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CREBBP / CREB Binding Protein

CREB binding protein

CREBBP / CREB Binding Protein is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene Name: CREB binding protein
Synonyms: CREBBP, CREB binding protein, CREB-binding protein, KAT3A, RSTS, Rubinstein-Taybi syndrome, RTS, CBP
Target Sequences: NM_004380 NP_004371.2 Q92793

Publications (1)

1
Alcohol exposure decreases CREB binding protein expression and histone acetylation in the developing cerebellum. Guo W, Crossey EL, Zhang L, Zucca S, George OL, Valenzuela CF, Zhao X. PloS one. 2011 6:e19351. (IHC-Fr; Rat) [Full Text Article] [PubMed:21655322] [PMC:PMC3104983]

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Antibodies (90)
ELISA Kits (13)
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CREBBP / CREB Binding Protein (110)
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rabbit (80)
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CREBBP / CREB Binding Protein Antibody - Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
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CREBBP / CREB Binding Protein Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Chicken, Bovine, Mouse, Dog, Rat, Pig, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
CREBBP / CREB Binding Protein Antibody - Anti-CREBBP antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
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CREBBP / CREB Binding Protein Rabbit anti-Human Polyclonal (aa2393-2442) Antibody
Mouse, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
CREBBP / CREB Binding Protein Antibody - Anti-CREBBP antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:25.
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CREBBP / CREB Binding Protein Mouse anti-Human Monoclonal (aa2071-2091) Antibody
Mouse, Rat, Human, Monkey
IF, IHC, IHC-P
Unconjugated
125 µl/$525
CREBBP / CREB Binding Protein Antibody - Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using CBP Antibody. The picture on the right is blocked with the synthesized peptide.
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CREBBP / CREB Binding Protein Rabbit anti-Human Polyclonal (aa1501-1550) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
CREBBP / CREB Binding Protein ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CREBBP / CREB Binding Protein Antibody - Immunohistochemistry of paraffin-embedded rat lung using CREBBP antibodyat dilution of 1:100 (40x lens).
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CREBBP / CREB Binding Protein Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
CREBBP / CREB Binding Protein Antibody - Western blot of Acetyl-CBP (K1535) antibody
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CREBBP / CREB Binding Protein Rabbit anti-Human Polyclonal (1480-1550 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CREBBP / CREB Binding Protein Antibody - Immunohistochemical analysis of CBP staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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CREBBP / CREB Binding Protein Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
CREBBP / CREB Binding Protein Antibody - Immunohistochemical analysis of CBP (AcK1535) staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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CREBBP / CREB Binding Protein Rabbit anti-Human Polyclonal (Acetyl-Lys1535) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$315
CREBBP / CREB Binding Protein Antibody - 1:100 staining human brain tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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CREBBP / CREB Binding Protein Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CREBBP / CREB Binding Protein Antibody - Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-CBP mAb.
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CREBBP / CREB Binding Protein Mouse anti-Human Monoclonal (CBP5I001) Antibody
Mouse, Human
DB, ICC, IF, IP, WB
Unconjugated
100 µg/$486
CREBBP / CREB Binding Protein Antibody - Peptide - + Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using CREB-BP antibody.
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CREBBP / CREB Binding Protein Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
CREBBP / CREB Binding Protein Antibody - 1:200 staining human Testis tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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CREBBP / CREB Binding Protein Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CREBBP / CREB Binding Protein Antibody - Western blot of HeLa cell lysate using CREB-BP Antibody
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CREBBP / CREB Binding Protein Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ICC, IF, IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
CREBBP / CREB Binding Protein Antibody - Western blot of HeLa cell lysate using CBP Antibody
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CREBBP / CREB Binding Protein Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IF, IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
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CREBBP / CREB Binding Protein Mouse anti-Human Monoclonal (Azide-free) Antibody
Mouse, Rat, Mink, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated, Azide-free
100 µl/$981
CREBBP / CREB Binding Protein Antibody - Western blot of CBP antibody
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CREBBP / CREB Binding Protein Rabbit anti-Human Polyclonal (1480-1550 aa) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CREBBP / CREB Binding Protein Antibody - Anti-CREBBP antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CREBBP / CREB Binding Protein Rabbit anti-Human Polyclonal (aa144-193) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
CREBBP / CREB Binding Protein Antibody - Immunohistochemistry image of paraffin-embedded human breast cancer at a dilution of 1:100
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CREBBP / CREB Binding Protein Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
CREBBP / CREB Binding Protein ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CREBBP / CREB Binding Protein ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CREBBP / CREB Binding Protein Protein - Recombinant CREB Binding Protein By SDS-PAGE
Select
E. coli
His
33.8 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
CREBBP / CREB Binding Protein Protein - Recombinant CREB Binding Protein By SDS-PAGE
Select
E. coli
His
25.4 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
CREBBP / CREB Binding Protein Antibody - Western blot of CBP (E1528) pAb in extracts from HT-29 cells treated with calyculin A 50ng.
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CREBBP / CREB Binding Protein Rabbit anti-Human Polyclonal (Glu1528) Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
50 µl/$321; 100 µl/$403
CREBBP / CREB Binding Protein Antibody - Immunofluorescence of monoclonal antibody to CREBBP on HeLa cell . [antibody concentration 10 ug/ml]
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CREBBP / CREB Binding Protein Mouse anti-Human Monoclonal (2H5) Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$423
Viewing 1-25 of 110 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).