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CCKBR / Cckb

cholecystokinin B receptor

Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism.

Gene Name: cholecystokinin B receptor
Family/Subfamily: GPCR , Cholecystokinin
Synonyms: CCKBR, CCKB, Cholecystokinin-2 receptor, CCK-BR, CCK2 receptor, CCK2-R, CCKB-R, Cholecystokinin-B, GASR, CCK-B, CCK-B receptor, CCK2R, Cckb receptor, CCKRB, Cholecystokinin B receptor, Gastrin receptor
Target Sequences: NM_176875 NP_795344.1 P32239

Publications (4)

1
Control of somatostatin (SS) secretion by CCK-1 and CCK-2 receptors' occupation in RIN-14B cells, a rat pancreatic islet cell line. El-Kouhen K, Morisset J. Pancreas. 2010 39:127-34. (IF; Rat) [PubMed:19959964] Related Antibodies: LS-B2325.
2
Cholecystokinin and Somatostatin Negatively Affect Growth of the Somatostatin-RIN-14B Cells. El-Kouhen K, Morisset J. International journal of endocrinology. 2009 2009:875167. [PubMed:20011057] [PMC:PMC2778184] Related Antibodies: LS-B2325.
3
CCK1 and CCK2 receptors are expressed on pancreatic stellate cells and induce collagen production. Berna MJ, Seiz O, Nast JF, Benten D, Blker M, Koch J, Lohse AW, Pace A. The Journal of biological chemistry. 2010 285:38905-14. [PubMed:20843811] [PMC:PMC2998120] Related Antibodies: LS-B2325.
4
Chronic stimulation of corticotropin-releasing factor receptor 1 enhances the anxiogenic response of the cholecystokinin system. Sherrin T, Todorovic C, Zeyda T, Tan CH, Wong PT, Zhu YZ, Spiess J. Molecular psychiatry. 2009 March;14:291-307. [Full Text Article] [PubMed:18195718] Related Antibodies: LS-A1282.
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Antibodies (29)
ELISA Kits (13)
Proteins (2)
Custom (5)
Primary (29)
Recombinant (2)
Sandwich (8)
CCKBR / Cckb (44)
Human (32)
Mouse (11)
Rat (10)
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Guinea pig (4)
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IHC (7)
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IHC-P (5)
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ELISA (4)
ICC (1)
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IP (1)
Peptide-ELISA (3)
rabbit (28)
goat (1)
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IgG (15)
polyclonal pc (29)
96-Well Strip Plate (13)
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DY550 Conjugated (1)
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Unconjugated (21)
aa277-326 (4)
30-110 aa, N-terminal (1)
Cytoplasmic Domain (1)
Extracellular Domain (1)
Leu54 (1)
N-Terminus (1)
aa11-60 (1)
aa191-204 (1)
aa206-219 (1)
aa251-266 (1)
No (42)
Yes (2)
Plasma (2)
Serum (2)
Tissue Homogenates (1)
GST, N-terminus (2)
Human (2)
Wheat Germ Extract (2)
CCKBR / Cckb Antibody - Anti-CCKBR antibody IHC of human stomach. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Neuroscience
CCKBR / Cckb Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
CCKBR / Cckb Antibody - Anti-CCKBR antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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CCKBR / Cckb Goat anti-Human Polyclonal (aa251-266) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
CCKBR / Cckb Antibody - Anti-CCKBR antibody IHC of human stomach. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Neuroscience
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CCKBR / Cckb Rabbit anti-Human Polyclonal (Extracellular Domain) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
CCKBR / Cckb Antibody - Western blot analysis of lysates from A549, COS7, and K562 cells, using CCKBR Antibody. The lane on the right is blocked with the synthesized peptide.
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CCKBR / Cckb Rabbit anti-Human Polyclonal (aa11-60) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
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CCKBR / Cckb Rabbit anti-Human Polyclonal (aa206-219) Antibody
Rabbit, Dog, Horse, Bat, Human, Monkey
IHC, IHC-P, WB
Unconjugated
20 µl/$483; 100 µl/$832
CCKBR / Cckb Antibody - Western blot of CCK-BR antibody
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CCKBR / Cckb Rabbit anti-Human Polyclonal (30-110 aa, N-terminal) Antibody
Mouse, Rat, Human, Monkey
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CCKBR / Cckb Antibody - Western blot - Anti-CCKBR Picoband antibody
