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CD79A / CD79 Alpha
CD79a molecule, immunoglobulin-associated alpha
Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.
| Gene Name: | CD79a molecule, immunoglobulin-associated alpha |
| Synonyms: | CD79A, CD79a antigen, Ig-alpha, MB-1, MB-1 membrane glycoprotein, Surface IgM-associated protein, MB1 |
| Target Sequences: | NM_021601 NP_001774.1 P11912 |
Publications (8)
1
Immunopathogenesis of severe acute respiratory disease in Zaire ebolavirus-infected pigs. Nfon CK, Leung A, Smith G, Embury-Hyatt C, Kobinger G, Weingartl HM. PloS one. 2013 8:e61904. (IHC; Porcine)
[Full Text Article]
[PubMed:23626748]
[PMC:PMC3633953]
Related Antibodies: LS-B4504.
2
Negative feedback regulation of antigen receptors through calmodulin inhibition of E2A. Verma-Gaur J, Hauser J, Grundström T. Journal of immunology (Baltimore, Md. : 1950). 2012 188:6175-83. (WB; Mouse)
[Full Text Article]
[PubMed:22581853]
Related Antibodies: LS-C44953.
3
Association of renal tubular hyaline droplets with lymphoma in CD-1 mice. Decker JH, Dochterman LW, Niquette AL, Brej M. Toxicologic pathology. 2012 40:651-5. (WB; Human)
[Full Text Article]
[PubMed:22395792]
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Antibodies
(137)
Proteins
(9)
Type
Over-Expression Lysate
(2)
Primary
(137)
Recombinant
(7)
Target
CD79A / CD79 Alpha
(146)
Reactivity
Human
(122)
Mouse
(32)
Rat
(16)
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(13)
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(3)
Chicken
(8)
Chimpanzee
(6)
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(2)
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(6)
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(8)
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(2)
Monkey
(8)
Non-Human Primates
(3)
Opossum
(3)
Pig
(7)
Porcine
(6)
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(8)
Application
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(42)
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(9)
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(49)
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(76)
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rabbit
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mouse
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(40)
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(33)
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monoclonal mc
(72)
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(61)
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(16)
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(73)
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aa202-216
(17)
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110-190 aa, Internal
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aa121-226
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aa154-203
(1)
sequence AA 200+ of human CD79a protein
(1)
Publications
No
(143)
Yes
(3)
Tag
6His, C-terminus
(1)
6His, N-terminus
(1)
DDK (Flag)-His, C-terminus
(1)
Fc
(1)
GST, N-terminus
(1)
His-T7
(2)
Myc-DDK (Flag)
(2)
Species
Human
(6)
Mouse
(2)
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293T Cells
(1)
E. coli
(3)
HEK 293 Cells
(2)
Human
(1)
Human Cells
(1)
Wheat Germ Extract
(1)
Purification
Purified
(2)
Low Endotoxin Level
Low endotoxin level
(2)
CD79A / CD79 Alpha Mouse anti-Human Monoclonal Antibody
Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Pig, Horse, Human, Monkey
Flo, IHC, IHC-Fr, IHC-P, WB
Unconjugated
0.25 ml/$605
CD79A / CD79 Alpha Mouse anti-Human Monoclonal (HM57) Antibody
Chicken, Bovine, Rabbit, Mouse, Guinea pig, Porcine, Rat, Opossum, Equine, Human
