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BMP4
bone morphogenetic protein 4
BMP4 is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein.
| Gene Name: | bone morphogenetic protein 4 |
| Family/Subfamily: | TGF beta , not assigned-TGF beta |
| Synonyms: | BMP4, BMP-2B, BMP-4, BMP2B, BMP2B1, Bone morphogenetic protein 2B, Bone morphogenetic protein 4, DVR4, MCOPS6, OFC11, Zyme |
| Target Sequences: | NM_001202 NP_001193.2 P12644 |
Publications (3)
1
Production of BMP4 by endothelial cells is crucial for endogenous thymic regeneration. Wertheimer T, Velardi E, Tsai J, Cooper K, Xiao S, Kloss CC, Ottmüller KJ, Mokhtari Z, Brede C, deRoos P, Kinsella S, Palikuqi B, Ginsberg M, Young LF, Kreines F, Lieberman SR, Lazrak A, Guo P, Malard F, Smith OM, Shono Y, Jenq RR, Hanash AM, Nolan DJ, Butler JM, Beilhack A, Manley NR, Rafii S, Dudakov JA, van den Brink MRM. Science immunology. 2018 January;3:pii: eaal2736. [Full Text Article]
[PubMed:29330161]
[PMC:PMC5795617]
2
Stimulation of Epithelial Sodium Channels in Endothelial Cells by Bone Morphogenetic Protein-4 Contributes to Salt-Sensitive Hypertension in Rats. Xu Yang, Na Niu, Chen Liang, Ming-Ming Wu, Liang-Liang Tang, Qiu-Shi Wang, Jie Lou, Bin-Lin Song, Wei-Wan Zheng, He-Ping Ma, Zhi-Ren Zhang. Oxidative medicine and cellular longevity. 2020 November;2020:3921897. [Full Text Article]
[PubMed:33194000]
[PMC:PMC7641672]
3
Potential Role of Circulating Endoglin in Hypertension via the Upregulated Expression of BMP4. Eunate Gallardo-Vara, Luis Gamella-Pozuelo, Lucía Perez-Roque, José L Bartha, Irene Garcia-Palmero, J Ignacio Casal, José M López-Novoa, Miguel Pericacho, Carmelo Bernabeu. Cells. 2020 Apr;9:988. [Full Text Article]
[PubMed:32316263]
[PMC:PMC7226995]
☰ Filters
Products
Proteins
(28)
Type
Over-Expression Lysate
(7)
Recombinant
(21)
Target
BMP4
(28)
Format
Animal-free
(1)
Publications
No
(28)
Tag
His
(8)
His, N-Terminal
(1)
His-GST
(1)
His-SUMO
(1)
His-T7
(1)
Myc-DDK (Flag)
(7)
Species
Bovine
(1)
Chicken
(1)
Human
(15)
Mouse
(2)
Pig
(2)
Rabbit
(2)
Rat
(2)
Source
293T Cells
(4)
E. coli
(21)
HEK 293 Cells
(3)
Purification
Purified
(8)
Low Endotoxin Level
Low endotoxin level
(9)
Biologically Active
Biologically active
(7)
Animal-free
Animal-free
(1)
E. coli
His
17.8 kDa
10 µg/$297; 50 µg/$542; 100 µg/$865; 200 µg/$1,065; 1 mg/$2,239; 500 µg/$1,755; 5 mg/$3,781; 2 mg/$2,430
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
2 µg/$268; 10 µg/$349
E. coli
His
22.2 kDa
10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257
E. coli
His-T7
48.2 kDa
10 µg/$282; 50 µg/$450; 100 µg/$717; 200 µg/$897; 1 mg/$2,010; 500 µg/$1,547; 5 mg/$3,137; 2 mg/$2,198
E. coli
His
14.4 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
2 µg/$268; 10 µg/$349
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
2 µg/$281; 10 µg/$369
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
1 µg/$268; 5 µg/$349
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
100 µg/$317; 500 µg/$526; 20 µg/$245
E. coli
His
21.4 kDa
10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298
E. coli
His-GST
52.0 kDa
10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257
E. coli
His
19.5 kDa
10 µg/$289; 50 µg/$492; 100 µg/$785; 200 µg/$982; 1 mg/$2,119; 500 µg/$1,646; 5 mg/$3,431; 2 mg/$2,309
E. coli
His
22.0 kDa
10 µg/$297; 50 µg/$542; 100 µg/$865; 200 µg/$1,065; 1 mg/$2,239; 500 µg/$1,755; 5 mg/$3,781; 2 mg/$2,430
E. coli
His
22.6 kDa
10 µg/$289; 50 µg/$492; 100 µg/$785; 200 µg/$982; 1 mg/$2,119; 500 µg/$1,646; 5 mg/$3,431; 2 mg/$2,309
E. coli
His
22.5 kDa
10 µg/$297; 50 µg/$542; 100 µg/$865; 200 µg/$1,065; 1 mg/$2,239; 500 µg/$1,755; 5 mg/$3,781; 2 mg/$2,430
HEK 293 Cells
Myc-DDK (Flag)
46.4 kDa
100 µg/$494
293T Cells
Myc-DDK (Flag)
46.4 kDa
20 µg/$150
293T Cells
Myc-DDK (Flag)
46.4 kDa
20 µg/$150
293T Cells
Myc-DDK (Flag)
46.4 kDa
20 µg/$150
293T Cells
Myc-DDK (Flag)
46.4 kDa
20 µg/$150
HEK 293 Cells
Myc-DDK (Flag)
46.4 kDa
100 µg/$494
E. coli
None
Less than 0.2 EU/µg protein (determined by LAL method).
13.3 kDa
10 µg/$364; 1 mg/$3,412
HEK 293 Cells
Myc-DDK (Flag)
46.4 kDa
100 µg/$494
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein.
The 106 amino acid recombinant protein has a predicted molecular mass of approximately 12 kD. Recombinant BMP-4 is a disulphide bond linked homodimer. The predicted N-terminal amino acid is Lys.
2 µg/$272; 10 µg/$352
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein.
The 106 amino acid recombinant protein has a predicted molecular mass of approximately 12 kD. The DTT-non reduced protein migrates at approximately 31-36 kD on SDS-PAGE. The predicted N-terminal amino acid is Lys.
2 µg/$272; 10 µg/$352
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