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CD59
CD59 molecule, complement regulatory protein
CD59 is a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.
| Gene Name: | CD59 molecule, complement regulatory protein |
| Synonyms: | CD59, 16.3A5, 1F5, 1F5 antigen, CD59 glycoprotein, EL32, EJ16, G344, HRF-20, MAC-IP, MACIF, Ly-6-like protein, MEM43, MIRL, MEM43 antigen, MIN2, MIN3, MSK21, p18-20, Protectin, MAC-inhibitory protein, MIC11, T cell-activating protein, CD59 antigen, EJ30, HRF20, Human leukocyte antigen MIC11, Lymphocytic antigen CD59/MEM43, MIN1 |
| Target Sequences: | NM_000611 NP_000602.1 P13987 |
Publications (4)
1
Longitudinally extensive NMO spinal cord pathology produced by passive transfer of NMO-IgG in mice lacking complement inhibitor CD59. Zhang H, Verkman AS. Journal of autoimmunity. 2014 53:67-77. (WB; Mouse)
[Full Text Article]
[PubMed:24698947]
[PMC:PMC4162764]
Related Antibodies: LS-C210252.
2
A 4-gene signature predicts survival of patients with resected adenocarcinoma of the esophagus, junction, and gastric cardia. Christopher J Peters, Jonathan R E Rees, Richard H Hardwick, James S Hardwick, Sarah L Vowler, Chin-Ann J Ong, Chunsheng Zhang, Vicki Save, Maria O'Donovan, Doris Rassl, Derek Alderson, Carlos Caldas, Rebecca C Fitzgerald, Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Study Group. Gastroenterology. 2010 December;139:1995-2004.e15. [Full Text Article]
[PubMed:20621683]
Related Antibodies: LS-B1852.
3
CD55 upregulation in astrocytes by statins as potential therapy for AQP4-IgG seropositive neuromyelitis optica. Lukmanee Tradtrantip, Tianjiao Duan, Michael R Yeaman, Alan S Verkman. Journal of neuroinflammation. 2019 March;16:57. [Full Text Article]
[PubMed:30851734]
[PMC:PMC6408857]
Related Antibodies: LS-C209613.
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Antibodies
(196)
Type
Primary
(196)
Target
CD59
(196)
Reactivity
Human
(143)
Mouse
(17)
Rat
(25)
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(1)
Crab-eating macaque
(1)
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(1)
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(9)
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(10)
Porcine
(1)
Rabbit
(11)
Rhesus monkey
(1)
Application
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(55)
IHC-Fr
(9)
IHC-P
(32)
WB
(106)
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(95)
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(32)
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(9)
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(1)
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(27)
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(19)
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(97)
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(3)
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(50)
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(16)
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(23)
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(105)
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(89)
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(16)
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(1)
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(6)
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(14)
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(10)
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(19)
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(6)
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(2)
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(2)
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(6)
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(6)
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(26)
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(4)
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(88)
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aa25-104
(11)
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(10)
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(8)
aa22-96
(8)
aa23-105
(8)
aa26-98
(8)
aa209-469
(2)
41-90 aa, Internal
(1)
Amino Acid: 31-111
(1)
aa29-102
(1)
Publications
No
(193)
Yes
(3)
Cancer
CD59 Mouse anti-Human Monoclonal (MEM-43) Antibody
Human
Flo, IHC, IHC-P, IP
Unconjugated
0.05 mg/$460
Cancer
CD59 Mouse anti-Human Monoclonal (MEM-43/5) Antibody
Mouse, Human
Flo, IHC, IHC-P, IP, WB
Unconjugated
0.05 mg/$460
CD59 Mouse anti-Human Monoclonal (1F5) Antibody
Human
Flo, IHC, IHC-P
Unconjugated
50 µg/$460
CD59 Mouse anti-Human Monoclonal (p282(H19)) Antibody
Human, Monkey, Baboon
Flo, IHC, IHC-P
Unconjugated
50 µg/$460
CD59 Mouse anti-Human Monoclonal (8D2B8) Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
100 µl/$459
CD59 Mouse anti-Human Monoclonal (Preservative Free) (MEM-43) Antibody
Human
ELISA, Flo, IF, IHC-Fr, IHC-P, IP, WB
Unconjugated, Preservative Free
1 mg/$1,091
CD59 Mouse anti-Human Monoclonal (Biotin) Antibody
Human
Flo
Biotin Conjugated
100 µg/$626
CD59 Rabbit anti-Pig Polyclonal (aa26-98) Antibody
Pig
WB
Unconjugated
100 µl/$322; 200 µl/$370; 500 µl/$529; 1 ml/$614; 2 ml/$846; 5 ml/$1,393
CD59 Rabbit anti-Human Recombinant Monoclonal (Azide-free, Carrier-free) (MACIF/2867R) Antibody
Human
IHC-P
Unconjugated, Azide-free, Carrier-free
100 µg/$574
CD59 Mouse anti-Rat Monoclonal (TH9) Antibody
Rat
Flo, Func, IHC, IHC-Fr, WB
Unconjugated
100 µg/$652
CD59 Mouse anti-Human Monoclonal (MEM-43) Antibody
Human
ELISA, Flo, IF, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50 µg/$460
CD59 Mouse anti-Mouse Monoclonal (7A6) Antibody
Mouse
Flo, Func, IF, IHC, IHC-Fr, WB
Unconjugated
100 µg/$516
CD59 Mouse anti-Mouse Monoclonal (FITC) (7A6) Antibody
Mouse
Flo, Func, IF, IHC, IHC-Fr, WB
FITC Conjugated
100 µg/$571
CD59 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
CD59 Rabbit anti-Human Polyclonal (aa26-102) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$313; 200 µl/$357; 500 µl/$503; 1 ml/$576; 2 ml/$788; 5 ml/$1,279
CD59 Mouse anti-Human Monoclonal (FITC) Antibody
Human
Flo, IHC, IHC-P
FITC Conjugated
60 Tests/$545
CD59 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
CD59 Rabbit anti-Human Monoclonal (Preservative Free) (015) Antibody
Human
ELISA
Unconjugated, Preservative Free
20 µl/$271; 100 µl/$412
CD59 Rabbit anti-Human Monoclonal (Preservative Free) (031) Antibody
Human
ELISA
Unconjugated, Preservative Free
20 µl/$271; 100 µl/$412
CD59 Rat anti-Human Monoclonal (YTH53.1) Antibody
Human
Flo, IHC, IHC-Fr, WB
Unconjugated
0.2 mg/$471
CD59 Rabbit anti-Rat Monoclonal (APC) (001) Antibody
Rat
Flo
APC Conjugated
25 Tests/$233; 100 Tests/$263
CD59 Rabbit anti-Rat Monoclonal (PE) (014) Antibody
Rat
Flo
PE Conjugated
25 Tests/$233; 100 Tests/$263
CD59 Rabbit anti-Rat Monoclonal (PE) (001) Antibody
Rat
Flo
PE Conjugated
25 Tests/$233; 100 Tests/$263
CD59 Rabbit anti-Rat Monoclonal (APC) (014) Antibody
Rat
Flo
APC Conjugated
25 Tests/$233; 100 Tests/$263
CD59 Mouse anti-Human Monoclonal (2E11B6) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$316; 100 µg/$386
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product results
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