Recombinant Protein

CD47

Human

Unmodified

14.76 kDa

Mammalian Cells

Mammal

Greater than 95% by SDS-PAGE

Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection.

The ED50 as determined by its ability to bind Human SIRPA in functional ELISA is less than 20 ug/ml.

Less than 1.0 EU/µg protein (determined by LAL method).

Lyophilized from 0.2 µm filtered 10 mM Tris-Citrate, pH 8.0, 150 mM NaCl, 5% Mannitol

Store at -80°C for up to 1 year. Avoid freeze-thaw cycles.

For research use only. Intended for use by laboratory professionals.

This protein carries the LSBio 100% Guarantee.

Uniprot: Q08722 NCBI: NM_001777 NP_001768.1