Flo, IHC, IHC-Fr, IHC-P
Unconjugated
0.05 mg/$460
CD79A / CD79 Alpha Mouse anti-Human Monoclonal (PE) (HM57) Antibody
Chicken, Bovine, Rabbit, Mouse, Guinea pig, Porcine, Rat, Opossum, Equine, Human
Flo, IHC-Fr, IHC-P
PE Conjugated
100 Tests/$365
CD79A / CD79 Alpha Mouse anti-Human Monoclonal (aa208-222) (HM47) Antibody
Chicken, Bovine, Canine, Porcine, Rat, Equine, Rabbit, Mouse, Guinea pig, Non-Human Primates, Human
Flo, IHC, IHC-P, IP, WB
Unconjugated
0.1 mg/$309
CD79A / CD79 Alpha Mouse anti-Human Monoclonal (aa208-222) (PE) (HM47) Antibody
Chicken, Bovine, Canine, Porcine, Rat, Equine, Rabbit, Mouse, Guinea pig, Non-Human Primates, Human
Flo, IHC-P, IP, WB
PE Conjugated
100 Tests/$365
CD79A / CD79 Alpha Mouse anti-Human Monoclonal (ZL7-4) Antibody
Human
Flo
Unconjugated
100 µg/$411
CD79A / CD79 Alpha Mouse anti-Human Monoclonal (Biotin) (ZL7-4) Antibody
Human
Flo
Biotin Conjugated
100 µg/$446
CD79A / CD79 Alpha Mouse anti-Human Monoclonal (RPE) (ZL7-4) Antibody
Human
Flo
RPE Conjugated
120 Tests/$511
CD79A / CD79 Alpha Mouse anti-Human Monoclonal (Extracellular Domain) (APC) (1D4B) Antibody
Human
Flo
APC Conjugated
100 Tests/$846
CD79A / CD79 Alpha Mouse anti-Human Monoclonal (Extracellular Domain) (PE) (1D4B) Antibody
Human
Flo
PE Conjugated
100 Tests/$746
CD79A / CD79 Alpha Mouse anti-Human Monoclonal (APC) (HM47) Antibody
Chicken, Bovine, Canine, Porcine, Rat, Equine, Rabbit, Mouse, Guinea pig, Non-Human Primates, Human
Flo, IHC-P, IP, WB
APC Conjugated
100 Tests/$365
CD79A / CD79 Alpha Rabbit anti-Human Monoclonal (sequence AA 200+ of human CD79a protein) (SP18) Antibody
Human
Flo, IHC, IHC-P
Unconjugated
250 µl/$460
Cancer Pathology
Cancer
CD79A / CD79 Alpha Rabbit anti-Human Recombinant Monoclonal (aa202-216) (IGA/1790R) Antibody
Human
Flo, IF, IHC-P, WB
Unconjugated
100 µg/$525
CD79A / CD79 Alpha Mouse anti-Human Monoclonal (aa202-216) (JCB117 + HM47/A9) Antibody
Mouse, Rat, Human
Flo, IF, IHC-P, WB
Unconjugated
50 µg/$460
CD79A / CD79 Alpha Mouse anti-Human Monoclonal (Cytoplasmic Domain) (FITC) (HM57) Antibody
Human
Flo
FITC Conjugated
0.1 mg/$432
Cancer Pathology
Cancer
CD79A / CD79 Alpha Rabbit anti-Human Recombinant Monoclonal (aa202-216) (IGA/1688R) Antibody
Human
Flo, IF, IHC-P, WB
Unconjugated
100 µg/$525
CD79A / CD79 Alpha Mouse anti-Human Monoclonal (aa202-216) (JCB117) Antibody
Human
ELISA, Flo, IF, IHC, IHC-P, IP, WB
Unconjugated
20 µg/$371; 100 µg/$574
CD79A / CD79 Alpha Mouse anti-Human Monoclonal (aa202-216) (Ready-to-Use) (JCB117) Antibody
Human
ELISA, Flo, IF, IHC, IHC-P, IP, WB
Unconjugated, Ready-to-Use
7 ml/$574
CD79A / CD79 Alpha Mouse anti-Human Monoclonal (aa202-216) (Azide-free, BSA-free) (JCB117) Antibody
Human
ELISA, Flo, IF, IHC, IHC-P, IP, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
CD79A / CD79 Alpha Rabbit anti-Human Polyclonal (aa122-149) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
CD79A / CD79 Alpha Mouse anti-Human Monoclonal (ZL7-4) Antibody
Human
ELISA, Flo, IHC-P, IP
Unconjugated
0.05 mg/$460
CD79A / CD79 Alpha Mouse anti-Human Monoclonal (aa202-216) (HM47/A9) Antibody
Mouse, Rat, Human
Flo, IF, IHC, IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
CD79A / CD79 Alpha Mouse anti-Human Monoclonal Antibody
Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Pig, Horse, Human, Monkey
Flo, IHC, IHC-Fr, IHC-P
Unconjugated
100 µg/$562; 200 µg/$794
CD79A / CD79 Alpha Mouse anti-Human Monoclonal (Azide-free) (ZL7-4) Antibody
Human
Flo
Unconjugated, Azide-free
100 µg/$411
CD79A / CD79 Alpha Rabbit anti-Mouse Polyclonal (aa30-193) Antibody
Mouse
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
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