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CD47

CD47 molecule

Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection.

Gene Name: CD47 molecule
Synonyms: CD47, CD47 antigen, CD47 molecule, Integrin associated protein, Integrin-associated protein, Leukocyte surface antigen CD47, MER6, Protein MER6, Rh-related antigen, OA3, CD47 glycoprotein, IAP
Target Sequences: NM_001777 NP_001768.1 Q08722

Publications (3)

1
CD47 is an adverse prognostic factor and a therapeutic target in gastric cancer. Yoshida K, Tsujimoto H, Matsumura K, Kinoshita M, Takahata R, Matsumoto Y, Hiraki S, Ono S, Seki S, Yamamoto J, Hase K. Cancer medicine. 2015 4:1322-33. (IP; Human) [Full Text Article] [PubMed:26077800] [PMC:PMC4567017]
2
Expression of CD47 antigen in Reed-Sternberg cells as a new potential biomarker for classical Hodgkin lymphoma. B López-Pereira, A A Fernández-Velasco, I Fernández-Vega, D Corte-Torres, C Quirós, J A Villegas, P Palomo, S González, A P González, Á Payer, T Bernal, M A Moro-García, R Alonso-Arias, S Alonso-Álvarez, E Colado. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. 2020 May;22:782-785. [Full Text Article] [PubMed:31359339]
3
Checkpoint CD47 expression in classical Hodgkin lymphoma. Alex Reza Gholiha, Peter Hollander, Liza Löf, Ingrid Glimelius, Gustaf Hedstrom, Daniel Molin, Henrik Hjalgrim, Karin E Smedby, Jamileh Hashemi, Rose-Marie Amini, Gunilla Enblad. British journal of haematology. 2022 June;197:580-589. [Full Text Article] [PubMed:35301709] [PMC:PMC9310712]

☰ Filters
Products
Proteins (37)
Over-Expression Lysate (4)
Recombinant (33)
CD47 (37)
Bind (4)
ELISA (4)
Func (4)
SDS-PAGE (6)
No (37)
6His, C-terminus (5)
6His, N-terminus (1)
6His-DDK (Flag), N-terminus (1)
AVI-6His, C-terminus (1)
DDK (Flag)-His, C-terminus (1)
DDK,C-terminus (1)
Fc (1)
Fc, C-terminus (8)
Fc-AVI, C-terminus (1)
GST (1)
His, N-Terminal (1)
His,C-terminus (5)
Human IgG Fc, C-terminus (2)
Human IgG1 Fc, C-terminus (1)
mFc, C-terminus (1)
Myc-DDK (Flag) (4)
Rabbit IgG Fc, C-terminus (1)
Human (22)
Monkey-Rhesus (1)
Mouse (9)
Rat (2)
Rhesus monkey (1)
293T Cells (2)
E. coli (2)
HEK 293 Cells (14)
Human (2)
Human Cells (6)
Mammalian Cells (9)
Sf9 Cells (1)
Wheat Germ Extract (1)
Purified (5)
Low endotoxin level (27)
Biologically active (6)
CD47 Protein - Recombinant Integrin Associated Protein By SDS-PAGE
Select
E. coli
6His, N-terminus
23.9 kDa
10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
16.7kD
10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
14.76kD
10 µg/$269; 50 µg/$372; 500 µg/$1,585; 1 mg/$2,157
Select
Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
40.8kD
10 µg/$321; 50 µg/$534; 500 µg/$1,680; 1 mg/$2,353
Select
HEK 293 Cells
His,C-terminus
Bind ELISA Func SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human CD47 consists 128 amino acids and predicts a molecular mass of 14.5 kDa.
100 µg/$480; 1 mg/$2,324
CD47 Protein
Select
HEK 293 Cells
Human IgG Fc, C-terminus
Bind ELISA Func SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human CD47/Fc is a disulfide-linked homodimer. The reduced monomer comprises 362 amino acids and has a predicted molecular mass of 40.7 kDa. The apparent molecular mass of the protein is approximately 48-60 kDa in SDS-PAGE under reducing conditions.
100 µg/$441; 1 mg/$2,003
Select
Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
40.8 kDa
100 µg/$721
Select
Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
42.8kD
10 µg/$266; 50 µg/$343; 500 µg/$1,377; 1 mg/$1,765
Select
HEK 293 Cells
Myc-DDK (Flag)
31.4 kDa
100 µg/$494
CD47 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
35.21 kDa
100 µg/$494
Select
293T Cells
Myc-DDK (Flag)
31.4 kDa
20 µg/$150
CD47 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
35.21 kDa
20 µg/$150
Select
HEK 293 Cells
His,C-terminus
Bind ELISA Func SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant mouse CD47 consists of 133 amino acids and predicts a molecular mass of 15.3 kDa.
50 µg/$348; 500 µg/$1,110
CD47 Protein
Select
HEK 293 Cells
Fc, C-terminus
20 µg/$1,107
CD47 Protein
Select
HEK 293 Cells
DDK (Flag)-His, C-terminus
20 µg/$1,107
Select
HEK 293 Cells
6His, C-terminus
Less than 0.2 EU/µg protein (determined by LAL method).
35-40 kDa
100 µg/$508; 1 mg/$1,717
CD47 Protein - Human CD47/IAP/OA3 (C-Avi-6His) Biotinylated
Select
Human
AVI-6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
16.4 kDa
20 µg/$416; 100 µg/$910
CD47 Protein - Recombinant Rhesus Macaque CD47/IAP/OA3 (N-6His-Flag)
Select
Human
6His-DDK (Flag), N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
15.7 kDa
10 µg/$356; 50 µg/$716
CD47 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Mammalian Cells
6His, C-terminus
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
14.76 kDa
50 µg/$424; 10 µg/$288; 1 mg/$2,837; 500 µg/$1,987
CD47 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Mammalian Cells
Fc, C-terminus
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
40.8 kDa
50 µg/$698; 10 µg/$356; 1 mg/$3,095; 500 µg/$2,167
Select
Mammalian Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
14.76 kDa
10 µg/$269; 50 µg/$368
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
16.7 kDa
10 µg/$281; 50 µg/$389
Select
HEK 293 Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
40.7 kDa
100 µg/$721; 1 mg/$4,701
Select
Mammalian Cells
Fc-AVI, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
42.7 kDa
20 µg/$416; 100 µg/$910
Select
Mammalian Cells
mFc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
40.3 kDa
10 µg/$262; 50 µg/$339
Viewing 1-25 of 37 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).