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CD28

CD28 molecule

Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.

Gene Name: CD28 molecule
Synonyms: CD28, CD28 antigen, CD28 antigen (Tp44), Tp44, CD28 molecule
Target Sequences: NM_006139 NP_006130.1 P10747

Publications (8)

1
A major role of PKC theta and NFkappaB in the regulation of hTERT in human T lymphocytes. Sheng WY, Chen YR, Wang TC. FEBS letters. 2006 580:6819-24. [PubMed:17141225] Related Antibodies: LS-C40963.
2
Ex vivo simulation of drug action: quantification of drug-induced mRNA as a bridge between preclinical and clinical trials. Mitsuhashi M. Clinical chemistry. 2007 53:148-9. [PubMed:17202503] Related Antibodies: LS-C40963.
3
Human amnion mesenchyme harbors cells with allogeneic T-cell suppression and stimulation capabilities. Magatti M, De Munari S, Vertua E, Gibelli L, Wengler GS, Parolini O. Stem cells (Dayton, Ohio). 2008 26:182-92. [PubMed:17901399] Related Antibodies: LS-C40963.
4
Regulation of CD28 expression on CD8+ T cells by CTLA-4. Berg M, Zavazava N. Journal of leukocyte biology. 2008 83:853-63. [PubMed:18162511] Related Antibodies: LS-C40963.
5
Burkholderia pseudomallei infection of T cells leads to T-cell costimulation partially provided by flagellin. Ye Z, Lee CM, Sun GW, Gan YH. Infection and immunity. 2008 76:2541-50. [PubMed:18347031] [PMC:PMC2423057] Related Antibodies: LS-C40963.
6
HIV-1 Nef disrupts intracellular trafficking of major histocompatibility complex class I, CD4, CD8, and CD28 by distinct pathways that share common elements. Leonard JA, Filzen T, Carter CC, Schaefer M, Collins KL. Journal of virology. 2011 85:6867-81. [PubMed:21543478] [PMC:PMC3126561] Related Antibodies: LS-C40963.
7
Association of major histocompatibility complex class I haplotypes with disease progression after simian immunodeficiency virus challenge in burmese rhesus macaques. Nomura T, Yamamoto H, Shiino T, Takahashi N, Nakane T, Iwamoto N, Ishii H, Tsukamoto T, Kawada M, Matsuoka S, Takeda A, Terahara K, Tsunetsugu-Yokota Y, Iwata-Yoshikawa N, Hasegawa H, Sata T, Naruse TK, Kimura A, Matano T. Journal of virology. 2012 86:6481-90. [PubMed:22491464] [PMC:PMC3393527] Related Antibodies: LS-C40963.
8
A non-conserved amino acid variant regulates differential signalling between human and mouse CD28. Porciello N, Grazioli P, Campese AF, Kunkl M, Caristi S, Mastrogiovanni M, Muscolini M, Spadaro F, Favre C, Nunès JA, Borroto A, Alarcon B, Screpanti I, Tuosto L. Nature communications. 2018 March;9:1080. (Mouse) [Full Text Article] [PubMed:29540686] [PMC:PMC5852078]
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☰ Filters
Products
Proteins (23)
Over-Expression Lysate (2)
Recombinant (21)
CD28 (23)
SDS-PAGE (1)
Preservative Free (1)
No (23)
6His, N-terminus (1)
DDK (Flag)-His, C-terminus (1)
Fc, C-terminus (3)
Fc/6His,C-terminus (1)
Fc-6His, C-terminus (1)
Fc-AVI, C-terminus (1)
GST (1)
His (1)
His, N-Terminal (1)
His,C-terminus (1)
Human IgG1 Fc (1)
Human IgG1 Fc, C-terminus (1)
mFc, C-terminus (1)
Mouse IgG2a Fc, N-terminus (1)
Myc-DDK (Flag) (2)
Human (15)
Mouse (6)
293T Cells (1)
CHO Cells (6)
E. coli (1)
HEK 293 Cells (5)
Human (2)
Human Cells (4)
Mammalian Cells (3)
Wheat Germ Extract (1)
Purified (5)
Low endotoxin level (13)
Biologically active (3)
Select
CHO Cells
Human IgG1 Fc
Less than 0.06 EU/µg protein (determined by LAL method).
200 µg/$498
Select
CHO Cells
Mouse IgG2a Fc, N-terminus
Less than 0.06 EU/µg protein (determined by LAL method).
200 µg/$498
CD28 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
25.07 kDa
100 µg/$494
CD28 Protein
Select
HEK 293 Cells
His,C-terminus
SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
The secreted mature form of mouse CD28 consists of 141 amino acids and has a predicted molecular mass of 16.5 kDa. Due to glycosylation, the apparent molecular mass of rmCD28 is approximately 32-35 kDa in SDS-PAGE under reducing conditions.
100 µg/$403; 1 mg/$1,697
CD28 Protein - Recombinant Cluster Of Differentiation 28 By SDS-PAGE
Select
E. coli
His, N-Terminal
48.4 kDa
50 µg/$442; 10 µg/$281; 200 µg/$882; 100 µg/$705; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
Select
CHO Cells
None
25 µg/$575
Select
CHO Cells
None
25 µg/$575
CD28 Protein
Select
CHO Cells
None
25 µg/$698
Select
CHO Cells
None
Biologically active
82.4 kDa or 60-70 kDa or 150-160 kDa
100 µg/$349; 20 µg/$268
Select
HEK 293 Cells
Human IgG1 Fc, C-terminus
Less than 0.2 EU/µg protein (determined by LAL method).
66-70 kDa
100 µg/$338; 1 mg/$1,475
CD28 Protein
Select
HEK 293 Cells
Fc, C-terminus
40 kDa
20 µg/$1,107
CD28 Protein
Select
HEK 293 Cells
DDK (Flag)-His, C-terminus
18 kDa
20 µg/$1,107
Select
Human
6His, N-terminus
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
16.7 kDa
10 µg/$290; 50 µg/$446
CD28 Protein - Recombinant Human/Cynomolyus CD28/TP44 (C-Fc-Avi) Biotinylated
Select
Human
Fc-AVI, C-terminus
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
44.1 kDa
20 µg/$428; 100 µg/$834
CD28 Protein - 12.5% SDS-PAGE of human CD28 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
51.5 kDa
2 µg/$439
Select
Human Cells
None
Less than 1.0 EU/µg protein (determined by LAL method).
15.9 kDa
100 µg/$532
CD28 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
25.07 kDa
20 µg/$150
Select
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
41.11 kDa
10 µg/$233; 50 µg/$269
Select
Mammalian Cells
Fc/6His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
43.0 kDa
10 µg/$233; 50 µg/$269
Select
Mammalian Cells
mFc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
41.7 kDa
10 µg/$281; 50 µg/$389
Select
Human Cells
Fc-6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
43kD
10 µg/$233; 50 µg/$269; 500 µg/$508; 1 mg/$664
Select
Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
42.3kD
10 µg/$233; 50 µg/$269; 500 µg/$844; 1 mg/$1,245
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
16.5 kDa
100 µg/$661; 1 mg/$3,499
Viewing 1-23 of 23 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).