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CIRP / CIRBP
cold inducible RNA binding protein
Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor By similarity. Promotes assembly of stress granules (SGs), when overexpressed.
| Gene Name: | cold inducible RNA binding protein |
| Synonyms: | CIRBP, A18 hnRNP, A18HNRNP, CIRP |
| Target Sequences: | NM_001280 NP_001271.1 Q14011 |
Publications (3)
1
Extracellular CIRP decreases Siglec-G expression on B-1a cells skewing them towards a pro-inflammatory phenotype in sepsis. William Royster, Hui Jin, Ping Wang , Monowar Aziz. Molecular medicine (Cambridge, Mass.). 2021 May;27:55. [Full Text Article]
[PubMed:34058975]
[PMC:PMC8165807]
2
Extracellular CIRP activates STING to exacerbate hemorrhagic shock. Kehong Chen, Joaquin Cagliani, Monowar Aziz, Chuyi Tan, Max Brenner, Ping Wang. JCI insight. 2021 July;6:e143715. [Full Text Article]
[PubMed:34291735]
[PMC:PMC8410031]
3
Extracellular microRNA 130b-3p inhibits eCIRP-induced inflammation. Steven D Gurien, Monowar Aziz, Hui Jin, Haichao Wang, Mingzhu He, Yousef Al-Abed, Jeffrey M Nicastro, Gene F Coppa, Ping Wang. EMBO reports. 2020 Janurary;21:e48075. [Full Text Article]
[PubMed:31724825]
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CIRP / CIRBP Goat anti-Human Polyclonal (aa161-172) Antibody
Mouse, Dog, Rat, Hamster, Pig, Bat, Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
E. coli
6His, N-terminus
22.6 kDa
1 mg/$1,679; 100 µg/$598; 20 µg/$405
CIRP / CIRBP Mouse anti-Human Monoclonal (1C9) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$440
CIRP / CIRBP Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$730
CIRP / CIRBP Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$341
CIRP / CIRBP Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$287; 100 µl/$431
CIRP / CIRBP Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
CIRP / CIRBP Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Guinea pig, Human, Monkey, Chimpanzee, Orangutan
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
CIRP / CIRBP Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Guinea pig, Human, Monkey, Chimpanzee, Orangutan
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
CIRP / CIRBP Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Guinea pig, Human, Monkey, Chimpanzee, Orangutan
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
CIRP / CIRBP Mouse anti-Human Monoclonal (6E12D5) Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µl/$459
E. coli
His-T7
22.5 kDa
10 µg/$282; 50 µg/$447; 100 µg/$715; 200 µg/$892; 1 mg/$2,005; 500 µg/$1,543; 5 mg/$3,123; 2 mg/$2,192
CIRP / CIRBP Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
60 µl/$343; 120 µl/$427; 200 µl/$559
CIRP / CIRBP Mouse anti-Human Monoclonal (6E12B3) Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µl/$459
CIRP / CIRBP Rabbit anti-Human Polyclonal (aa145-172) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
CIRP / CIRBP Rabbit anti-Human Polyclonal (aa145-172) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
CIRP / CIRBP Rabbit anti-Human Polyclonal (aa145-172) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
CIRP / CIRBP Rabbit anti-Human Polyclonal (aa145-172) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
CIRP / CIRBP Rabbit anti-Human Polyclonal (aa145-172) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
CIRP / CIRBP Rabbit anti-Human Polyclonal (aa145-172) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
CIRP / CIRBP Rabbit anti-Human Polyclonal (aa145-172) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
CIRP / CIRBP Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
20 µl/$275; 100 µl/$389
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