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CCKBR / Cckb Rabbit anti-Human Polyclonal Antibody
Human
Flo, ICC, IHC, IHC-Fr, WB
Unconjugated
10 µg/$318; 100 µg/$470
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CCKBR / Cckb Rabbit anti-Human Polyclonal (DY488) Antibody
Human
Flo
DY488 Conjugated
100 µg/$571
CCKBR / Cckb Antibody - 1:100 staining human liver carcinoma tissues by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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CCKBR / Cckb Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CCKBR / Cckb ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
CCKBR / Cckb Antibody - Immunohistochemistry image at a dilution of 1:400 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0) . Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 °C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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CCKBR / Cckb Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
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CCKBR / Cckb Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$331
CCKBR / Cckb Antibody - Western blot testing of human 1) PANC-1, 2) U-87 MG, 3) COLO-320 and 4) SGC-7901 cell lysate with CCKBR antibody at 0.5ug/ml. Predicted molecular weight ~48 kDa, but can be observed at 68-97 kDa.
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CCKBR / Cckb Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Flo, WB
Unconjugated
100 µg/$575
CCKBR / Cckb Antibody - Western blot analysis of extracts from COS-7 cells, A549 cells and K562 cells, using CCKBR antibody.
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CCKBR / Cckb Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
CCKBR / Cckb Antibody - Western blot analysis of CCKBR expression in HeLa (A) whole cell lysates.
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CCKBR / Cckb Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Rabbit, Bovine, Human, Monkey
IP, WB
Unconjugated
100 µl/$299
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CCKBR / Cckb Rabbit anti-Human Polyclonal (aa191-204) Antibody
Bat, Human
WB
Unconjugated
20 µl/$483; 100 µl/$832
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CCKBR / Cckb Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
CCKBR / Cckb Antibody - CCKBR antibody Western blot of Placenta lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CCKBR / Cckb Rabbit anti-Human Polyclonal (aa277-326) Antibody
Human
WB
Unconjugated
100 µl/$424
CCKBR / Cckb Antibody - CCKBR antibody Western blot of Placenta lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CCKBR / Cckb Rabbit anti-Human Polyclonal (aa277-326) (Biotin) Antibody
Guinea pig, Human, Orangutan
WB
Biotin Conjugated
100 µl/$469
CCKBR / Cckb Antibody - Western blot analysis of CCKBR expression in human brain (A); mouse brain (B); rat brain (C) whole cell lysates.
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CCKBR / Cckb Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$321
CCKBR / Cckb Antibody - Western blot of CCK-BR (L54) pAb in extracts from HeLa cells.
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CCKBR / Cckb Rabbit anti-Human Polyclonal (Leu54) Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µl/$321; 100 µl/$403
CCKBR / Cckb Antibody - Anti-CCKBR Antibody at 1:1000 dilution + H.brain tissue lysates Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution Predicted band size : 48,56 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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CCKBR / Cckb Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µl/$386
CCKBR / Cckb Antibody - Western blot analysis of extracts of various cell lines, using CCKBR antibody at 1:3000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 90s.
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CCKBR / Cckb Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
CCKBR / Cckb Antibody - Western blot analysis of extracts of human stomach cancer tissue using CCKBR Polyclonal Antibody.
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CCKBR / Cckb Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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CCKBR / Cckb Rabbit anti-Human Polyclonal (DY550) Antibody
Human
Flo
DY550 Conjugated
100 µg/$571
Viewing 1-25 of 44 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).