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CCL21 / SLC

chemokine (C-C motif) ligand 21

This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19).

Gene Name: chemokine (C-C motif) ligand 21
Family/Subfamily: Intercrine , Intercrine beta
Synonyms: CCL21, 6Ckine, Beta chemokine exodus-2, C-C motif chemokine 21, Beta-chemokine exodus-2, CKb9, ECL, Small-inducible cytokine A21, SCYA21, SLC, Exodus-2, TCA4
Target Sequences: NM_002989 NP_002980.1 O00585

Publications (4)

1
Integrated pharmacokinetic, pharmacodynamic and immunogenicity profiling of an anti-CCL21 monoclonal antibody in cynomolgus monkeys. Dudal S, Subramanian K, Flandre T, Law WS, Lowe PJ, Skerjanec A, Genin JC, Duval M, Piequet A, Cordier A, Jarai G, Van Heeke G, Taplin S, Krantz C, Jones S, Warren AP, Brennan FR, Sims J, Lloyd P. mAbs. 2015 7:829-37. (WB; Human) [Full Text Article] [PubMed:26230385] [PMC:PMC4622749] Related Antibodies: LS-C104622.
2
Renal allograft rejection, lymphocyte infiltration, and de novo donor-specific antibodies in a novel model of non-adherence to immunosuppressive therapy. Kühne L, Jung B, Poth H, Schuster A, Wurm S, Ruemmele P, Banas B, Bergler T. BMC immunology. 2017 December;18:52. (Mouse) [Full Text Article] [PubMed:29258420] [PMC:PMC5735914]
3
CD8+ T cell immunity blocks the metastasis of carcinogen-exposed breast cancer. Kaiwen Li, Tiancheng Li, Zhaoyi Feng, Mei Huang, Lei Wei, Zhiyu Yan, Mark Long, Qiang Hu, Jianmin Wang, Song Liu, Dennis C Sgroi, Shadmehr Demehri. Science advances. 2021 June;7: [Full Text Article] [PubMed:34144976] [PMC:PMC8213232]
4
Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells. Beth Lucas, Andrea J White, Emilie J Cosway, Sonia M Parnell, Kieran D James, Nick D Jones, Izumi Ohigashi, Yousuke Takahama, William E Jenkinson, Graham Anderson. Nature communications. 2020 May;11:2198. [Full Text Article] [PubMed:32366944] [PMC:PMC7198500] Related Antibodies: LS-C104634.
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Antibodies (69)
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CCL21 / SLC (113)
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CCL21 / SLC Antibody - Western Blot (non-reducing) of SLC / CCL21 antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CCL21 / SLC Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, WB
Unconjugated
50 µg/$356; 100 µg/$396
CCL21 / SLC Antibody - Western Blot (non-reducing) of SLC / CCL21 antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CCL21 / SLC Rabbit anti-Mouse Polyclonal (Biotin) Antibody
Mouse
ELISA, WB
Biotin Conjugated
25 µg/$356; 50 µg/$396
CCL21 / SLC Antibody - CCL21 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded mouse heart tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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CCL21 / SLC Rabbit anti-Human Polyclonal (aa23-52) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
CCL21 / SLC ELISA Kit
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Sandwich
96-Well Microplate
Mouse
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
CCL21 / SLC ELISA Kit
Select
Sandwich
96-Well Microplate
Rat
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
CCL21 / SLC ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
7.8 - 500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$715
CCL21 / SLC Antibody
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CCL21 / SLC Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$286; 100 µl/$321
CCL21 / SLC Antibody - Western blot of recombinant CCL21 / Exodus 2 / SLC.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CCL21 / SLC Rabbit anti-Mouse Polyclonal (aa5-130) (APC, Cy7) Antibody
Mouse
WB
APC, Cy7 Conjugated
100 µl/$497; 200 µl/$632; 500 µl/$1,132; 1 ml/$1,369; 2 ml/$1,916; 5 ml/$3,592
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CCL21 / SLC Rabbit anti-Rat Polyclonal Antibody
Rat
WB
Unconjugated
100 µg/$503
CCL21 / SLC ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$656
CCL21 / SLC Antibody - 1:100 staining mouse liver tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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CCL21 / SLC Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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CCL21 / SLC Rabbit anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
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CCL21 / SLC Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
CCL21 / SLC Antibody
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CCL21 / SLC Rabbit anti-Human Polyclonal (aa24-134) Antibody
Human
WB
Unconjugated
100 µl/$303; 500 µl/$476; 2 ml/$715; 5 ml/$1,182
CCL21 / SLC Antibody - Western Blot (non-reducing) of SLC / CCL21 antibody
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CCL21 / SLC Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$356; 100 µg/$396
CCL21 / SLC Antibody - Biotinylated Anti-Human Exodus-2 (CCL21) Western Blot Unreduced
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CCL21 / SLC Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
25 µg/$356; 50 µg/$396
CCL21 / SLC Antibody - Western blot of recombinant CCL21 / Exodus 2 / SLC.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CCL21 / SLC Rabbit anti-Rat Polyclonal (aa5-132) Antibody
Rat
WB
Unconjugated
100 µl/$312; 200 µl/$355; 500 µl/$500; 1 ml/$573; 2 ml/$780; 5 ml/$1,268
CCL21 / SLC ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CCL21 / SLC ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Select
CCL21 / SLC Rabbit anti-Human Polyclonal (aa23-52) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
Select
CCL21 / SLC Rabbit anti-Human Polyclonal (aa23-52) (Biotin) Antibody
Mouse, Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
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CCL21 / SLC Rabbit anti-Human Polyclonal (aa23-52) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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CCL21 / SLC Rabbit anti-Human Polyclonal (aa23-52) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
CCL21 / SLC Antibody - Immunohistochemical analysis of paraffin-embedded human-lymph, antibody was diluted at 1:200.
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CCL21 / SLC Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CCL21 / SLC Antibody - Immunohistochemistry of paraffin-embedded human liver tissue.
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CCL21 / SLC Rabbit anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
Viewing 1-25 of 113 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).