CD46

CD46 molecule, complement regulatory protein

Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.

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Antibodies (127)

ELISA Kits (15)

Proteins (13)

Type

Custom (5)

Over-Expression Lysate (2)

Primary (127)

Recombinant (11)

Sandwich (9)

Sandwich CLIA (1)

Target

CD46 (155)

Reactivity

Human (96)

Mouse (31)

Rat (17)

Bovine (10)

Chicken (1)

Guinea pig (1)

Monkey (1)

Pig (21)

Porcine (1)

Rabbit (1)

Application

IHC (29)

IHC-Fr (6)

IHC-P (12)

WB (97)

Flo (66)

ELISA (25)

Func (5)

ICC (11)

IF (20)

IP (27)

Peptide-ELISA (1)

SDS-PAGE (1)

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Host

rabbit (62)

mouse (64)

rat (1)

Product Group

IHCPlus (4)

Isotype

IgG (31)

IgG1 (37)

IgG1,k (3)

IgG2a (13)

IgG2a,k (7)

Clonality

monoclonal mc (65)

polyclonal pc (62)

Clone

122.2 (2)

13/42 (1)

169-1-E4.3 (4)

169-1-EA.3 (4)

1A5A5 (1)

1E3D1 (1)

2E10 (1)

3F1 (2)

5A8C11 (1)

6D8/8 (1)

AT2G9 (1)

JM6C11 (1)

M177 (3)

MEM-258 (15)

MM1 (1)

MM10 (1)

TGP3 (2)

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Format

12 x 8-Well Microstrips (1)

96-Well Microplate (2)

96-Well Strip Plate (12)

APC (3)

APC Conjugated (8)

Azide-free (5)

Biotin Conjugated (13)

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Cy3 Conjugated (3)

Cy7 Conjugated (3)

FITC Conjugated (20)

HRP Conjugated (10)

PE Conjugated (12)

Preservative Free (2)

RPE Conjugated (2)

Unconjugated (56)

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Epitope

aa136-341 (8)

aa147-285 (8)

aa157-365 (8)

aa317-343 (7)

aa330-361 (1)

aa366-392 (1)

aa46-76 (1)

Publications

No (154)

Yes (1)

Sample Type

Plasma (5)

Saliva (1)

Serum (5)

Tissue Homogenates (1)

Urine (1)

Tag

6His, C-terminus (2)

6His, N-terminus (1)

GST (1)

GST, N-terminus (1)

His (3)

His,C-terminus (1)

His-GST (2)

Myc-DDK (Flag) (2)

Species

Guinea pig (1)

Human (8)

Mouse (2)

Rat (1)

Source

293T Cells (1)

E. coli (6)

HEK 293 Cells (2)

Human Cells (1)

Mammalian Cells (1)

Wheat Germ Extract (2)

Purification

Purified (4)

Low Endotoxin Level

Low endotoxin level (3)

Select

IHC-plus™ CD46 Antibody (clone MEM-258) LS-B5950

(4.0) Rating

Antibody:

CD46 Mouse anti-Human Monoclonal (MEM-258) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

0.05 mg/$460

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CD46 Antibody (clone MEM-258, RPE) LS-C44291

Antibody:

CD46 Mouse anti-Human Monoclonal (RPE) (MEM-258) Antibody

Reactivity:

Human

Applications:

Flo

Format:

RPE Conjugated

Price:

100 Tests/$485

• Unconjugated
• RPE

• Unconjugated
• RPE

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IHC-plus™ CD46 Antibody (clone 3F1) LS-B6754

(4.0) Rating

Antibody:

CD46 Mouse anti-Human Monoclonal (3F1) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$485

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CD46 Antibody (clone 13/42) LS-C96281

(4.0) Rating

(1) Publication(s)

Antibody:

CD46 Mouse anti-Human Monoclonal (13/42) Antibody

Reactivity:

Human

Applications:

IHC, IHC-Fr, IHC-P

Format:

Unconjugated

Price:

200 µg/$595

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CD46 Antibody (clone MM10) LS-C210254

Antibody:

CD46 Rat anti-Mouse Monoclonal (MM10) Antibody

Reactivity:

Mouse, Rat

Applications:

Flo, IF, IHC, IHC-Fr, WB

Format:

Unconjugated

Price:

100 µg/$554

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CD46 Antibody LS-C331615

Antibody:

