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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States

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Customer Service: (800) 227-6666 / (650) 697-3600


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CD14

CD14 molecule

In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the MD-2/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.

Gene Name: CD14 molecule
Synonyms: CD14, CD14 molecule, CD14 antigen
Target Sequences: NM_000591 NP_000582.1 P08571

Publications (11)

1
TNF-alpha drives human CD14+ monocytes to differentiate into CD70+ dendritic cells evoking Th1 and Th17 responses. Iwamoto S, Iwai S, Tsujiyama K, Kurahashi C, Takeshita K, Naoe M, Masunaga A, Ogawa Y, Oguchi K, Miyazaki A. Journal of immunology (Baltimore, Md. : 1950). 2007 179:1449-57. [PubMed:17641010] Related Antibodies: LS-C41087.
2
C1q deficiency leads to the defective suppression of IFN-alpha in response to nucleoprotein containing immune complexes. Santer DM, Hall BE, George TC, Tangsombatvisit S, Liu CL, Arkwright PD, Elkon KB. Journal of immunology (Baltimore, Md. : 1950). 2010 185:4738-49. [PubMed:20844193] [PMC:PMC3065655] Related Antibodies: LS-C41087.
3
LPS-induced TLR4 signaling in human colorectal cancer cells increases beta1 integrin-mediated cell adhesion and liver metastasis. Hsu RY, Chan CH, Spicer JD, Rousseau MC, Giannias B, Rousseau S, Ferri LE. Cancer research. 2011 71:1989-98. (IHC) [PubMed:21363926]
4
LPS stimulation of purified human platelets is partly dependent on plasma soluble CD14 to secrete their main secreted product, soluble-CD40-Ligand. Damien P, Cognasse F, Eyraud MA, Arthaud CA, Pozzetto B, Garraud O, Hamzeh-Cognasse H. BMC immunology. 2015 16:3. (Flo; Human) [Full Text Article] [PubMed:25636826] [PMC:PMC4322959] Related Antibodies: LS-C140133.
5
MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment. Riesenberg S, Groetchen A, Siddaway R, Bald T, Reinhardt J, Smorra D, Kohlmeyer J, Renn M, Phung B, Aymans P, Schmidt T, Hornung V, Davidson I, Goding CR, Jönsson G, Landsberg J, Tüting T, Hölzel M. Nature communications. 2015 6:8755. (ICC; Human) [Full Text Article] [PubMed:26530832] [PMC:PMC4659938]
6
MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy. Julia Reinhardt, Jennifer Landsberg, Jonathan L Schmid-Burgk, Bartomeu Bibiloni Ramis, Tobias Bald, Nicole Glodde, Dorys Lopez-Ramos, Arabella Young, Shin Foong Ngiow, Daniel Nettersheim, Hubert Schorle, Thomas Quast, Waldemar Kolanus, Dirk Schadendorf, Georgina V Long, Jason Madore, Richard A Scolyer, Antoni Ribas, Mark J Smyth, Paul C Tumeh, Thomas Tüting, Michael Hölzel. Cancer research. 2017 September;77:4697-4709. [Full Text Article] [PubMed:28652246]
7
Rapid recruitment of CD14(+) monocytes in experimentally induced allergic rhinitis in human subjects. Ibon Eguíluz-Gracia, Anthony Bosco, Ralph Dollner, Guro Reinholt Melum, Maria H Lexberg, Anya C Jones, Sinan Ahmed Dheyauldeen, Patrick G Holt, Espen S Bækkevold, Frode Lars Jahnsen. The Journal of allergy and clinical immunology. 2016 June;137:1872-1881.e12. [Full Text Article] [PubMed:26851967] Related Antibodies: LS-C140133.
8
Increased plasma CD14 levels 1 year postpartum in women with pre-eclampsia during pregnancy: a case-control plasma proteomics study. Antigoni Manousopoulou , Fatma S Abad , Diana J Garay-Baquero, Brian R Birch, Bas B van Rijn, Bashir A Lwaleed , Spiros D Garbis. Nutrition & diabetes. 2020 Jan;10:2. [Full Text Article] [PubMed:32066653] [PMC:PMC7026086]
9
Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD3910<sup> Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. fquintana@rics.bwh.harvard.edu. Maisa C Takenaka, Galina Gabriely, Veit Rothhammer, Ivan D Mascanfroni, Michael A Wheeler, Chun-Cheih Chao, Cristina Gutiérrez-Vázquez, Jessica Kenison, Emily C Tjon, Andreia Barroso, Tyler Vandeventer, Kalil Alves de Lima, Sonja Rothweiler, Lior Mayo, Soufiene Ghannam, Stephanie Zandee, Luke Healy, David Sherr, Mauricio F Farez , Alexandre Prat, Jack Antel, David A Reardon, Hailei Zhang, Simon C Robson, Gad Getz, Howard L Weiner, Francisco J Quintana. Nature neuroscience. 2019 May;;22:729-740. [Full Text Article] [PubMed:30962630] [PMC:PMC8052632] Related Antibodies: LS-B3012.
10
P2Y12 receptor is expressed on human microglia under physiological conditions throughout development and is sensitive to neuroinflammatory diseases. Alexander Mildner, Hao Huang, Josefine Radke, Werner Stenzel, Josef Priller. Glia. 2017 Feburary;65:375-387. [Full Text Article] [PubMed:27862351] Related Antibodies: LS-B3012.
11
EFFECT OF LIPOSOMAL CLODRONATE-DEPENDENT DEPLETION OF PROFESSIONAL ANTIGEN PRESENTING CELLS ON NUMBERS AND PHENOTYPE OF CANINE CD4+CD25+FOXP3+ REGULATORY T CELLS. Weaver KF, Stokes JV, Gunnoe SA, Follows JS, Shafer L, Ammari MG, Archer TM, Thomason JM, Mackin AJ, Pinchuk LM. Journal of veterinary medicine and research. 2014 1: (Flo; Canine) [PubMed:25950023] [PMC:PMC4418640] Related Antibodies: LS-C43762.
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CD14 Antibody - Anti-CD14 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 4 ug/ml.
Select
IHC-plus™ CD14 Antibody (aa71-84) LS-B3012
(5.0) Rating
(2) Publication(s)
CD14 Goat anti-Human Polyclonal (aa71-84) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
Select
CD14 Antibody (clone TÜK4, FITC) LS-C43762
(4.0) Rating
(1) Publication(s)
CD14 Mouse anti-Human Monoclonal (FITC) (TÜK4) Antibody
Human
Flo
FITC Conjugated
25 µg/$281; 0.1 mg/$432
CD14 Antibody - Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with CD14 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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CD14 Antibody (aa54-83) LS-C100021
CD14 Rabbit anti-Human Polyclonal (aa54-83) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
CD14 Antibody - IHC of paraffin-embedded stomach cancer tissues using CD14 mouse monoclonal antibody with DAB staining.
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CD14 Antibody (aa20-214, clone 4B4F12) LS-C285884
CD14 Mouse anti-Human Monoclonal (aa20-214) (4B4F12) Antibody
Mouse, Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
100 µl/$459
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CD14 Antibody (clone UCHM1) LS-C122948
CD14 Mouse anti-Human Monoclonal (UCHM1) Antibody
Human, Monkey, Cynomolgus
Flo, IHC, IHC-Fr, IP
Unconjugated
100 µg/$562; 200 µg/$755
CD14 Antibody - Surface staining of human peripheral blood leukocytes using anti-human CD14 (clone MEM-18) FITC.
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CD14 Antibody (aa57-64, clone MEM-18, FITC) LS-C46346
CD14 Mouse anti-Human Monoclonal (aa57-64) (FITC) (MEM-18) Antibody
Human, Non-Human Primates
ELISA, Flo, Func, IP, WB
FITC Conjugated
100 Tests/$337
Select
CD14 Antibody LS-C127470
CD14 Mouse anti-Human Monoclonal Antibody
Rabbit, Goat, Dog, Sheep, Bovine, Mink, Pig, Cat, Cynomolgus, Human, Monkey
ELISA, Flo
Unconjugated
100 µg/$562; 200 µg/$755
Select
CD14 Antibody (PE) LS-C78301
CD14 Mouse anti-Pig Monoclonal (PE) Antibody
Pig
ELISA, Flo, WB
PE Conjugated
100 µg/$896
CD14 Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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CD14 Antibody (clone 7) LS-C311975
CD14 Mouse anti-Human Monoclonal (7) Antibody
Human
IHC-Fr, IHC-P
Unconjugated
0.1 ml/$346
CD14 Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
PathPlus™ CD14 Antibody (clone 7) LS-B16173
Cancer Pathology
Cancer
(5.0) Rating
CD14 Mouse anti-Human Monoclonal (7) Antibody
Human
IHC-Fr, IHC-P
Unconjugated
0.05 ml/$460
