PMC5029649]
3
The Spectrum of Mild to Severe Psoriasis Vulgaris Is Defined by a Common Activation of IL-17 Pathway Genes, but with Key Differences in Immune Regulatory Genes. Kim J, Bissonnette R, Lee J, Correa da Rosa J, Suárez-Fariñas M, Lowes MA, Krueger JG. The Journal of investigative dermatology. 2016 November;136:2173-2182. (Human) [Full Text Article] [PubMed:27185339] Related Antibodies: LS-C35849.
4
Individualization of Hematopoietic Stem Cell Transplantation Using Alpha/Beta T-Cell Depletion. Emelie Rådestad, Mikael Sundin, Johan Törlén, Sarah Thunberg, Björn Önfelt, Per Ljungman, Emma Watz, Jonas Mattsson, Michael Uhlin. Frontiers in immunology. 2019 February;10:189. [Full Text Article] [PubMed:30804948] [PMC:PMC6378311]
5
Immunological function of Langerhans cells in HIV infection. Takamitsu Matsuzawa, Youichi Ogawa, Kohji Moriishi, Shinji Shimada, Tatsuyoshi Kawamura. Journal of dermatological science. 2017 Aug;87:159-167. [Full Text Article] [PubMed:28433429]
6
Transfer learning between preclinical models and human tumors identifies a conserved NK cell activation signature in anti-CTLA-4 responsive tumors. Emily F Davis-Marcisak # , Allison A Fitzgerald #, Michael D Kessler, Ludmila Danilova, Elizabeth M Jaffee, Neeha Zaidi, Louis M Weiner, Elana J Fertig. Genome medicine. 2021 Aug;13:129. [Full Text Article] [PubMed:34376232] [PMC:PMC8356429] Related Antibodies: LS-C193047.
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ELISA Kits (22)
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Sandwich (18)
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CTLA4 / CD152 (22)
Human (6)
Mouse (8)
Rat (1)
Chicken (1)
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Guinea pig (1)
Pig (1)
Porcine (1)
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12 x 8-Well Microstrips (3)
96-Well Microplate (4)
96-Well Strip Plate (15)
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Cell Culture Supernatants (3)
Cell Lysates (1)
Plasma (15)
Serum (15)
Tissue Homogenates (5)
CTLA4 / CD152 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$798
CTLA4 / CD152 ELISA Kit
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Sandwich
96-Well Strip Plate
Dog
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
CTLA4 / CD152 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$699
CTLA4 / CD152 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
1.646 - 400 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$760
CTLA4 / CD152 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$585
CTLA4 / CD152 ELISA Kit
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Custom
96-Well Strip Plate
Pig
Colorimetric - 450nm (TMB)
1 Plate/$669
CTLA4 / CD152 ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
CTLA4 / CD152 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
CTLA4 / CD152 ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
CTLA4 / CD152 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$624
CTLA4 / CD152 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CTLA4 / CD152 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CTLA4 / CD152 ELISA Kit
Select
Sandwich
12 x 8-Well Microstrips
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
CTLA4 / CD152 ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
CTLA4 / CD152 ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Mouse
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
CTLA4 / CD152 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Guinea pig
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
CTLA4 / CD152 ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
CTLA4 / CD152 ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
CTLA4 / CD152 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Sheep
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$691
CTLA4 / CD152 ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
CTLA4 / CD152 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$822
CTLA4 / CD152 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$822
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).