CD46 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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IHC-plus™ CD46 Antibody (clone M177, Concentrated) LS-B11245

(4.0) Rating

Antibody:

CD46 Mouse anti-Human Monoclonal (Concentrated) (M177) Antibody

Reactivity:

Human

Applications:

Flo, IHC, IHC-Fr, IHC-P, IP, WB

Format:

Unconjugated, Concentrated

Price:

50 µg/$565

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CD46 Antibody (clone MEM-258, Azide-free) LS-C45713

Antibody:

CD46 Mouse anti-Human Monoclonal (Azide-free) (MEM-258) Antibody

Reactivity:

Bovine, Human

Applications:

Flo, IP, WB

Format:

Unconjugated, Azide-free

Price:

0.1 mg/$309

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IHC-plus™ CD46 Antibody (clone 169-1-EA.3, Azide-free) LS-B12666

(4.0) Rating

Antibody:

CD46 Mouse anti-Human Monoclonal (Azide-free) (169-1-EA.3) Antibody

Reactivity:

Human

Applications:

Flo, IHC, IHC-P, WB

Format:

Unconjugated, Azide-free

Price:

50 µg/$460

Select

CD46 Antibody (aa317-343) LS-C168544

Antibody:

CD46 Rabbit anti-Human Polyclonal (aa317-343) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

CD46 Antibody (FITC) LS-C121150

Antibody:

CD46 Mouse anti-Human Monoclonal (FITC) Antibody

Reactivity:

Human

Applications:

Flo, IHC, IHC-Fr, IHC-P, IP, WB

Format:

FITC Conjugated

Price:

100 µg/$873

Select

CD46 Antibody LS-C490163

Antibody:

CD46 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$575

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CD46 Antibody LS-C661787

Antibody:

CD46 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IP, WB

Format:

Unconjugated

Price:

100 µg/$331

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CD46 Antibody (clone MEM-258, APC) LS-C46219

Antibody:

CD46 Mouse anti-Human Monoclonal (APC) (MEM-258) Antibody

Reactivity:

Bovine, Human

Applications:

Flo, IP, WB

Format:

APC Conjugated

Price:

100 Tests/$365

Select

CD46 Antibody (FITC) LS-C35633

Antibody:

CD46 Mouse anti-Human Monoclonal (FITC) Antibody

Reactivity:

Human

Applications:

Flo, WB

Format:

FITC Conjugated

Price:

120 Tests/$626

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CD46 Antibody (clone 1A5A5) LS-C828376

Antibody:

CD46 Mouse anti-Human Monoclonal (1A5A5) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

Unconjugated

Price:

100 µg/$459

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CD46 Antibody (clone 5A8C11) LS-C828301

Antibody:

CD46 Mouse anti-Human Monoclonal (5A8C11) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, WB

Format:

Unconjugated

Price:

100 µg/$459

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CD46 Antibody (aa317-343) LS-C320185

Antibody:

CD46 Rabbit anti-Human Polyclonal (aa317-343) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

CD46 Antibody (aa317-343, Biotin) LS-C221701

Antibody:

CD46 Rabbit anti-Human Polyclonal (aa317-343) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IF, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

CD46 Antibody (aa317-343, FITC) LS-C221702

Antibody:

CD46 Rabbit anti-Human Polyclonal (aa317-343) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IF, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

CD46 Antibody (aa317-343, PE) LS-C221704

Antibody:

CD46 Rabbit anti-Human Polyclonal (aa317-343) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, ICC, IF, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

Select

CD46 Antibody (aa317-343, APC) LS-C221700

Antibody:

CD46 Rabbit anti-Human Polyclonal (aa317-343) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IF, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

CD46 Antibody (aa317-343, Azide-free, HRP) LS-C221703

Antibody:

CD46 Rabbit anti-Human Polyclonal (aa317-343) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IF, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• PE
• APC
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • PE
  • APC
  • HRP, Azide-free

Select

CD46 Antibody (FITC) LS-C484953

Antibody:

CD46 Mouse anti-Human Monoclonal (FITC) Antibody

Reactivity:

Human

Applications:

Flo

Format:

FITC Conjugated

Price:

25 Tests/$263; 100 Tests/$323

Select

CD46 Antibody (clone AT2G9) LS-C755423

Antibody:

CD46 Mouse anti-Human Monoclonal (AT2G9) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IHC, WB

Format:

Unconjugated

Price:

50 µl/$303; 100 µl/$365

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