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BUB1B / BubR1
BUB1 mitotic checkpoint serine/threonine kinase B
Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression.
| Gene Name: | BUB1 mitotic checkpoint serine/threonine kinase B |
| Family/Subfamily: | Protein Kinase , BUB1 |
| Synonyms: | BUB1B, Bub1A, BUBR1, HBUBR1, Protein SSK1, SSK1, BUB1beta, MAD3L |
| Target Sequences: | NM_001211 NP_001202.4 O60566 |
Publications (7)
1
Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC. Chan GK, Jablonski SA, Sudakin V, Hittle JC, Yen TJ. The Journal of cell biology. 1999 146:941-54.
[PubMed:10477750]
[PMC:PMC2169490]
2
Dido disruption leads to centrosome amplification and mitotic checkpoint defects compromising chromosome stability. Trachana V, van Wely KH, Guerrero AA, Ftterer A, Martnez-A C. Proceedings of the National Academy of Sciences of the United States of America. 2007 104:2691-6.
[PubMed:17299043]
[PMC:PMC1815243]
3
Plk1 is upregulated in androgen-insensitive prostate cancer cells and its inhibition leads to necroptosis. Sili V, Redondo-Muoz J, Carrera AC. Oncogene. 2012 (WB; Human)
[PubMed:22890325]
[PMC:PMC3499666]
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Antibodies
(67)
Type
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(67)
Target
BUB1B / BubR1
(67)
Reactivity
Human
(64)
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(20)
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(6)
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(2)
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(9)
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(40)
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(14)
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(61)
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(6)
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(18)
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(2)
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(34)
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(6)
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(1)
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(1)
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rabbit
(29)
mouse
(35)
sheep
(3)
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(3)
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(22)
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(3)
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(22)
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(6)
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(2)
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monoclonal mc
(36)
polyclonal pc
(31)
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(2)
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(1)
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(55)
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(7)
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(2)
310-390 aa, Internal
(1)
Thr368
(1)
aa230-394
(1)
aa341-390
(1)
aa350-400
(1)
Publications
No
(66)
Yes
(1)
![BUB1B / BubR1 Antibody - Immunofluorescence of an asynchronous cycling population of human cells (U2OS) with BUBR1 [8G1] antibody. No signal is detected from interphase cells, whereas cells undergoing mitosis accumulate BubR1 at the kinetochores. Image reveals kinetochores at prometaphase. This image was taken for the unconjugated form of this product. Other forms have not been tested.](https://lsbio-7d62.kxcdn.com/image2/bub1b-bubr1-antibody-aa1-350-clone-8g1-ls-c2771/3447_423119.jpg)
BUB1B / BubR1 Mouse anti-Human Monoclonal (aa1-350) (8G1) Antibody
Mouse, Human
IF, WB
Unconjugated
0.1 ml/$386
BUB1B / BubR1 Mouse anti-Human Monoclonal (2G5) Antibody
Human
ELISA, IHC, IHC-P, PLA, RNAi, WB
Unconjugated
50 µg/$460
BUB1B / BubR1 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
BUB1B / BubR1 Mouse anti-Human Monoclonal (OTI6E5) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
BUB1B / BubR1 Mouse anti-Human Monoclonal (OTI6E3) Antibody
Dog, Rat, Human, Monkey
Flo, IF, WB
Unconjugated
100 µl/$434
BUB1B / BubR1 Mouse anti-Human Monoclonal (3F2) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
BUB1B / BubR1 Mouse anti-Human Monoclonal (OTI3D9) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
BUB1B / BubR1 Mouse anti-Human Monoclonal (Carrier-free) (OTI3D9) Antibody
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
BUB1B / BubR1 Mouse anti-Human Monoclonal (Carrier-free) (OTI6E5) Antibody
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
BUB1B / BubR1 Mouse anti-Human Monoclonal (OTI15E11) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
BUB1B / BubR1 Mouse anti-Human Monoclonal (Carrier-free) (OTI15E11) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
BUB1B / BubR1 Mouse anti-Human Monoclonal (OTI10E7) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
BUB1B / BubR1 Mouse anti-Human Monoclonal (Carrier-free) (OTI10E7) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
BUB1B / BubR1 Mouse anti-Human Monoclonal (OTI10B7) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
BUB1B / BubR1 Mouse anti-Human Monoclonal (Carrier-free) (OTI10B7) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
BUB1B / BubR1 Mouse anti-Human Monoclonal (OTI11G2) Antibody
Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
BUB1B / BubR1 Mouse anti-Human Monoclonal (Carrier-free) (OTI11G2) Antibody
Human, Monkey
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
BUB1B / BubR1 Mouse anti-Human Monoclonal (OTI11D7) Antibody
Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
BUB1B / BubR1 Mouse anti-Human Monoclonal (Carrier-free) (OTI11D7) Antibody
Human, Monkey
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
BUB1B / BubR1 Mouse anti-Human Monoclonal (OTI5D9) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
BUB1B / BubR1 Mouse anti-Human Monoclonal (Carrier-free) (OTI5D9) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
BUB1B / BubR1 Mouse anti-Human Monoclonal (OTI3C7) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
BUB1B / BubR1 Mouse anti-Human Monoclonal (Carrier-free) (OTI3C7) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
BUB1B / BubR1 Rabbit anti-Human Monoclonal (11C1018) Antibody
Human
WB
Unconjugated
100 µl/$688
BUB1B / BubR1 Rabbit anti-Human Polyclonal (aa230-394) Antibody
Human
ELISA, IF, IHC, IHC-P, IP
Unconjugated
50 µg/$294; 100 µg/$360
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