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Infectious Disease
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Location
Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
Telephone Numbers
Customer Service: (800) 227-6666 / (650) 697-3600
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Registration enables users to use special features of this website, such as past
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order histories, retained contact details for faster checkout, review submissions, and special promotions.
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CCL2 / MCP1
chemokine (C-C motif) ligand 2
CCL2 / MCP1 is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.
| Gene Name: | chemokine (C-C motif) ligand 2 |
| Family/Subfamily: | Intercrine , Intercrine beta |
| Synonyms: | CCL2, C-C motif chemokine 2, Chemokine (C-C motif) ligand 2, GDCF-2, HC11, HSMCR30, MCP1, SCYA2, Small-inducible cytokine A2, Monocyte secretory protein JE, MCAF, MCP-1, Monocyte chemotactic protein 1, SMC-CF |
| Target Sequences: | NM_002982 NP_002973.1 P13500 |
Publications (12)
1
Protective Role of Interleukin-17 in Murine NKT Cell-Driven Acute Experimental Hepatitis. Zenebech Wondimu, Tania Santodomingo-Garzon, Tai Le, and Mark G. Swain. The American journal of pathology. 2010 177:2334-46. (IHC-P; Mouse)
[Full Text Article]
[PubMed:20847291]
[PMC:PMC2966792]
2
Reduction of activated macrophages after ischaemia-reperfusion injury diminishes oxidative stress and ameliorates renal damage. Fet NG, Fiebeler A, Klinge U, Park JK, Barth S, Thepen T, Tolba RH. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2012 27:3149-55. (IHC; Rat)
[PubMed:22402584]
3
Infection with Mycobacterium avium subsp. paratuberculosis results in rapid interleukin-1 release and macrophage transepithelial migration. Lamont EA, O'Grady SM, Davis WC, Eckstein T, Sreevatsan S. Infection and immunity. 2012 80:3225-35. (Human)
[PubMed:22778093]
[PMC:PMC3418758]
☰ Filters
Products
Proteins
(48)
Type
Over-Expression Lysate
(2)
Recombinant
(44)
Target
CCL2 / MCP1
(48)
Application
SDS-PAGE
(2)
Product Group
Coronavirus Antibodies Proteins cDNAs
(48)
Cytokine Release Syndrome
(48)
Cytokine Release Syndrome Proteins
(48)
Format
Animal-free
(1)
Publications
No
(48)
Tag
6His, C-terminus
(2)
6His, N-terminus
(1)
GST
(1)
GST, N-terminus
(2)
His
(9)
His, N-Terminal
(1)
His,C-terminus
(2)
His-GST
(2)
His-T7
(2)
Human IgG1 Fc
(1)
Mouse IgG2 Fc
(1)
Myc-DDK (Flag)
(3)
Species
Bovine
(1)
Dog
(1)
Guinea pig
(1)
Horse
(1)
Human
(22)
Mouse
(13)
Pig
(2)
Rabbit
(2)
Rat
(2)
Rhesus monkey
(1)
Source
293T Cells
(1)
Baculovirus
(1)
CHO Cells
(2)
E. coli
(30)
HEK 293 Cells
(4)
Human Cells
(1)
Mammalian Cells
(1)
Wheat Germ Extract
(2)
Yeast
(4)
Purification
Purified
(19)
Low Endotoxin Level
Low endotoxin level
(22)
Biologically Active
Biologically active
(9)
Animal-free
Animal-free
(1)
E. coli
His
10.2 kDa
10 µg/$294; 50 µg/$522; 100 µg/$832; 200 µg/$1,034; 1 mg/$2,192; 500 µg/$1,712; 5 mg/$3,641; 2 mg/$2,383
CHO Cells
Human IgG1 Fc
Less than 0.06 EU/µg protein (determined by LAL method).
50 µg/$428; 10 µg/$323
E. coli
His
12.6 kD
1 mg/$1,679; 100 µg/$500; 20 µg/$364
HEK 293 Cells
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
8 kDa (SDS-PAGE)
5 µg/$262; 25 µg/$304; 1 mg/$1,740
E. coli
None
Less than 0.01 ng/µg (determined by LAL method).
The 76 amino acid recombinant protein has a predicted molecular mass of approximately 8,685 Da. The DTT-reduced protein migrates at approximately 8kDa and non-reduced protein migrates at approximately 13kDa by SDS-PAGE. The N-terminal amino acid is Glycin
10 µg/$306; 25 µg/$367; 100 µg/$744; 500 µg/$1,595
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~9 kDa
20 µg/$291; 100 µg/$490; 1 mg/$2,551
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
13.8 kDa
2 µg/$268; 10 µg/$349
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
8.6 kDa
5 µg/$268; 20 µg/$349
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
5 µg/$282; 20 µg/$370
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
14.0 kDa
2 µg/$268; 10 µg/$349
CHO Cells
Mouse IgG2 Fc
Less than 0.06 EU/µg protein (determined by LAL method).
50 µg/$428; 10 µg/$323
E. coli
None
Biologically active
8.7 kDa
5 µg/$282; 100 µg/$957; 500 µg/$1,747
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
HEK 293 Cells
Myc-DDK (Flag)
10.8 kDa
20 µg/$1,107
E. coli
His-T7
14.6 kDa
10 µg/$292; 50 µg/$512; 100 µg/$817; 200 µg/$1,018; 1 mg/$2,168; 500 µg/$1,690; 5 mg/$3,571; 2 mg/$2,359
E. coli
His
12.6 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
E. coli
His
15.4 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
E. coli
His
9.9 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
E. coli
His-GST
41.0 kDa
50 µg/$462; 10 µg/$284; 200 µg/$922; 100 µg/$737; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
E. coli
His
10.0 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
E. coli
His-T7
15.0 kDa
10 µg/$289; 50 µg/$490; 100 µg/$782; 200 µg/$977; 1 mg/$2,114; 500 µg/$1,640; 5 mg/$3,417; 2 mg/$2,304
E. coli
His-GST
41.2 kDa
10 µg/$289; 50 µg/$492; 100 µg/$785; 200 µg/$982; 1 mg/$2,119; 500 µg/$1,646; 5 mg/$3,431; 2 mg/$2,309
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