CD14 Antibody - IHC of CD14 on FFPE Placenta tissue. This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
CD14 Antibody (clone 7, Ready-to-Use) LS-C348364
CD14 Mouse anti-Human Monoclonal (Ready-to-Use) (7) Antibody
Human
IHC-Fr, IHC-P
Unconjugated, Ready-to-Use
3 ml/$341
Select
CD14 Antibody (clone TÜK4, RPE) LS-C43764
CD14 Mouse anti-Human Monoclonal (RPE) (TÜK4) Antibody
Human
Flo
RPE Conjugated
100 Tests/$485
Select
CD14 Antibody (PE) LS-C4609
CD14 Mouse anti-Human Monoclonal (PE) Antibody
Dog, Sheep, Bovine, Pig, Cat, Human, Monkey
Flo
PE Conjugated
100 Tests/$755
CD14 Antibody - Flow cytometry of human peripheral blood monocytes with Mouse anti-Human CD14:Biotin This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CD14 Antibody (clone TÜK4, Biotin) LS-C188147
CD14 Mouse anti-Human Monoclonal (Biotin) (TÜK4) Antibody
Human
Flo
Biotin Conjugated
0.1 mg/$432
CD14 Antibody - Human peripheral blood monocytes stained with M5E2 APC.
Select
CD14 Antibody (clone M5E2) LS-C41087
(4.1) Rating
(2) Publication(s)
CD14 Mouse anti-Human Monoclonal (M5E2) Antibody
Dog, Human, Monkey
Flo, IHC, IHC-Fr
Unconjugated
25 µg/$238; 100 µg/$269
CD14 ELISA Kit
Select
Rat CD14 (Sandwich ELISA) ELISA Kit - LS-F4858
Sandwich
96-Well Strip Plate
Rat
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$715
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Human CD14 Protein (Recombinant 6His, C-terminus) (Thr20-Cys352) - LS-G38840
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
36.81kD
10 µg/$269; 50 µg/$372; 500 µg/$1,585; 1 mg/$2,157
Select
CD14 Antibody (clone 18D11) LS-C140133
(4.1) Rating
(2) Publication(s)
CD14 Mouse anti-Human Monoclonal (18D11) Antibody
Human
Flo, Func
Unconjugated
100 µg/$516
Select
CD14 Antibody (clone Tuk4, FITC) LS-C4606
CD14 Mouse anti-Human Monoclonal (FITC) (Tuk4) Antibody
Goat, Dog, Sheep, Bovine, Pig, Cat, Human, Monkey
Flo
FITC Conjugated
100 Tests/$672
CD14 ELISA Kit
Select
Human CD14 (Sandwich ELISA) ELISA Kit - LS-F4460
(4.0) Rating
(1) Publication(s)
Sandwich
96-Well Strip Plate
Human
0.94 - 60 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum
1 Plate/$764
CD14 Antibody - CD14
Select
CD14 Antibody (clone MEM18) LS-C347410
CD14 Mouse anti-Human Monoclonal (MEM18) Antibody
Human
Flo, IF
Unconjugated
0.2 mg/$381
Select
CD14 Antibody (clone UCHM-1, FITC) LS-C351591
CD14 Mouse anti-Human Monoclonal (FITC) (UCHM-1) Antibody
Human
Flo, IHC, IHC-Fr
FITC Conjugated
100 Tests/$367
CD14 Antibody - Overlay histogram showing huuman peripheral blood monocytes stained with CD14 antibody (green line). The cells were icubated in 2% bovine serum albumin to block non-specific protein-protein interactions followed by the antibody (1:50 dilution) for 60min at 37°C. The secondary antibody used was Goat Anti-Mouse IgG, DyLight® 488 Conjugated Highly Cross-Adsorbed (OJ192088) at 1/200 dilution for 40min at 37°C. Isotype control antibody (blue line) was mouse IgG2b (1µg/1x10^6 cells) used under the same conditions. Acquisition of >10, 000 events was performed.
Select
CD14 Antibody (clone 3C10 Equivalent) LS-C757972
CD14 Mouse anti-Human Monoclonal (3C10 Equivalent) Antibody
Human
ELISA, Flo
Unconjugated
200 µl/$393
CD14 Antibody - IHC of paraffin-embedded cervical cancer tissues using CD14 mouse monoclonal antibody with DAB staining.
Select
CD14 Antibody (aa20-214, clone 1H5D8) LS-C285883
CD14 Mouse anti-Human Monoclonal (aa20-214) (1H5D8) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$459
CD14 Antibody - Immunohistochemistry - Anti-CD14 Picoband antibody
Select
CD14 Antibody LS-C662605
CD14 Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$407
Viewing 1-25 of 311 product results



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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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