c-Kit / CD117

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.

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Products

Antibodies (475)

ELISA Kits (31)

Proteins (20)

Type

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Custom (4)

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Primary (475)

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Target

c-Kit / CD117 (526)

Reactivity

Human (403)

Mouse (139)

Rat (22)

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aa546-976 (12)

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Internal (5)

aa100-300 (4)

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660-740 aa (2)

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Glu930 (1)

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Low Endotoxin Level

Low endotoxin level (9)

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PathPlus™ c-Kit / CD117 Antibody (Extracellular Domain) LS-A9389

Cancer Pathology

Cancer

Fast Shipping

(5.0) Rating

(1) Publication(s)

Antibody:

c-Kit / CD117 Rabbit anti-Human Polyclonal (Extracellular Domain) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$460

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IHC-plus™ c-Kit / CD117 Antibody (clone X1) LS-B6060

(4.0) Rating

Antibody:

c-Kit / CD117 Mouse anti-Human Monoclonal (X1) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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c-Kit / CD117 Antibody (660-740 aa) LS-C382844

(4.0) Rating

(1) Publication(s)

Antibody:

c-Kit / CD117 Rabbit anti-Human Polyclonal (660-740 aa) Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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PathPlus™ c-Kit / CD117 Antibody (clone 9A11) LS-B10212

Cancer Pathology

Cancer

(5.0) Rating

Antibody:

c-Kit / CD117 Mouse anti-Human Monoclonal (9A11) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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c-Kit / CD117 Antibody (clone ACK4) LS-C34582

Antibody:

c-Kit / CD117 Rat anti-Mouse Monoclonal (ACK4) Antibody

Reactivity:

Mouse

Applications:

Flo, IHC, IHC-Fr

Format:

Unconjugated

Price:

250 µg/$381

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c-Kit / CD117 Antibody (clone OTI2C1D5) LS-C175534

Antibody:

c-Kit / CD117 Mouse anti-Human Monoclonal (OTI2C1D5) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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PathPlus™ c-Kit / CD117 Antibody (aa685-697) LS-B16619

Cancer Pathology

Cancer

(5.0) Rating

Antibody:

c-Kit / CD117 Goat anti-Human Polyclonal (aa685-697) Antibody

Reactivity:

Dog, Bovine, Pig, Human

Applications:

Flo, IF, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µg/$485

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Mouse/Human Phospho-c-Kit / CD117 (Tyr703) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1182

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Mouse/Human/Rat Phospho-c-Kit / CD117 (Tyr721) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1552

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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IHC-plus™ c-Kit / CD117 Antibody (clone 5F6) LS-B6058

(4.0) Rating

Antibody:

c-Kit / CD117 Mouse anti-Human Monoclonal (5F6) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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c-Kit / CD117 Antibody (aa912-941, PE) LS-C282542

Antibody:

c-Kit / CD117 Rabbit anti-Human Polyclonal (aa912-941) (PE) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, Flo, IF, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$697

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c-Kit / CD117 Antibody (clone 2B8/BM) LS-C187513

Antibody:

c-Kit / CD117 Mouse anti-Pig Monoclonal (2B8/BM) Antibody

Reactivity:

Pig

Applications:

Flo, IHC, IHC-Fr, IP, WB

Format:

Unconjugated

Price:

0.1 mg/$457

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IHC-plus™ c-Kit / CD117 Antibody (clone 6G12) LS-B6057

(4.0) Rating

Antibody:

c-Kit / CD117 Mouse anti-Human Monoclonal (6G12) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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c-Kit / CD117 Antibody (clone YR145, Concentrated) LS-C202814

Antibody:

c-Kit / CD117 Rabbit anti-Human Monoclonal (Concentrated) (YR145) Antibody

Reactivity:

Human

Applications:

IHC, IHC-Fr, IHC-P

Format:

Unconjugated, Concentrated

Price:

1 ml/$1,157

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c-Kit / CD117 Antibody (Ser715) LS-C177669

Antibody:

c-Kit / CD117 Rabbit anti-Human Polyclonal (Ser715) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

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c-Kit / CD117 Antibody LS-C808629

Antibody:

c-Kit / CD117 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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Human c-Kit / CD117 (Sandwich ELISA) ELISA Kit - LS-F11883

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

3.12 - 200 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$585

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Rat c-Kit / CD117 (Sandwich ELISA) ELISA Kit - LS-F49274

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.78 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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c-Kit / CD117 Antibody LS-C157852

Antibody:

c-Kit / CD117 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

IF, WB

Format:

Unconjugated

Price:

400 µl/$393

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c-Kit / CD117 Antibody (phospho-Ser959, PE) LS-C261310

Antibody:

c-Kit / CD117 Rabbit anti-Human Polyclonal (pSer959) (PE) Antibody

Reactivity:

Human

Applications:

DB, ELISA

Format:

PE Conjugated

Price:

200 µl/$952

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c-Kit / CD117 Antibody (clone 2B8, Azide-free, Low Endotoxin) LS-C810635

Antibody:

c-Kit / CD117 Rat anti-Mouse Monoclonal (Azide-free, Low Endotoxin) (2B8) Antibody

Reactivity:

Mouse

Applications:

Flo, IF, IHC, IP

Format:

Unconjugated, Azide-free, Low Endotoxin

Price:

50 µg/$248; 500 µg/$333; 1 mg/$433

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c-Kit / CD117 Antibody (APC) LS-C485438

Antibody:

c-Kit / CD117 Rabbit anti-Human Polyclonal (APC) Antibody

Reactivity:

Human

Applications:

Flo

Format:

APC Conjugated

Price:

25 Tests/$278; 100 Tests/$421

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c-Kit / CD117 Antibody (clone 018, Preservative Free) LS-C819056

Antibody:

c-Kit / CD117 Rabbit anti-Human Monoclonal (Preservative Free) (018) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated, Preservative Free

Price:

20 µl/$271; 100 µl/$412

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c-Kit / CD117 Antibody (aa9-40) LS-C97561

Antibody:

c-Kit / CD117 Rabbit anti-Human Polyclonal (aa9-40) Antibody

Reactivity:

Human, Primate

Applications:

Flo, IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

c-Kit / CD117 Antibody LS-C812547

Antibody:

c-Kit / CD117 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$332; 100 µg/$404; 200 µg/$505

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