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CD274 / B7-H1 / PD-L1
CD274 molecule
CD274, also known as B7-H1 and PD-L1, a cell surface glycoprotein, is a member of the B7 family of co-stimulatory molecules. CD274 is expressed constitutively on macrophages and dendritic cells, and is induced on activated T-cells, B-cells, endothelial cells and epithelial cells in response to interferons. CD274 has dual functions: inhibition of activated effector T cells and co-stimulation of naïve T cells. It inhibits proliferation of activated T cells via ligation to the co-inhibitory molecule CD279 (programmed death-1; PD-1) leading to the secretion of the regulatory cytokine interleukin-10. Expression of CD274 in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma.
| Gene Name: | CD274 molecule |
| Synonyms: | CD274, B7-H, B7 homolog 1, B7-H1, B7H1, CD274 molecule, CD274 antigen, PDCD1 ligand 1, PDL1, PD-L1, PDCD1L1, PDCD1LG1, Programmed death ligand 1 |
| Target Sequences: | NM_014143 NP_054862.1 Q9NZQ7 |
Publications (19)
1
BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma. Frederick DT, Piris A, Cogdill AP, Cooper ZA, Lezcano C, Ferrone CR, Mitra D, Boni A, Newton LP, Liu C, Peng W, Sullivan RJ, Lawrence DP, Hodi FS, Overwijk WW, Lizée G, Murphy GF, Hwu P, Flaherty KT, Fisher DE, Wargo JA. Clinical cancer research : an official journal of the American Association for Cancer Research. 2013 19:1225-31. (WB; Human)
[Full Text Article]
[PubMed:23307859]
[PMC:PMC3752683]
2
Programmed cell death protein 1 and programmed death-ligand 1 are expressed on the surface of some small-cell lung cancer lines. Yamane H, Isozaki H, Takeyama M, Ochi N, Kudo K, Honda Y, Yamagishi T, Kubo T, Kiura K, Takigawa N. American journal of cancer research. 2015 5:1553-7. (Flo; Human)
[PubMed:26101718]
[PMC:PMC4473331]
3
Characterization of myeloid leukocytes and soluble mediators in pancreatic cancer: importance of myeloid-derived suppressor cells. Karakhanova S, Link J, Heinrich M, Shevchenko I, Yang Y, Hassenpflug M, Bunge H, von Ahn K, Brecht R, Mathes A, Maier C, Umansky V, Werner J, Bazhin AV. Oncoimmunology. 2015 4:e998519. (Flo; Mouse)
[Full Text Article]
[PubMed:26137414]
[PMC:PMC4485765]
☰ Filters
Products
Proteins
(55)
Type
Over-Expression Lysate
(2)
Recombinant
(53)
Target
CD274 / B7-H1 / PD-L1
(55)
Application
Bind
(5)
ELISA
(5)
Func
(5)
SDS-PAGE
(6)
Format
Preservative Free
(1)
Publications
No
(55)
Tag
6His, C-terminus
(5)
DDK (Flag)-His, C-terminus
(1)
DDK,C-terminus
(3)
Fc, C-terminus
(9)
Fc-AVI, C-terminus
(1)
Flag,C-terminus
(1)
GST, N-terminus
(1)
His
(4)
His,C-terminus
(7)
His-GST
(1)
His-T7
(3)
Human IgG Fc, C-terminus
(1)
Human IgG1 Fc
(1)
Human Mutant IgG1 Fc
(1)
mFc, C-terminus
(2)
Mouse IgG1 Fc, C-terminus
(1)
Mouse IgG2 Fc
(1)
Mouse IgG2a Fc, N-terminus
(1)
Mouse Mutant IgG2a Fc
(1)
Myc-DDK (Flag)
(2)
Species
Crab-eating macaque
(2)
Human
(36)
Mouse
(13)
Rat
(3)
Source
293T Cells
(1)
CHO Cells
(9)
E. coli
(7)
HEK 293 Cells
(17)
Human Cells
(7)
Mammalian Cells
(11)
Sf9 Cells
(2)
Wheat Germ Extract
(1)
Purification
Purified
(11)
Low Endotoxin Level
Low endotoxin level
(36)
Biologically Active
Biologically active
(10)
E. coli
His-GST
53.7 kDa
10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
25.6kD
10 µg/$248; 50 µg/$288; 500 µg/$785; 1 mg/$1,203
