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CSPG4 / NG2
chondroitin sulfate proteoglycan 4
Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades.
| Gene Name: | chondroitin sulfate proteoglycan 4 |
| Synonyms: | CSPG4, MCSP, MEL-CSPG, MSK16, NG2, HMW-MAA, MCSPG |
| Target Sequences: | NM_001897 NP_001888.2 Q6UVK1 |
Publications (2)
1
Decellularized extracellular matrix scaffolds identify full-length collagen VI as a driver of breast cancer cell invasion in obesity and metastasis. Andrew L Wishart, Sydney J Conner, Justinne R Guarin, Jackson P Fatherree, Yifan Peng, Rachel A McGinn, Rebecca Crews, Stephen P Naber, Martin Hunter, Andrew S Greenberg, Madeleine J Oudin. Science advances. 2020 October;6: [Full Text Article]
[PubMed:33087348]
[PMC:PMC7577726]
Related Antibodies: LS-C22113.
2
Stem Cells from Human Exfoliated Deciduous Teeth (SHEDs) and Dental Pulp Stem Cells (DPSCs) Display a Similar Profile with Pericytes. Shao Yue Zhu , Chang Yong Yuan, Yi Fan Lin, Hao Liu, Yan Qi Yang, Hai Ming Wong, Cheng Fei Zhang, Peng Lai Wang, Min Gu. Stem cells international. 2021 Jul;2021:8859902. [Full Text Article]
[PubMed:34349804]
[PMC:PMC8328701]
Related Antibodies: LS-C72310.
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CSPG4 / NG2 Mouse anti-Human Monoclonal (LHM2) Antibody
Human
Flo, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
100 µg/$649
CSPG4 / NG2 Mouse anti-Human Monoclonal (Azide-free) Antibody
Human
Flo, Func, IF, IP
Unconjugated, Azide-free
100 µg/$984
Neuroscience
CSPG4 / NG2 Mouse anti-Human Monoclonal (aa559-776) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
Neuroscience
CSPG4 / NG2 Rabbit anti-Human Polyclonal Antibody
Human
IHC-P, WB
Unconjugated
50 µl/$460
CSPG4 / NG2 Rabbit anti-Rat Polyclonal Antibody
Mouse, Rat, Human, Monkey
ELISA, ICC, IHC, IHC-Fr, IP, WB
Unconjugated
100 µg/$951
CSPG4 / NG2 Mouse anti-Human Monoclonal (9.9.27) Antibody
Human
Flo, IF, IP
Unconjugated
100 µg/$867
CSPG4 / NG2 Mouse anti-Rat Monoclonal (aa1592-2222) Antibody
Rat
IHC, WB
Unconjugated
200 µg/$947
CSPG4 / NG2 Rabbit anti-Mouse Polyclonal (aa2080-2130) Antibody
Mouse
WB
Unconjugated
500 µg/$393
E. coli
6His, N-terminus
25.1 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CSPG4 / NG2 Mouse anti-Rat Monoclonal (N-Terminus) Antibody
Rat
ELISA, IF, IP, WB
Unconjugated
100 µg/$786
CSPG4 / NG2 Mouse anti-Rat Monoclonal (Biotin) Antibody
Rat, Human
ELISA, IF, IHC, IP, WB
Biotin Conjugated
100 µl/$1,017
CSPG4 / NG2 Mouse anti-Rat Monoclonal (FITC) Antibody
Rat, Human
ELISA, IF, IHC, IP, WB
FITC Conjugated
100 µl/$1,017
CSPG4 / NG2 Mouse anti-Rat Monoclonal (APC) Antibody
Rat, Human
ELISA, IF, IHC, IP, WB
APC Conjugated
100 µl/$1,017
CSPG4 / NG2 Mouse anti-Rat Monoclonal (PE) Antibody
Rat, Human
ELISA, IF, IHC, IP, WB
PE Conjugated
100 µl/$1,017
CSPG4 / NG2 Mouse anti-Rat Monoclonal Antibody
Rat, Human
ELISA, IF, IHC, IHC-Fr, IP
Unconjugated
100 µg/$740
CSPG4 / NG2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
E. coli
His
34.8 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
CSPG4 / NG2 Mouse anti-Cat Monoclonal Antibody
Rat, Cat
ICC, IHC, IHC-Fr, IP, WB
Unconjugated
100 µl/$801
CSPG4 / NG2 Mouse anti-Human Monoclonal (aa2247-2308) (7G4E5) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µl/$459
CSPG4 / NG2 Rabbit anti-Rat Polyclonal (aa1919-2258) Antibody
Rat
WB
Unconjugated
100 µl/$312; 200 µl/$355; 500 µl/$500; 1 ml/$573; 2 ml/$780; 5 ml/$1,268
CSPG4 / NG2 Mouse anti-Human Monoclonal (7.1) Antibody
Human
Flo, ICC, IP, WB
Unconjugated
0.1 mg/$302
CSPG4 / NG2 Mouse anti-Human Monoclonal (PE) (7.1) Antibody
Human
Flo, ICC, IP, WB
PE Conjugated
100 Tests/$365
CSPG4 / NG2 Mouse anti-Cat Monoclonal Antibody
Cat
ICC, IHC, IHC-Fr, IP, WB
Unconjugated
100 µl/$860
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