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CLDN1 / Claudin 1
claudin 1
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391). CLDN1 acts as a coreceptor for HCV entry into hepatic cells.
| Gene Name: | claudin 1 |
| Family/Subfamily: | Claudin , not assigned-Claudin |
| Synonyms: | CLDN1, Claudin-1, Claudin 1, ILVASC, SEMP1, CLD1 |
| Target Sequences: | NM_021101 NP_066924.1 O95832 |
Publications (8)
1
Deeply located low-grade fibromyxoid sarcoma with FUS-CREB3L2 gene fusion in a 5-year-old boy with review of literature. Kurisaki-Arakawa A, Suehara Y, Arakawa A, Takagi T, Takahashi M, Mitani K, Kaneko K, Yao T, Saito T. Diagnostic pathology. 2014 9:163. (IHC; Human)
[Full Text Article]
[PubMed:25183312]
[PMC:PMC4167136]
Related Antibodies: LS-B6327.
2
Satellite cells maintain regenerative capacity but fail to repair disease-associated muscle damage in mice with Pompe disease. Schaaf GJ, van Gestel TJM, In 't Groen SLM, de Jong B, Boomaars B, Tarallo A, Cardone M, Parenti G, van der Ploeg AT, Pijnappel WWMP. Acta neuropathologica communications. 2018 November;6:119. [Full Text Article]
[PubMed:30404653]
[PMC:PMC6220463]
Related Antibodies: LS-C6142.
3
A Chinese Prescription Yu-Ping-Feng-San Administered in Remission Restores Bronchial Epithelial Barrier to Inhibit House Dust Mite-Induced Asthma Recurrence. Kaifan Bao, Weiyuan Yuan, Yijing Zhou, Yanyan Chen, Xuerui Yu, Xiaoyu Wang, Zhirong Jia, Xi Yu, Xiaotong Wang, Lu Yao, Siqi Wang, Yifan Xu, Yuheng Zhang, Jie Zheng, Min Hong. Frontiers in pharmacology. 2020 February;10:1698. [Full Text Article]
[PubMed:32076408]
[PMC:PMC7006455]
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CLDN1 / Claudin 1 Rabbit anti-Human Polyclonal (aa162-211) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
CLDN1 / Claudin 1 Mouse anti-Human Monoclonal (1C5-D9) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
CLDN1 / Claudin 1 Rabbit anti-Human Polyclonal (140-220 aa, C-terminal) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CLDN1 / Claudin 1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Dog, Rat, Human, Monkey
IHC, IHC-P, WB
Unconjugated
250 µl/$495
CLDN1 / Claudin 1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Dog, Rat, Human, Monkey
ELISA, IHC, IHC-P, WB
Unconjugated
125 µl/$495
Cancer
CLDN1 / Claudin 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC-P, WB
Unconjugated
50 µg/$460
Sandwich
96-Well Microplate
Human
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
CLDN1 / Claudin 1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Dog, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
100 µg/$763
CLDN1 / Claudin 1 Mouse anti-Human Monoclonal (C-Terminus) (2H10D10) Antibody
Mouse, Dog, Rat, Human
ELISA, IF, IHC, IHC-Fr, IP, WB
Unconjugated
100 µg/$786
CLDN1 / Claudin 1 Mouse anti-Human Monoclonal (Biotin) Antibody
Mouse, Dog, Rat, Human
ELISA, IF, IHC, IP, WB
Biotin Conjugated
100 µl/$1,017
CLDN1 / Claudin 1 Mouse anti-Human Monoclonal (FITC) Antibody
Mouse, Dog, Rat, Human
ELISA, IF, IHC, IP, WB
FITC Conjugated
100 µl/$1,017
CLDN1 / Claudin 1 Mouse anti-Human Monoclonal (APC) Antibody
Mouse, Dog, Rat, Human
ELISA, IF, IHC, IP, WB
APC Conjugated
100 µl/$1,017
CLDN1 / Claudin 1 Mouse anti-Human Monoclonal (PE) Antibody
Mouse, Dog, Rat, Human
ELISA, IF, IHC, IP, WB
PE Conjugated
100 µl/$1,017
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$730
Sandwich
96-Well Strip Plate
Rat
78.13 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$783
Sandwich
96-Well Microplate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$748
Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
293T Cells
Myc-DDK (Flag)
22.6 kDa
20 µg/$150
CLDN1 / Claudin 1 Rabbit anti-Human Polyclonal (aa40-82) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
CLDN1 / Claudin 1 Rabbit anti-Human Polyclonal (aa40-82) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
CLDN1 / Claudin 1 Rabbit anti-Human Polyclonal (aa162-211) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
CLDN1 / Claudin 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, ICC, IF, WB
Unconjugated
0.1 mg/$460
CLDN1 / Claudin 1 Mouse anti-Human Monoclonal (C-Terminus) (2H10D10) Antibody
Mouse, Dog, Rat, Human
ELISA, ICC, IF, IP, WB
Unconjugated
100 µg/$520
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