E. coli
271 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
29.92 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
E. coli
His
20 µg/$261; 100 µg/$323; 10 µg/$242; 250 µg/$365; 500 µg/$515
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
26.33kD
10 µg/$240; 50 µg/$299; 500 µg/$929; 1 mg/$1,245
Human Cells
DDK,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
26.3kD
10 µg/$258; 50 µg/$321; 500 µg/$1,262; 1 mg/$1,627
Human Cells
mFc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
50.9kD
10 µg/$258; 50 µg/$321; 500 µg/$1,262; 1 mg/$1,627
Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
51.7kD
10 µg/$248; 50 µg/$288; 500 µg/$785; 1 mg/$1,203
HEK 293 Cells
His,C-terminus
Bind ELISA Func SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant mature human B7-H1 comprises 232 amino acids and predicts a molecular mass of 26.8 kDa. As a result of glycosylation, the rh B7-H1 migrates as an approximately 35-38 kDa protein in SDS-PAGE under reducing conditions.
100 µg/$441; 1 mg/$2,003
HEK 293 Cells
None
Bind ELISA Func SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant mature human B7-H1/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 459 amino acids and predicts a molecular mass of 52 kDa. As a result of glycosylation, the rh B7-H1/Fc monomer migrates as an approximately 65-70 kDa protein in SDS-PAGE under reducing conditions.
100 µg/$441; 1 mg/$2,261
HEK 293 Cells
Mouse IgG1 Fc, C-terminus
Bind ELISA Func SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human CD274 consists of 455 amino acids and predicts a molecular mass of 51.7 kDa.
100 µg/$372; 1 mg/$1,498
HEK 293 Cells
His,C-terminus
Bind ELISA Func SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The secreted recombinant mouse CD274 comprises 231 amino acids and has a predicted molecular mass of 26.3 kDa. As a result of glycosylation, it migrates as an approximately 40-45 kDa band in SDS-PAGE under reducing conditions.
100 µg/$403; 1 mg/$1,697
Mouse CD274 / B7-H1 / PD-L1 Protein (Recombinant Human IgG Fc, C-terminus) (Met1-His239) - LS-G51189
HEK 293 Cells
Human IgG Fc, C-terminus
Bind ELISA Func SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant mouse Cd274 consists 459 amino acids and predicts a molecular mass of 51.6 kDa.
100 µg/$348; 1 mg/$1,345
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
293T Cells
Myc-DDK (Flag)
33.28 kDa
20 µg/$150
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
26.3 kDa
100 µg/$661; 1 mg/$3,499
Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
52.4kD
10 µg/$258; 50 µg/$321; 500 µg/$1,262; 1 mg/$1,627
HEK 293 Cells
Myc-DDK (Flag)
33.28 kDa
100 µg/$494
HEK 293 Cells
Fc, C-terminus
50 kDa
20 µg/$1,107
HEK 293 Cells
DDK (Flag)-His, C-terminus
20 µg/$1,107
HEK 293 Cells
Fc, C-terminus
50 kDa
20 µg/$1,107
HEK 293 Cells
6His, C-terminus
Less than 0.2 EU/µg protein (determined by LAL method).
31-35 kDa
100 µg/$338; 1 mg/$1,475
HEK 293 Cells
None
Biologically active
Less than 0.01 EU/µg protein (determined by LAL method).
~35 kDa (SDS-PAGE)
50 µg/$442
HEK 293 Cells
Mouse IgG2a Fc, N-terminus
Biologically active
Less than 5.0 EU/mg protein (determined by LAL method).
~70 kDa (SDS-PAGE)
100 µg/$463
Viewing 1-25
of 55
product results
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