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CSPG4 / NG2

chondroitin sulfate proteoglycan 4

Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades.

Gene Name: chondroitin sulfate proteoglycan 4
Synonyms: CSPG4, MCSP, MEL-CSPG, MSK16, NG2, HMW-MAA, MCSPG
Target Sequences: NM_001897 NP_001888.2 Q6UVK1

Publications (2)

1
Decellularized extracellular matrix scaffolds identify full-length collagen VI as a driver of breast cancer cell invasion in obesity and metastasis. Andrew L Wishart, Sydney J Conner, Justinne R Guarin, Jackson P Fatherree, Yifan Peng, Rachel A McGinn, Rebecca Crews, Stephen P Naber, Martin Hunter, Andrew S Greenberg, Madeleine J Oudin. Science advances. 2020 October;6: [Full Text Article] [PubMed:33087348] [PMC:PMC7577726] Related Antibodies: LS-C22113.
2
Stem Cells from Human Exfoliated Deciduous Teeth (SHEDs) and Dental Pulp Stem Cells (DPSCs) Display a Similar Profile with Pericytes. Shao Yue Zhu , Chang Yong Yuan, Yi Fan Lin, Hao Liu, Yan Qi Yang, Hai Ming Wong, Cheng Fei Zhang, Peng Lai Wang, Min Gu. Stem cells international. 2021 Jul;2021:8859902. [Full Text Article] [PubMed:34349804] [PMC:PMC8328701] Related Antibodies: LS-C72310.

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ELISA Kits (8)
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CSPG4 / NG2 (8)
Human (6)
Mouse (1)
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12 x 8-Well Microstrips (1)
96-Well Microplate (2)
96-Well Strip Plate (5)
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Cell Lysates (2)
Plasma (6)
Serum (6)
Tissue Homogenates (3)
CSPG4 / NG2 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
CSPG4 / NG2 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CSPG4 / NG2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$798
CSPG4 / NG2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
CSPG4 / NG2 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
CSPG4 / NG2 ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
31.25 - 2000 pg/ml
Chemiluminescent
Cell Lysates
1 Plate/$656
CSPG4 / NG2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CSPG4 / NG2 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
1.23 - 300 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$559
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).