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BMP4
bone morphogenetic protein 4
BMP4 is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein.
| Gene Name: | bone morphogenetic protein 4 |
| Family/Subfamily: | TGF beta , not assigned-TGF beta |
| Synonyms: | BMP4, BMP-2B, BMP-4, BMP2B, BMP2B1, Bone morphogenetic protein 2B, Bone morphogenetic protein 4, DVR4, MCOPS6, OFC11, Zyme |
| Target Sequences: | NM_001202 NP_001193.2 P12644 |
Publications (3)
1
Production of BMP4 by endothelial cells is crucial for endogenous thymic regeneration. Wertheimer T, Velardi E, Tsai J, Cooper K, Xiao S, Kloss CC, Ottmüller KJ, Mokhtari Z, Brede C, deRoos P, Kinsella S, Palikuqi B, Ginsberg M, Young LF, Kreines F, Lieberman SR, Lazrak A, Guo P, Malard F, Smith OM, Shono Y, Jenq RR, Hanash AM, Nolan DJ, Butler JM, Beilhack A, Manley NR, Rafii S, Dudakov JA, van den Brink MRM. Science immunology. 2018 January;3:pii: eaal2736. [Full Text Article]
[PubMed:29330161]
[PMC:PMC5795617]
2
Stimulation of Epithelial Sodium Channels in Endothelial Cells by Bone Morphogenetic Protein-4 Contributes to Salt-Sensitive Hypertension in Rats. Xu Yang, Na Niu, Chen Liang, Ming-Ming Wu, Liang-Liang Tang, Qiu-Shi Wang, Jie Lou, Bin-Lin Song, Wei-Wan Zheng, He-Ping Ma, Zhi-Ren Zhang. Oxidative medicine and cellular longevity. 2020 November;2020:3921897. [Full Text Article]
[PubMed:33194000]
[PMC:PMC7641672]
3
Potential Role of Circulating Endoglin in Hypertension via the Upregulated Expression of BMP4. Eunate Gallardo-Vara, Luis Gamella-Pozuelo, Lucía Perez-Roque, José L Bartha, Irene Garcia-Palmero, J Ignacio Casal, José M López-Novoa, Miguel Pericacho, Carmelo Bernabeu. Cells. 2020 Apr;9:988. [Full Text Article]
[PubMed:32316263]
[PMC:PMC7226995]
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(124)
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BMP4
(124)
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Publications
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(124)
BMP4 Mouse anti-Mouse Monoclonal (3H2.3) Antibody
Mouse, Rat, Human
ELISA, ICC, WB
Unconjugated
100 µg/$826
BMP4 Mouse anti-Mouse Monoclonal (HRP) Antibody
Mouse, Rat, Human
ELISA, ICC, WB
HRP Conjugated
100 µl/$1,049
BMP4 Mouse anti-Mouse Monoclonal (Biotin) Antibody
Mouse, Rat, Human
ELISA, ICC, WB
Biotin Conjugated
100 µl/$1,049
BMP4 Mouse anti-Mouse Monoclonal (FITC) Antibody
Mouse, Rat, Human
ELISA, ICC, WB
FITC Conjugated
100 µl/$1,049
BMP4 Mouse anti-Mouse Monoclonal (APC) Antibody
Mouse, Rat, Human
ELISA, ICC, WB
APC Conjugated
100 µl/$1,049
BMP4 Mouse anti-Mouse Monoclonal (PE) Antibody
Mouse, Rat, Human
ELISA, ICC, WB
PE Conjugated
100 µl/$1,049
BMP4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
BMP4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
BMP4 Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
500 µg/$326
BMP4 Mouse anti-Human Monoclonal (aa293-408) (Carrier-free) (UMAB42) Antibody
Human
IF, IHC, PMA, WB
Unconjugated, Carrier-free
100 µg/$539
BMP4 Mouse anti-Human Monoclonal Antibody
Human
Flo, ICC, IF
Unconjugated
100 µl/$412
BMP4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC-P, WB
Unconjugated
60 µl/$460
BMP4 Mouse anti-Human Monoclonal (aa293-408) (UMAB42) Antibody
Human
IF, IHC, PMA, WB
Unconjugated
100 µl/$493
BMP4 Rabbit anti-Cow Polyclonal (aa219-392) Antibody
Mouse, Bovine, Rat, Cow, Human
WB
Unconjugated
100 µl/$317; 200 µl/$362; 500 µl/$513; 1 ml/$589; 2 ml/$812; 5 ml/$1,324
Fast Shipping
BMP4 Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
Fast Shipping
BMP4 Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
BMP4 Mouse anti-Human Monoclonal (3C11H8) Antibody
Human
ELISA, IF, WB
Unconjugated
100 µl/$459
BMP4 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
BMP4 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
BMP4 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
BMP4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC
Unconjugated
20 µl/$275; 100 µl/$389
BMP4 Mouse anti-Human Monoclonal (3C11C7) Antibody
Human
ELISA, Flo
Unconjugated
100 µl/$459
BMP4 Mouse anti-Human Monoclonal (OTI6B7) Antibody
Human
IF, WB
Unconjugated
100 µl/$434
BMP4 Mouse anti-Human Monoclonal (aa293-408) (Carrier-free) (OTI6B7) Antibody
Human
IF, WB
Unconjugated, Carrier-free
100 µg/$511
BMP4 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$286; 100 µl/$321
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of 124
product results
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